7RQ9

Crystal structure of the A2058-dimethylated Thermus thermophilus 70S ribosome in complex with iboxamycin, mRNA, deacylated A- and E-site tRNAs, and aminoacylated P-site tRNA at 2.60A resolution

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.60 Å
  • R-Value Free: 0.298 
  • R-Value Work: 0.241 
  • R-Value Observed: 0.244 

Starting Model: experimental
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This is version 1.3 of the entry. See complete history. 


Literature

A synthetic antibiotic class overcoming bacterial multidrug resistance.

Mitcheltree, M.J., Pisipati, A., Syroegin, E.A., Silvestre, K.J., Klepacki, D., Mason, J.D., Terwilliger, D.W., Testolin, G., Pote, A.R., Wu, K.J.Y., Ladley, R.P., Chatman, K., Mankin, A.S., Polikanov, Y.S., Myers, A.G.

(2021) Nature 599: 507-512

  • DOI: https://doi.org/10.1038/s41586-021-04045-6
  • Primary Citation of Related Structures:  
    7RQ8, 7RQ9

  • PubMed Abstract: 

    The dearth of new medicines effective against antibiotic-resistant bacteria presents a growing global public health concern 1 . For more than five decades, the search for new antibiotics has relied heavily on the chemical modification of natural products (semisynthesis), a method ill-equipped to combat rapidly evolving resistance threats. Semisynthetic modifications are typically of limited scope within polyfunctional antibiotics, usually increase molecular weight, and seldom permit modifications of the underlying scaffold. When properly designed, fully synthetic routes can easily address these shortcomings 2 . Here we report the structure-guided design and component-based synthesis of a rigid oxepanoproline scaffold which, when linked to the aminooctose residue of clindamycin, produces an antibiotic of exceptional potency and spectrum of activity, which we name iboxamycin. Iboxamycin is effective against ESKAPE pathogens including strains expressing Erm and Cfr ribosomal RNA methyltransferase enzymes, products of genes that confer resistance to all clinically relevant antibiotics targeting the large ribosomal subunit, namely macrolides, lincosamides, phenicols, oxazolidinones, pleuromutilins and streptogramins. X-ray crystallographic studies of iboxamycin in complex with the native bacterial ribosome, as well as with the Erm-methylated ribosome, uncover the structural basis for this enhanced activity, including a displacement of the [Formula: see text] nucleotide upon antibiotic binding. Iboxamycin is orally bioavailable, safe and effective in treating both Gram-positive and Gram-negative bacterial infections in mice, attesting to the capacity for chemical synthesis to provide new antibiotics in an era of increasing resistance.

    • Organizational Affiliation: 

    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.


Macromolecules

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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L2C [auth 1D],
GB [auth 2D]		276Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L3D [auth 1E],
HB [auth 2E]		206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 5
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L4E [auth 1F],
IB [auth 2F]		210Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 6
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L5F [auth 1G],
JB [auth 2G]		182Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 7
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L6G [auth 1H],
KB [auth 2H]		180Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 8
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L9H [auth 1I],
LB [auth 2I]		148Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 9
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L13I [auth 1N],
MB [auth 2N]		140Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 10
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L14J [auth 1O],
NB [auth 2O]		122Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 11
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L15K [auth 1P],
OB [auth 2P]		150Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 12
