Download MendeleyStructural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
Battles, M.B., McLellan, J.S.To be published.
6EAD
CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT F140I STABILIZED IN THE PREFUSION STATE
- PDB DOI: https://doi.org/10.2210/pdb6EAD/pdb
- Classification: VIRAL PROTEIN
- Organism(s): human respiratory syncytial virus
- Expression System: Homo sapiens
- Mutation(s): Yes
- Deposited: 2018-08-03 Released: 2019-08-07
- Funding Organization(s): National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID), National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.80 Å
- R-Value Free: 0.230
- R-Value Work: 0.201
- R-Value Observed: 0.203
Starting Model: experimental
View more details
This is version 1.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Fusion glycoprotein F0 | A [auth F] | 573 | human respiratory syncytial virus | Mutation(s): 3 |  |
UniProt | |||||
Find proteins for P03420 (Human respiratory syncytial virus A (strain A2)) Explore P03420 Go to UniProtKB: P03420 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P03420 | ||||
Glycosylation | |||||
| Glycosylation Sites: 2 | |||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAG Query on NAG | B [auth F], C [auth F] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
| NHE Query on NHE | F | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID C8 H17 N O3 S MKWKNSIESPFAQN-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | D [auth F], E [auth F] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.80 Å
- R-Value Free: 0.230
- R-Value Work: 0.201
- R-Value Observed: 0.203
- Space Group: P 41 3 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 168.95 | α = 90 |
| b = 168.95 | β = 90 |
| c = 168.95 | γ = 90 |
| Software Name | Purpose |
|---|---|
| Aimless | data scaling |
| PHENIX | refinement |
| PDB_EXTRACT | data extraction |
| MOSFLM | data reduction |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2019-08-07 Deposition Author(s): Battles, M.B., McLellan, J.S.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | United States | 5T32AI007519-18 |
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | P20GM113132 |
Revision History (Full details and data files)
- Version 1.0: 2019-08-07
Type: Initial release - Version 1.1: 2019-12-18
Changes: Author supporting evidence - Version 1.2: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Data collection, Derived calculations, Structure summary - Version 1.3: 2023-10-11
Changes: Data collection, Database references, Refinement description, Structure summary
