Download MendeleyCFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALBF
Gill, N.P.To be published.
7JZP
CFTR Associated Ligand (CAL) PDZ domain bound to peptidomimetic LyCALBF
- PDB DOI: https://doi.org/10.2210/pdb7JZP/pdb
- Classification: PEPTIDE BINDING PROTEIN
- Organism(s): Homo sapiens, synthetic construct
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2020-09-02 Released: 2022-02-02
- Funding Organization(s): National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK), National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.95 Å
- R-Value Free: 0.217
- R-Value Work: 0.178
- R-Value Observed: 0.182
Starting Model: experimental
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This is version 1.2 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Golgi-associated PDZ and coiled-coil motif-containing protein | 87 | Homo sapiens | Mutation(s): 0 Gene Names: GOPC, CAL, FIG |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9HD26 (Homo sapiens) Explore Q9HD26 Go to UniProtKB: Q9HD26 | |||||
PHAROS: Q9HD26 GTEx: ENSG00000047932 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9HD26 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| LyCALBF peptide core | 10 | synthetic construct | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| BZ2 (Subject of Investigation/LOI) Query on BZ2 | E [auth C], F [auth D] | 1-benzofuran-2-carboxylic acid C9 H6 O3 OFFSPAZVIVZPHU-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.95 Å
- R-Value Free: 0.217
- R-Value Work: 0.178
- R-Value Observed: 0.182
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 36.307 | α = 90 |
| b = 47.978 | β = 90 |
| c = 97.953 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| XSCALE | data scaling |
| PHENIX | phasing |
| PHENIX | model building |
Entry History & Funding Information
Deposition Data
- Released Date: 2022-02-02 Deposition Author(s): Gill, N.P., Madden, D.R.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) | United States | R01-DK101541 |
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | P20-GM113132 |
| National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) | United States | P30-DK117469 |
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | T32-GM008704 |
Revision History (Full details and data files)
- Version 1.0: 2022-02-02
Type: Initial release - Version 1.1: 2023-10-18
Changes: Data collection, Refinement description - Version 1.2: 2024-11-20
Changes: Structure summary