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L16L [auth 1Q],
PB [auth 2Q]		141Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 13
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L17M [auth 1R],
QB [auth 2R]		118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 14
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L18N [auth 1S],
RB [auth 2S]		112Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 15
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L19O [auth 1T],
SB [auth 2T]		146Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 16
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L20P [auth 1U],
TB [auth 2U]		118Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 17
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L21Q [auth 1V],
UB [auth 2V]		101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 18
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L22R [auth 1W],
VB [auth 2W]		113Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 19
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L23S [auth 1X],
WB [auth 2X]		96Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 20
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L24T [auth 1Y],
XB [auth 2Y]		110Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 21
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L25U [auth 1Z],
YB [auth 2Z]		206Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 22
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L27V [auth 10],
ZB [auth 20]		85Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 23
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L28AC [auth 21],
W [auth 11]		98Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 24
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L29BC [auth 22],
X [auth 12]		72Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 25
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L30CC [auth 23],
Y [auth 13]		60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 26
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L31DC [auth 24],
Z [auth 14]		71Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 27
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L32AA [auth 15],
EC [auth 25]		60Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 28
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L33BA [auth 16],
FC [auth 26]		54Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 29
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L34CA [auth 17],
GC [auth 27]		49Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 30
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L35DA [auth 18],
HC [auth 28]		65Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 31
MoleculeChains Sequence LengthOrganismDetailsImage
50S ribosomal protein L36EA [auth 19],
IC [auth 29]		37Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 33
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S2GA [auth 1b],
KC [auth 2b]		256Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 34
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S3HA [auth 1c],
LC [auth 2c]		239Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 35
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S4IA [auth 1d],
MC [auth 2d]		209Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 36
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S5JA [auth 1e],
NC [auth 2e]		162Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 37
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S6KA [auth 1f],
OC [auth 2f]		101Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 38
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S7LA [auth 1g],
PC [auth 2g]		156Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 39
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S8MA [auth 1h],
QC [auth 2h]		138Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 40
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S9NA [auth 1i],
RC [auth 2i]		128Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 41
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S10OA [auth 1j],
