Crystal Structure of the Human CAMKK2B in complex with CP673451
Counago, R.M., dos Reis, C.V., de Souza, G.P., Ramos, P.Z., Drewry, D., Massirer, K.B., Arruda, P., Edwards, A.M., Elkins, J.M.To be published.
Experimental Data Snapshot
Starting Model: experimental
View more details
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Calcium/calmodulin-dependent protein kinase kinase 2 | 291 | Homo sapiens | Mutation(s): 0  Gene Names: CAMKK2, CAMKKB, KIAA0787 EC: 2.7.11.17 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q96RR4 (Homo sapiens) Explore Q96RR4  Go to UniProtKB:  Q96RR4 | |||||
PHAROS:  Q96RR4 GTEx:  ENSG00000110931  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q96RR4 | ||||
Sequence AnnotationsExpand | |||||
|
Ligands 2 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
34U Query on 34U | B [auth A] | 1-{2-[5-(2-methoxyethoxy)-1H-benzimidazol-1-yl]quinolin-8-yl}piperidin-4-amine C24 H27 N5 O2 DEEOXSOLTLIWMG-UHFFFAOYSA-N | |||
GOL Query on GOL | C [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 48.998 | α = 90 |
b = 77.681 | β = 90 |
c = 78.064 | γ = 90 |
Software Name | Purpose |
---|---|
REFMAC | refinement |
XDS | data reduction |
Aimless | data scaling |
PHASER | phasing |
Funding Organization | Location | Grant Number |
---|---|---|
Sao Paulo Research Foundation (FAPESP) | Brazil | 13/50724-5 |