Unc-51-Like Kinase 3 (ULK3) In Complex With Bosutinib
Mathea, S., Salah, E., Moroglu, M., Scorah, A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Huber, K., Knapp, S.To be published.
Experimental Data Snapshot
Starting Model: experimental
View more details
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Serine/threonine-protein kinase ULK3 | A [auth U] | 276 | Homo sapiens | Mutation(s): 0  Gene Names: ULK3 EC: 2.7.11.1 | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q6PHR2 (Homo sapiens) Explore Q6PHR2  Go to UniProtKB:  Q6PHR2 | |||||
PHAROS:  Q6PHR2 GTEx:  ENSG00000140474  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q6PHR2 | ||||
Sequence AnnotationsExpand | |||||
|
Ligands 1 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
DB8 Query on DB8 | B [auth U], C [auth U] | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile C26 H29 Cl2 N5 O3 UBPYILGKFZZVDX-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 92.375 | α = 90 |
b = 169.406 | β = 90 |
c = 45.919 | γ = 90 |
Software Name | Purpose |
---|---|
REFMAC | refinement |
xia2 | data reduction |
xia2 | data scaling |
PHASER | phasing |