SC [auth 2j]		105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 42
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S11PA [auth 1k],
TC [auth 2k]		129Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 43
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S12QA [auth 1l],
UC [auth 2l]		132Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 44
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S13RA [auth 1m],
VC [auth 2m]		126Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 45
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S14 type ZSA [auth 1n],
WC [auth 2n]		61Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 46
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S15TA [auth 1o],
XC [auth 2o]		89Thermus thermophilus HB8Mutation(s): 0 
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Find proteins for Q5SJ76 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 47
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S16UA [auth 1p],
YC [auth 2p]		88Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 48
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S17VA [auth 1q],
ZC [auth 2q]		105Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 49
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S18AD [auth 2r],
WA [auth 1r]		88Thermus thermophilus HB8Mutation(s): 0 
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Find proteins for Q5SLQ0 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8))
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Entity ID: 50
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S19BD [auth 2s],
XA [auth 1s]		93Thermus thermophilus HB8Mutation(s): 0 
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Entity ID: 51
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein S20CD [auth 2t],
YA [auth 1t]		106Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 52
MoleculeChains Sequence LengthOrganismDetailsImage
30S ribosomal protein ThxDD [auth 2u],
ZA [auth 1u]		27Thermus thermophilus HB8Mutation(s): 0 
UniProt
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Entity ID: 1
MoleculeChains LengthOrganismImage
23S Ribosomal RNAA [auth 1A],
EB [auth 2A]		2,915Thermus thermophilus HB8
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Entity ID: 2
MoleculeChains LengthOrganismImage
5S Ribosomal RNAB [auth 1B],
FB [auth 2B]		121Thermus thermophilus HB8
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Entity ID: 32
MoleculeChains LengthOrganismImage
16S Ribosomal RNAFA [auth 1a],
JC [auth 2a]		1,521Thermus thermophilus HB8
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Entity ID: 53
MoleculeChains LengthOrganismImage
mRNAAB [auth 1v],
ED [auth 2v]		24Tequatrovirus T4
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Entity ID: 54
MoleculeChains LengthOrganismImage
A-site tRNABB [auth 1w],
FD [auth 2w]		76Escherichia coli
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Entity ID: 55
MoleculeChains LengthOrganismImage
P-site tRNACB [auth 1x],
GD [auth 2x]		77Escherichia coli
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Entity ID: 56
MoleculeChains LengthOrganismImage
E-site tRNADB [auth 1y],
HD [auth 2y]		76Escherichia coli
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Small Molecules
Ligands 5 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
6IF
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ETA [auth 1A],
ZRC [auth 2A]		methyl 7-chloro-6,7,8-trideoxy-6-{[(4S,5aS,8S,8aR)-4-(2-methylpropyl)octahydro-2H-oxepino[2,3-c]pyrrole-8-carbonyl]amino}-1-thio-L-threo-alpha-D-galacto-octopyranoside
C22 H39 Cl N2 O6 S
JPCLUJPDWMBCAA-SUTQZAMLSA-N
SF4
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DED [auth 2d],
MJB [auth 1d]		IRON/SULFUR CLUSTER
Fe4 S4
LJBDFODJNLIPKO-UHFFFAOYSA-N
ZN
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AZA [auth 1Y]
FVC [auth 29]
GAB [auth 14]
HBB [auth 19]
KUC [auth 2Y]
AZA [auth 1Y],
FVC [auth 29],
GAB [auth 14],
HBB [auth 19],
KUC [auth 2Y],
PED [auth 2n],
QAB [auth 15],
SAB [auth 16],
SUC [auth 24],
XJB [auth 1n],
XUC [auth 25],
ZUC [auth 26]
ZINC ION
Zn
PTFCDOFLOPIGGS-UHFFFAOYSA-N
K
