Download MendeleyCrystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
Ferrie, R.P., Chen, Y., Antoshchenko, T., Cooney, O.M., Huang, Y., Park, H.W.To be published.
6DO2
Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
- PDB DOI: https://doi.org/10.2210/pdb6DO2/pdb
- Classification: chaperone, hydrolase
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2018-06-08 Released: 2019-06-12
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.70 Å
- R-Value Free: 0.232
- R-Value Work: 0.207
- R-Value Observed: 0.208
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Endoplasmic reticulum chaperone BiP | 382 | Homo sapiens | Mutation(s): 0 Gene Names: HSPA5, GRP78 EC: 3.6.4.10 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P11021 (Homo sapiens) Explore P11021 Go to UniProtKB: P11021 | |||||
PHAROS: P11021 GTEx: ENSG00000044574 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P11021 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| H5V (Subject of Investigation/LOI) Query on H5V | C [auth A], D [auth B] | 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine C12 H16 N4 O4 IRZRJANZDIOOIF-GAJNKVMBSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.70 Å
- R-Value Free: 0.232
- R-Value Work: 0.207
- R-Value Observed: 0.208
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 55.41 | α = 90 |
| b = 75.02 | β = 99.11 |
| c = 89.48 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PDB_EXTRACT | data extraction |
| BUSTER | refinement |
| XDS | data reduction |
| BUSTER | phasing |
Entry History
Deposition Data
- Released Date: 2019-06-12 Deposition Author(s): Ferrie, R.P., Chen, Y., Antoshchenko, T., Cooney, O.M., Huang, Y., Park, H.W.
Revision History (Full details and data files)
- Version 1.0: 2019-06-12
Type: Initial release - Version 1.1: 2024-03-13
Changes: Data collection, Database references
