Download MendeleyCrystal Structure of Isoform 2 of Purine Nucleoside Phosphorylase
Torini, J.R., Romanello, L., Faheem, M., Bird, L., Owens, R., Brandao-Neto, J., Pereira, H.M.To be published.
5TBV
Crystal Structure of Isoform 2 of Purine Nucleoside Phosphorylase complexed with tubercidin
- PDB DOI: https://doi.org/10.2210/pdb5TBV/pdb
- Classification: TRANSFERASE
- Organism(s): Schistosoma mansoni
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2016-09-13 Released: 2017-10-11
- Funding Organization(s): Sao Paulo Research Foundation (FAPESP), Brazilian National Council for Scientific and Technological Development (CNPq)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.95 Å
- R-Value Free: 0.202
- R-Value Work: 0.179
- R-Value Observed: 0.180
Starting Model: experimental
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This is version 1.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Purine nucleoside phosphorylase | 287 | Schistosoma mansoni | Mutation(s): 0 EC: 2.4.2.1 |  | |
UniProt | |||||
Find proteins for A0A0U3AGT1 (Schistosoma mansoni) Explore A0A0U3AGT1 Go to UniProtKB: A0A0U3AGT1 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | A0A0U3AGT1 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| TBN Query on TBN | B [auth A] | '2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL C11 H14 N4 O4 HDZZVAMISRMYHH-KCGFPETGSA-N |  | ||
| SO4 Query on SO4 | C [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
| DMS Query on DMS | D [auth A] | DIMETHYL SULFOXIDE C2 H6 O S IAZDPXIOMUYVGZ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.95 Å
- R-Value Free: 0.202
- R-Value Work: 0.179
- R-Value Observed: 0.180
- Space Group: P 21 3
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 91.981 | α = 90 |
| b = 91.981 | β = 90 |
| c = 91.981 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| xia2 | data scaling |
| xia2 | data reduction |
| PHASER | phasing |
| PDB_EXTRACT | data extraction |
Entry History & Funding Information
Deposition Data
- Released Date: 2017-10-11 Deposition Author(s): Faheem, M., Torini, J.R., Romanello, L., Brandao-Neto, J., Pereira, H.M.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Sao Paulo Research Foundation (FAPESP) | Brazil | 2012/14223-9 |
| Brazilian National Council for Scientific and Technological Development (CNPq) | Brazil | 474402/2013-4 |
Revision History (Full details and data files)
- Version 1.0: 2017-10-11
Type: Initial release - Version 1.1: 2019-04-17
Changes: Author supporting evidence, Data collection - Version 1.2: 2020-01-01
Changes: Author supporting evidence - Version 1.3: 2023-10-04
Changes: Data collection, Database references, Refinement description