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CCC [auth 2A],
VY [auth 1A]		POTASSIUM ION
K
NPYPAHLBTDXSSS-UHFFFAOYSA-N
MG
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AAA [auth 1A]
AAB [auth 13]
AAC [auth 2A]
AAD [auth 2a]
ABA [auth 1A]
AAA [auth 1A],
AAB [auth 13],
AAC [auth 2A],
AAD [auth 2a],
ABA [auth 1A],
ABB [auth 17],
ABC [auth 2A],
ABD [auth 2a],
ACA [auth 1A],
ACB [auth 1a],
ACC [auth 2A],
ACD [auth 2a],
ADA [auth 1A],
ADB [auth 1a],
ADC [auth 2A],
ADD [auth 2a],
AE [auth 1A],
AEA [auth 1A],
AEB [auth 1a],
AEC [auth 2A],
AED [auth 2a],
AF [auth 1A],
AFA [auth 1A],
AFB [auth 1a],
AFC [auth 2A],
AFD [auth 2w],
AG [auth 1A],
AGA [auth 1A],
AGB [auth 1a],
AGC [auth 2A],
AH [auth 1A],
AHA [auth 1A],
AHB [auth 1a],
AHC [auth 2A],
AI [auth 1A],
AIA [auth 1A],
AIB [auth 1a],
AIC [auth 2A],
AJ [auth 1A],
AJA [auth 1A],
AJB [auth 1a],
AJC [auth 2A],
AK [auth 1A],
AKA [auth 1A],
AKB [auth 1v],
AKC [auth 2A],
AL [auth 1A],
ALA [auth 1A],
ALB [auth 1y],
ALC [auth 2A],
AM [auth 1A],
AMA [auth 1A],
AMB [auth 2A],
AMC [auth 2A],
AN [auth 1A],
ANA [auth 1A],
ANB [auth 2A],
ANC [auth 2A],
AO [auth 1A],
AOA [auth 1A],
AOB [auth 2A],
AOC [auth 2A],
AP [auth 1A],
APA [auth 1A],
APB [auth 2A],
APC [auth 2A],
AQ [auth 1A],
AQA [auth 1A],
AQB [auth 2A],
AQC [auth 2A],
AR [auth 1A],
ARA [auth 1A],
ARB [auth 2A],
ARC [auth 2A],
AS [auth 1A],
ASA [auth 1A],
ASB [auth 2A],
ASC [auth 2B],
AT [auth 1A],
ATA [auth 1A],
ATB [auth 2A],
ATC [auth 2E],
AU [auth 1A],
AUA [auth 1B],
AUB [auth 2A],
AUC [auth 2T],
AV [auth 1A],
AVA [auth 1E],
AVB [auth 2A],
AVC [auth 27],
AW [auth 1A],
AWA [auth 1F],
AWB [auth 2A],
AWC [auth 2a],
AX [auth 1A],
AXA [auth 1Q],
AXB [auth 2A],
AXC [auth 2a],
AY [auth 1A],
AYA [auth 1V],
AYB [auth 2A],
AYC [auth 2a],
AZ [auth 1A],
AZB [auth 2A],
AZC [auth 2a],
BAA [auth 1A],
BAB [auth 13],
BAC [auth 2A],
BAD [auth 2a],
BBA [auth 1A],
BBB [auth 18],
BBC [auth 2A],
BBD [auth 2a],
BCA [auth 1A],
BCB [auth 1a],
BCC [auth 2A],
BCD [auth 2a],
BDA [auth 1A],
BDB [auth 1a],
BDC [auth 2A],
BDD [auth 2a],
BE [auth 1A],
BEA [auth 1A],
BEB [auth 1a],
BEC [auth 2A],
BED [auth 2a],
BF [auth 1A],
BFA [auth 1A],
BFB [auth 1a],
BFC [auth 2A],
BFD [auth 2w],
BG [auth 1A],
BGA [auth 1A],
BGB [auth 1a],
BGC [auth 2A],
BH [auth 1A],
BHA [auth 1A],
BHB [auth 1a],
BHC [auth 2A],
BI [auth 1A],
BIA [auth 1A],
BIB [auth 1a],
BIC [auth 2A],
BJ [auth 1A],
BJA [auth 1A],
BJB [auth 1a],
BJC [auth 2A],
BK [auth 1A],
BKA [auth 1A],
BKB [auth 1v],
BKC [auth 2A],
BL [auth 1A],
BLA [auth 1A],
BLB [auth 2A],
BLC [auth 2A],
BM [auth 1A],
BMA [auth 1A],
BMB [auth 2A],
BMC [auth 2A],
BN [auth 1A],
BNA [auth 1A],
BNB [auth 2A],
BNC [auth 2A],
BO [auth 1A],
BOA [auth 1A],
BOB [auth 2A],
BOC [auth 2A],
BP [auth 1A],
BPA [auth 1A],
BPB [auth 2A],
BPC [auth 2A],
BQ [auth 1A],
BQA [auth 1A],
BQB [auth 2A],
BQC [auth 2A],
BR [auth 1A],
BRA [auth 1A],
BRB [auth 2A],
BRC [auth 2A],
BS [auth 1A],
BSA [auth 1A],
BSB [auth 2A],
BSC [auth 2B],
BT [auth 1A],
BTA [auth 1A],
BTB [auth 2A],
BTC [auth 2E],
BU [auth 1A],
BUA [auth 1B],
BUB [auth 2A],
BUC [auth 2T],
BV [auth 1A],
BVA [auth 1E],
BVB [auth 2A],
BVC [auth 27],
BW [auth 1A],
BWA [auth 1F],
BWB [auth 2A],
BWC [auth 2a],
BX [auth 1A],
BXA [auth 1Q],
BXB [auth 2A],
BXC [auth 2a],
BY [auth 1A],
BYA [auth 1V],
BYB [auth 2A],
BYC [auth 2a],
BZ [auth 1A],
BZA [auth 1Z],
BZB [auth 2A],
BZC [auth 2a],
CAA [auth 1A],
CAB [auth 13],
CAC [auth 2A],
CAD [auth 2a],
CBA [auth 1A],
CBB [auth 18],
CBC [auth 2A],
CBD [auth 2a],
CCA [auth 1A],
CCB [auth 1a],
CCD [auth 2a],
CDA [auth 1A],
CDB [auth 1a],
CDC [auth 2A],
CDD [auth 2a],
CE [auth 1A],
CEA [auth 1A],
CEB [auth 1a],
CEC [auth 2A],
CED [auth 2d],
CF [auth 1A],
CFA [auth 1A],
CFB [auth 1a],
CFC [auth 2A],
CFD [auth 2w],
CG [auth 1A],
CGA [auth 1A],
CGB [auth 1a],
CGC [auth 2A],
CH [auth 1A],
CHA [auth 1A],
CHB [auth 1a],
CHC [auth 2A],
CI [auth 1A],
CIA [auth 1A],
CIB [auth 1a],
CIC [auth 2A],
CJ [auth 1A],
CJA [auth 1A],
CJB [auth 1a],
CJC [auth 2A],
CK [auth 1A],
CKA [auth 1A],
CKB [auth 1w],
CKC [auth 2A],
CL [auth 1A],
CLA [auth 1A],
CLB [auth 2A],
CLC [auth 2A],
CM [auth 1A],
