Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant Y142A
Reis, R.A.G., Pinheiro, M.P., Nonato, M.C.To be published.
Experimental Data Snapshot
Starting Model: experimental
View more details
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Dihydroorotate dehydrogenase (fumarate) | 354 | Leishmania major | Mutation(s): 1  Gene Names: DHODH, LMJF_16_0530 EC: 1.3.98.1 | ||
UniProt | |||||
Find proteins for Q4QEW7 (Leishmania major) Explore Q4QEW7  Go to UniProtKB:  Q4QEW7 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q4QEW7 | ||||
Sequence AnnotationsExpand | |||||
|
Ligands 3 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
FMN Query on FMN | C [auth A], F [auth B] | FLAVIN MONONUCLEOTIDE C17 H21 N4 O9 P FVTCRASFADXXNN-SCRDCRAPSA-N | |||
SO4 Query on SO4 | E [auth A], H [auth B] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L | |||
GOL Query on GOL | D [auth A], G [auth B] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |
Modified Residues 1 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Type | Formula | 2D Diagram | Parent |
CSX Query on CSX | A, B | L-PEPTIDE LINKING | C3 H7 N O3 S | CYS |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 140.651 | α = 90 |
b = 140.651 | β = 90 |
c = 68.001 | γ = 120 |
Software Name | Purpose |
---|---|
REFMAC | refinement |
MOSFLM | data reduction |
SCALA | data scaling |
MOLREP | phasing |
PDB_EXTRACT | data extraction |
Funding Organization | Location | Grant Number |
---|---|---|
Sao Paulo Research Foundation (FAPESP) | Brazil | 11/23504-9 |
Sao Paulo Research Foundation (FAPESP) | Brazil | 07/08703-0 |