CMA [auth 1A],
CMB [auth 2A],
CMC [auth 2A],
CN [auth 1A],
CNA [auth 1A],
CNB [auth 2A],
CNC [auth 2A],
CO [auth 1A],
COA [auth 1A],
COB [auth 2A],
COC [auth 2A],
CP [auth 1A],
CPA [auth 1A],
CPB [auth 2A],
CPC [auth 2A],
CQ [auth 1A],
CQA [auth 1A],
CQB [auth 2A],
CQC [auth 2A],
CR [auth 1A],
CRA [auth 1A],
CRB [auth 2A],
CRC [auth 2A],
CS [auth 1A],
CSA [auth 1A],
CSB [auth 2A],
CSC [auth 2B],
CT [auth 1A],
CTA [auth 1A],
CTB [auth 2A],
CTC [auth 2E],
CU [auth 1A],
CUA [auth 1B],
CUB [auth 2A],
CUC [auth 2T],
CV [auth 1A],
CVA [auth 1E],
CVB [auth 2A],
CVC [auth 28],
CW [auth 1A],
CWA [auth 1G],
CWB [auth 2A],
CWC [auth 2a],
CX [auth 1A],
CXA [auth 1Q],
CXB [auth 2A],
CXC [auth 2a],
CY [auth 1A],
CYA [auth 1V],
CYB [auth 2A],
CYC [auth 2a],
CZ [auth 1A],
CZA [auth 1Z],
CZB [auth 2A],
CZC [auth 2a],
DAA [auth 1A],
DAB [auth 13],
DAC [auth 2A],
DAD [auth 2a],
DBA [auth 1A],
DBB [auth 18],
DBC [auth 2A],
DBD [auth 2a],
DCA [auth 1A],
DCB [auth 1a],
DCC [auth 2A],
DCD [auth 2a],
DDA [auth 1A],
DDB [auth 1a],
DDC [auth 2A],
DDD [auth 2a],
DE [auth 1A],
DEA [auth 1A],
DEB [auth 1a],
DEC [auth 2A],
DF [auth 1A],
DFA [auth 1A],
DFB [auth 1a],
DFC [auth 2A],
DFD [auth 2w],
DG [auth 1A],
DGA [auth 1A],
DGB [auth 1a],
DGC [auth 2A],
DH [auth 1A],
DHA [auth 1A],
DHB [auth 1a],
DHC [auth 2A],
DI [auth 1A],
DIA [auth 1A],
DIB [auth 1a],
DIC [auth 2A],
DJ [auth 1A],
DJA [auth 1A],
DJB [auth 1a],
DJC [auth 2A],
DK [auth 1A],
DKA [auth 1A],
DKB [auth 1w],
DKC [auth 2A],
DL [auth 1A],
DLA [auth 1A],
DLB [auth 2A],
DLC [auth 2A],
DM [auth 1A],
DMA [auth 1A],
DMB [auth 2A],
DMC [auth 2A],
DN [auth 1A],
DNA [auth 1A],
DNB [auth 2A],
DNC [auth 2A],
DO [auth 1A],
DOA [auth 1A],
DOB [auth 2A],
DOC [auth 2A],
DP [auth 1A],
DPA [auth 1A],
DPB [auth 2A],
DPC [auth 2A],
DQ [auth 1A],
DQA [auth 1A],
DQB [auth 2A],
DQC [auth 2A],
DR [auth 1A],
DRA [auth 1A],
DRB [auth 2A],
DRC [auth 2A],
DS [auth 1A],
DSA [auth 1A],
DSB [auth 2A],
DSC [auth 2B],
DT [auth 1A],
DTA [auth 1A],
DTB [auth 2A],
DTC [auth 2E],
DU [auth 1A],
DUA [auth 1B],
DUB [auth 2A],
DUC [auth 2U],
DV [auth 1A],
DVA [auth 1E],
DVB [auth 2A],
DVC [auth 28],
DW [auth 1A],
DWA [auth 1G],
DWB [auth 2A],
DWC [auth 2a],
DX [auth 1A],
DXA [auth 1R],
DXB [auth 2A],
DXC [auth 2a],
DY [auth 1A],
DYA [auth 1V],
DYB [auth 2A],
DYC [auth 2a],
DZ [auth 1A],
DZA [auth 1Z],
DZB [auth 2A],
DZC [auth 2a],
EAA [auth 1A],
EAB [auth 13],
EAC [auth 2A],
EAD [auth 2a],
EBA [auth 1A],
EBB [auth 18],
EBC [auth 2A],
EBD [auth 2a],
ECA [auth 1A],
ECB [auth 1a],
ECC [auth 2A],
ECD [auth 2a],
EDA [auth 1A],
EDB [auth 1a],
EDC [auth 2A],
EDD [auth 2a],
EE [auth 1A],
EEA [auth 1A],
EEB [auth 1a],
EEC [auth 2A],
EED [auth 2e],
EF [auth 1A],
EFA [auth 1A],
EFB [auth 1a],
EFC [auth 2A],
EFD [auth 2w],
EG [auth 1A],
EGA [auth 1A],
EGB [auth 1a],
EGC [auth 2A],
EH [auth 1A],
EHA [auth 1A],
EHB [auth 1a],
EHC [auth 2A],
EI [auth 1A],
EIA [auth 1A],
EIB [auth 1a],
EIC [auth 2A],
EJ [auth 1A],
EJA [auth 1A],
EJB [auth 1a],
EJC [auth 2A],
EK [auth 1A],
EKA [auth 1A],
EKB [auth 1w],
EKC [auth 2A],
EL [auth 1A],
ELA [auth 1A],
ELB [auth 2A],
ELC [auth 2A],
EM [auth 1A],
EMA [auth 1A],
EMB [auth 2A],
EMC [auth 2A],
EN [auth 1A],
ENA [auth 1A],
ENB [auth 2A],
ENC [auth 2A],
EO [auth 1A],
EOA [auth 1A],
EOB [auth 2A],
EOC [auth 2A],
EP [auth 1A],
EPA [auth 1A],
EPB [auth 2A],
EPC [auth 2A],
EQ [auth 1A],
EQA [auth 1A],
EQB [auth 2A],
EQC [auth 2A],
ER [auth 1A],
ERA [auth 1A],
ERB [auth 2A],
ERC [auth 2A],
ES [auth 1A],
ESA [auth 1A],
ESB [auth 2A],
ESC [auth 2B],
ET [auth 1A],
ETB [auth 2A],
ETC [auth 2E],
EU [auth 1A],
EUA [auth 1B],
EUB [auth 2A],
EUC [auth 2U],
EV [auth 1A],
EVA [auth 1E],
EVB [auth 2A],
EVC [auth 28],
EW [auth 1A],
EWA [auth 1G],
EWB [auth 2A],
EWC [auth 2a],
EX [auth 1A],
EXA [auth 1R],
EXB [auth 2A],
EXC [auth 2a],
EY [auth 1A],
EYA [auth 1V],
EYB [auth 2A],
EYC [auth 2a],
EZ [auth 1A],
EZA [auth 1Z],
EZB [auth 2A],
EZC [auth 2a],
FAA [auth 1A],
FAB [auth 14],
FAC [auth 2A],
FAD [auth 2a],
FBA [auth 1A],
FBB [auth 18],
FBC [auth 2A],
FBD [auth 2a],
FCA [auth 1A],
FCB [auth 1a],
FCC [auth 2A],
FCD [auth 2a],
FDA [auth 1A],
FDB [auth 1a],
FDC [auth 2A],
FDD [auth 2a],
FE [auth 1A],
FEA [auth 1A],
FEB [auth 1a],
FEC [auth 2A],
FED [auth 2f],
FF [auth 1A],
FFA [auth 1A],
FFB [auth 1a],
FFC [auth 2A],
FFD [auth 2x],
FG [auth 1A],
FGA [auth 1A],
FGB [auth 1a],
FGC [auth 2A],
FH [auth 1A],
FHA [auth 1A],
FHB [auth 1a],
FHC [auth 2A],
FI [auth 1A],
FIA [auth 1A],
FIB [auth 1a],
FIC [auth 2A],
FJ [auth 1A],
FJA [auth 1A],
FJB [auth 1a],
FJC [auth 2A],
FK [auth 1A],
FKA [auth 1A],
FKB [auth 1w],
FKC [auth 2A],
FL [auth 1A],
FLA [auth 1A],
FLB [auth 2A],
FLC [auth 2A],
FM [auth 1A],
FMA [auth 1A],
FMB [auth 2A],
FMC [auth 2A],
FN [auth 1A],
FNA [auth 1A],
FNB [auth 2A],
FNC [auth 2A],
FO [auth 1A],
FOA [auth 1A],
FOB [auth 2A],
FOC [auth 2A],
FP [auth 1A],
FPA [auth 1A],
FPB [auth 2A],
FPC [auth 2A],
FQ [auth 1A],
FQA [auth 1A],
FQB [auth 2A],
FQC [auth 2A],
FR [auth 1A],
FRA [auth 1A],
FRB [auth 2A],
FRC [auth 2A],
FS [auth 1A],
FSA [auth 1A],
FSB [auth 2A],
FSC [auth 2B],
FT [auth 1A],
FTA [auth 1B],
FTB [auth 2A],
FTC [auth 2E],
FU [auth 1A],
FUA [auth 1B],
FUB [auth 2A],
FUC [auth 2V],
FV [auth 1A],
FVA [auth 1E],
FVB [auth 2A],
FW [auth 1A],
FWA [auth 1G],
FWB [auth 2A],
FWC [auth 2a],
FX [auth 1A],
FXA [auth 1R],
FXB [auth 2A],
FXC [auth 2a],
FY [auth 1A],
FYA [auth 1V],
FYB [auth 2A],
FYC [auth 2a],
FZ [auth 1A],
FZA [auth 1Z],
FZB [auth 2A],
FZC [auth 2a],
GAA [auth 1A],
GAC [auth 2A],
GAD [auth 2a],
GBA [auth 1A],
GBB [auth 19],
GBC [auth 2A],
GBD [auth 2a],
GCA [auth 1A],
GCB [auth 1a],
GCC [auth 2A],
GCD [auth 2a],
GDA [auth 1A],
GDB [auth 1a],
GDC [auth 2A],
GDD [auth 2a],
GE [auth 1A],
GEA [auth 1A],
GEB [auth 1a],
GEC [auth 2A],
GED [auth 2f],
GF [auth 1A],
GFA [auth 1A],
GFB [auth 1a],
GFC [auth 2A],
GFD [auth 2x],
GG [auth 1A],
GGA [auth 1A],
GGB [auth 1a],
GGC [auth 2A],
GH [auth 1A],
GHA [auth 1A],
GHB [auth 1a],
GHC [auth 2A],
GI [auth 1A],
GIA [auth 1A],
GIB [auth 1a],
GIC [auth 2A],
GJ [auth 1A],
GJA [auth 1A],
GJB [auth 1a],
GJC [auth 2A],
GK [auth 1A],
GKA [auth 1A],
GKB [auth 1w],
GKC [auth 2A],
GL [auth 1A],
GLA [auth 1A],
GLB [auth 2A],
GLC [auth 2A],
GM [auth 1A],
GMA [auth 1A],
GMB [auth 2A],
GMC [auth 2A],
GN [auth 1A],
GNA [auth 1A],
GNB [auth 2A],
GNC [auth 2A],
GO [auth 1A],
GOA [auth 1A],
GOB [auth 2A],
GOC [auth 2A],
GP [auth 1A],
GPA [auth 1A],
GPB [auth 2A],
GPC [auth 2A],
GQ [auth 1A],
GQA [auth 1A],
GQB [auth 2A],
GQC [auth 2A],
GR [auth 1A],
GRA [auth 1A],
GRB [auth 2A],
GRC [auth 2A],
GS [auth 1A],
GSA [auth 1A],
GSB [auth 2A],
GSC [auth 2B],
GT [auth 1A],
GTA [auth 1B],
GTB [auth 2A],
GTC [auth 2F],
GU [auth 1A],
GUA [auth 1B],
GUB [auth 2A],
GUC [auth 2V],
GV [auth 1A],
GVA [auth 1E],
GVB [auth 2A],
GVC [auth 2a],
GW [auth 1A],
GWA [auth 1G],
GWB [auth 2A],
GWC [auth 2a],
GX [auth 1A],
GXA [auth 1R],
GXB [auth 2A],
GXC [auth 2a],
GY [auth 1A],
GYA [auth 1W],
GYB [auth 2A],
GYC [auth 2a],
GZ [auth 1A],
GZA [auth 10],
GZB [auth 2A],
GZC [auth 2a],
HAA [auth 1A],
HAB [auth 15],
HAC [auth 2A],
HAD [auth 2a],
HBA [auth 1A],
HBC [auth 2A],
HBD [auth 2a],
HCA [auth 1A],
HCB [auth 1a],
HCC [auth 2A],
HCD [auth 2a],
HDA [auth 1A],
HDB [auth 1a],
HDC [auth 2A],
HDD [auth 2a],
HE [auth 1A],
HEA [auth 1A],
HEB [auth 1a],
HEC [auth 2A],
HED [auth 2g],
HF [auth 1A],
HFA [auth 1A],
HFB [auth 1a],
HFC [auth 2A],
HFD [auth 2x],
HG [auth 1A],
HGA [auth 1A],
HGB [auth 1a],
HGC [auth 2A],
HH [auth 1A],
HHA [auth 1A],
HHB [auth 1a],
HHC [auth 2A],
HI [auth 1A],
HIA [auth 1A],
HIB [auth 1a],
HIC [auth 2A],
HJ [auth 1A],
HJA [auth 1A],
HJB [auth 1a],
HJC [auth 2A],
HK [auth 1A],
HKA [auth 1A],
HKB [auth 1w],
HKC [auth 2A],
HL [auth 1A],
HLA [auth 1A],
HLB [auth 2A],
HLC [auth 2A],
HM [auth 1A],
HMA [auth 1A],
HMB [auth 2A],
HMC [auth 2A],
HN [auth 1A],
HNA [auth 1A],
HNB [auth 2A],
HNC [auth 2A],
HO [auth 1A],
HOA [auth 1A],
HOB [auth 2A],
HOC [auth 2A],
HP [auth 1A],
HPA [auth 1A],
HPB [auth 2A],
HPC [auth 2A],
HQ [auth 1A],
HQA [auth 1A],
HQB [auth 2A],
HQC [auth 2A],
HR [auth 1A],
HRA [auth 1A],
HRB [auth 2A],
HRC [auth 2A],
HS [auth 1A],
HSA [auth 1A],
HSB [auth 2A],
HSC [auth 2B],
HT [auth 1A],
HTA [auth 1B],
HTB [auth 2A],
HTC [auth 2F],
HU [auth 1A],
HUA [auth 1B],
HUB [auth 2A],
HUC [auth 2X],
HV [auth 1A],
HVA [auth 1E],
HVB [auth 2A],
HVC [auth 2a],
HW [auth 1A],
HWA [auth 1I],
HWB [auth 2A],
HWC [auth 2a],
HX [auth 1A],
HXA [auth 1R],
HXB [auth 2A],
HXC [auth 2a],
HY [auth 1A],
HYA [auth 1W],
HYB [auth 2A],
HYC [auth 2a],
HZ [auth 1A],
HZA [auth 10],
HZB [auth 2A],
HZC [auth 2a],
IAA [auth 1A],
IAB [auth 15],
IAC [auth 2A],
IAD [auth 2a],
IBA [auth 1A],
IBB [auth 1a],
IBC [auth 2A],
IBD [auth 2a],
ICA [auth 1A],
ICB [auth 1a],
ICC [auth 2A],
ICD [auth 2a],
ID [auth 1A],
IDA [auth 1A],
IDB [auth 1a],
IDC [auth 2A],
IDD [auth 2a],
IE [auth 1A],
IEA [auth 1A],
IEB [auth 1a],
IEC [auth 2A],
IED [auth 2j],
IF [auth 1A],
IFA [auth 1A],
IFB [auth 1a],
IFC [auth 2A],
IFD [auth 2x],
IG [auth 1A],
IGA [auth 1A],
IGB [auth 1a],
IGC [auth 2A],
IH [auth 1A],
IHA [auth 1A],
IHB [auth 1a],
IHC [auth 2A],
II [auth 1A],
IIA [auth 1A],
IIB [auth 1a],
IIC [auth 2A],
IJ [auth 1A],
IJA [auth 1A],
IJB [auth 1a],
IJC [auth 2A],
IK [auth 1A],
IKA [auth 1A],
IKB [auth 1w],
IKC [auth 2A],
IL [auth 1A],
ILA [auth 1A],
ILB [auth 2A],
ILC [auth 2A],
IM [auth 1A],
IMA [auth 1A],
IMB [auth 2A],
IMC [auth 2A],
IN [auth 1A],
INA [auth 1A],
INB [auth 2A],
INC [auth 2A],
IO [auth 1A],
IOA [auth 1A],
IOB [auth 2A],
IOC [auth 2A],
IP [auth 1A],
IPA [auth 1A],
IPB [auth 2A],
IPC [auth 2A],
IQ [auth 1A],
IQA [auth 1A],
IQB [auth 2A],
IQC [auth 2A],
IR [auth 1A],
IRA [auth 1A],
IRB [auth 2A],
IRC [auth 2A],
IS [auth 1A],
ISA [auth 1A],
ISB [auth 2A],
ISC [auth 2B],
IT [auth 1A],
ITA [auth 1B],
ITB [auth 2A],
ITC [auth 2F],
IU [auth 1A],
IUA [auth 1B],
IUB [auth 2A],
IUC [auth 2X],
IV [auth 1A],
IVA [auth 1E],
IVB [auth 2A],
IVC [auth 2a],
IW [auth 1A],
IWA [auth 1N],
IWB [auth 2A],
IWC [auth 2a],
IX [auth 1A],
IXA [auth 1R],
IXB [auth 2A],
IXC [auth 2a],
IY [auth 1A],
IYA [auth 1W],
IYB [auth 2A],
IYC [auth 2a],
IZ [auth 1A],
IZA [auth 10],
IZB [auth 2A],
IZC [auth 2a],
JAA [auth 1A],
JAB [auth 15],
JAC [auth 2A],
JAD [auth 2a],
JBA [auth 1A],
JBB [auth 1a],
JBC [auth 2A],
JBD [auth 2a],
JCA [auth 1A],
JCB [auth 1a],
JCC [auth 2A],
JCD [auth 2a],
JD [auth 1A],
JDA [auth 1A],
JDB [auth 1a],
JDC [auth 2A],
JDD [auth 2a],
JE [auth 1A],
JEA [auth 1A],
JEB [auth 1a],
JEC [auth 2A],
JED [auth 2k],
JF [auth 1A],
JFA [auth 1A],
JFB [auth 1a],
JFC [auth 2A],
JFD [auth 2x],
JG [auth 1A],
JGA [auth 1A],
JGB [auth 1a],
JGC [auth 2A],
JH [auth 1A],
JHA [auth 1A],
JHB [auth 1a],
JHC [auth 2A],
JI [auth 1A],
JIA [auth 1A],
JIB [auth 1a],
JIC [auth 2A],
JJ [auth 1A],
JJA [auth 1A],
JJB [auth 1a],
JJC [auth 2A],
JK [auth 1A],
JKA [auth 1A],
JKB [auth 1w],
JKC [auth 2A],
JL [auth 1A],
JLA [auth 1A],
JLB [auth 2A],
JLC [auth 2A],
JM [auth 1A],
JMA [auth 1A],
JMB [auth 2A],
JMC [auth 2A],
JN [auth 1A],
JNA [auth 1A],
JNB [auth 2A],
JNC [auth 2A],
JO [auth 1A],
JOA [auth 1A],
JOB [auth 2A],
JOC [auth 2A],
JP [auth 1A],
JPA [auth 1A],
JPB [auth 2A],
JPC [auth 2A],
JQ [auth 1A],
JQA [auth 1A],
JQB [auth 2A],
JQC [auth 2A],
JR [auth 1A],
JRA [auth 1A],
JRB [auth 2A],
JRC [auth 2A],
JS [auth 1A],
JSA [auth 1A],
JSB [auth 2A],
JSC [auth 2B],
JT [auth 1A],
JTA [auth 1B],
JTB [auth 2A],
JTC [auth 2F],
JU [auth 1A],
JUA [auth 1B],
JUB [auth 2A],
JUC [auth 2X],
JV [auth 1A],
JVA [auth 1E],
JVB [auth 2A],
JVC [auth 2a],
JW [auth 1A],
JWA [auth 1N],
JWB [auth 2A],
JWC [auth 2a],
JX [auth 1A],
JXA [auth 1S],
JXB [auth 2A],
JXC [auth 2a],
JY [auth 1A],
JYA [auth 1W],
JYB [auth 2A],
JYC [auth 2a],
JZ [auth 1A],
JZA [auth 10],
JZB [auth 2A],
JZC [auth 2a],
KAA [auth 1A],
KAB [auth 15],
KAC [auth 2A],
KAD [auth 2a],
KBA [auth 1A],
KBB [auth 1a],
KBC [auth 2A],
KBD [auth 2a],
KCA [auth 1A],
KCB [auth 1a],
KCC [auth 2A],
KCD [auth 2a],
KD [auth 1A],
KDA [auth 1A],
KDB [auth 1a],
KDC [auth 2A],
KDD [auth 2a],
KE [auth 1A],
KEA [auth 1A],
KEB [auth 1a],
KEC [auth 2A],
KED [auth 2l],
KF [auth 1A],
KFA [auth 1A],
KFB [auth 1a],
KFC [auth 2A],
KFD [auth 2x],
KG [auth 1A],
KGA [auth 1A],
KGB [auth 1a],
KGC [auth 2A],
KH [auth 1A],
KHA [auth 1A],
KHB [auth 1a],
KHC [auth 2A],
KI [auth 1A],
KIA [auth 1A],
KIB [auth 1a],
KIC [auth 2A],
KJ [auth 1A],
KJA [auth 1A],
KJB [auth 1a],
KJC [auth 2A],
KK [auth 1A],
KKA [auth 1A],
KKB [auth 1w],
KKC [auth 2A],
KL [auth 1A],
KLA [auth 1A],
KLB [auth 2A],
KLC [auth 2A],
KM [auth 1A],
KMA [auth 1A],
KMB [auth 2A],
KMC [auth 2A],
KN [auth 1A],
KNA [auth 1A],
KNB [auth 2A],
KNC [auth 2A],
KO [auth 1A],
KOA [auth 1A],
KOB [auth 2A],
KOC [auth 2A],
KP [auth 1A],
KPA [auth 1A],
KPB [auth 2A],
KPC [auth 2A],
KQ [auth 1A],
KQA [auth 1A],
KQB [auth 2A],
KQC [auth 2A],
KR [auth 1A],
KRA [auth 1A],
KRB [auth 2A],
KRC [auth 2A],
KS [auth 1A],
KSA [auth 1A],
KSB [auth 2A],
KSC [auth 2B],
KT [auth 1A],
KTA [auth 1B],
KTB [auth 2A],
KTC [auth 2F],
KU [auth 1A],
KUA [auth 1B],
KUB [auth 2A],
KV [auth 1A],
KVA [auth 1E],
KVB [auth 2A],
KVC [auth 2a],
KW [auth 1A],
KWA [auth 1N],
KWB [auth 2A],
KWC [auth 2a],
KX [auth 1A],
KXA [auth 1S],
KXB [auth 2A],
KXC [auth 2a],
KY [auth 1A],
KYA [auth 1W],
KYB [auth 2A],
KYC [auth 2a],
KZ [auth 1A],
KZA [auth 10],
KZB [auth 2A],
KZC [auth 2a],
LAA [auth 1A],
LAB [auth 15],
LAC [auth 2A],
LAD [auth 2a],
LBA [auth 1A],
LBB [auth 1a],
LBC [auth 2A],
LBD [auth 2a],
LCA [auth 1A],
LCB [auth 1a],
LCC [auth 2A],
LCD [auth 2a],
LD [auth 1A],
LDA [auth 1A],
LDB [auth 1a],
LDC [auth 2A],
LDD [auth 2a],
LE [auth 1A],
LEA [auth 1A],
LEB [auth 1a],
LEC [auth 2A],
LED [auth 2l],
LF [auth 1A],
LFA [auth 1A],
LFB [auth 1a],
LFC [auth 2A],
LFD [auth 2y],
LG [auth 1A],
LGA [auth 1A],
LGB [auth 1a],
LGC [auth 2A],
LH [auth 1A],
LHA [auth 1A],
LHB [auth 1a],
LHC [auth 2A],
LI [auth 1A],
LIA [auth 1A],
LIB [auth 1a],
LIC [auth 2A],
LJ [auth 1A],
LJA [auth 1A],
LJB [auth 1b],
LJC [auth 2A],
LK [auth 1A],
LKA [auth 1A],
LKB [auth 1x],
LKC [auth 2A],
LL [auth 1A],
LLA [auth 1A],
LLB [auth 2A],
LLC [auth 2A],
LM [auth 1A],
LMA [auth 1A],
LMB [auth 2A],
LMC [auth 2A],
LN [auth 1A],
LNA [auth 1A],
LNB [auth 2A],
LNC [auth 2A],
LO [auth 1A],
LOA [auth 1A],
LOB [auth 2A],
LOC [auth 2A],
LP [auth 1A],
LPA [auth 1A],
LPB [auth 2A],
LPC [auth 2A],
LQ [auth 1A],
LQA [auth 1A],
LQB [auth 2A],
LQC [auth 2A],
LR [auth 1A],
LRA [auth 1A],
LRB [auth 2A],
LRC [auth 2A],
LS [auth 1A],
LSA [auth 1A],
LSB [auth 2A],
LSC [auth 2B],
LT [auth 1A],
LTA [auth 1B],
LTB [auth 2A],
LTC [auth 2F],
LU [auth 1A],
LUA [auth 1B],
LUB [auth 2A],
LUC [auth 2Z],
LV [auth 1A],
LVA [auth 1E],
LVB [auth 2A],
LVC [auth 2a],
LW [auth 1A],
LWA [auth 1N],
LWB [auth 2A],
LWC [auth 2a],
LX [auth 1A],
LXA [auth 1S],
LXB [auth 2A],
LXC [auth 2a],
LY [auth 1A],
LYA [auth 1W],
LYB [auth 2A],
LYC [auth 2a],
LZ [auth 1A],
LZA [auth 10],
LZB [auth 2A],
LZC [auth 2a],
MAA [auth 1A],
MAB [auth 15],
MAC [auth 2A],
MAD [auth 2a],
MBA [auth 1A],
MBB [auth 1a],
MBC [auth 2A],
MBD [auth 2a],
MCA [auth 1A],
MCB [auth 1a],
MCC [auth 2A],
MCD [auth 2a],
MD [auth 1A],
MDA [auth 1A],
MDB [auth 1a],
MDC [auth 2A],
MDD [auth 2a],
ME [auth 1A],
MEA [auth 1A],
MEB [auth 1a],
MEC [auth 2A],
MED [auth 2l],
MF [auth 1A],
MFA [auth 1A],
MFB [auth 1a],
MFC [auth 2A],
MFD [auth 2y],
MG [auth 1A],
MGA [auth 1A],
MGB [auth 1a],
MGC [auth 2A],
MH [auth 1A],
MHA [auth 1A],
MHB [auth 1a],
MHC [auth 2A],
MI [auth 1A],
MIA [auth 1A],
MIB [auth 1a],
MIC [auth 2A],
MJ [auth 1A],
MJA [auth 1A],
MJC [auth 2A],
MK [auth 1A],
MKA [auth 1A],
MKB [auth 1x],
MKC [auth 2A],
ML [auth 1A],
MLA [auth 1A],
MLB [auth 2A],
MLC [auth 2A],
MM [auth 1A],
MMA [auth 1A],
MMB [auth 2A],
MMC [auth 2A],
MN [auth 1A],
MNA [auth 1A],
MNB [auth 2A],
MNC [auth 2A],
MO [auth 1A],
MOA [auth 1A],
MOB [auth 2A],
MOC [auth 2A],
MP [auth 1A],
MPA [auth 1A],
MPB [auth 2A],
MPC [auth 2A],
MQ [auth 1A],
MQA [auth 1A],
MQB [auth 2A],
MQC [auth 2A],
MR [auth 1A],
MRA [auth 1A],
MRB [auth 2A],
MRC [auth 2A],
MS [auth 1A],
MSA [auth 1A],
MSB [auth 2A],
MSC [auth 2B],
MT [auth 1A],
MTA [auth 1B],
MTB [auth 2A],
MTC [auth 2F],
MU [auth 1A],
MUA [auth 1B],
MUB [auth 2A],
MUC [auth 20],
MV [auth 1A],
MVA [auth 1E],
MVB [auth 2A],
MVC [auth 2a],
MW [auth 1A],
MWA [auth 1N],
MWB [auth 2A],
MWC [auth 2a],
MX [auth 1A],
MXA [auth 1T],
MXB [auth 2A],
MXC [auth 2a],
MY [auth 1A],
MYA [auth 1W],
MYB [auth 2A],
MYC [auth 2a],
MZ [auth 1A],
MZA [auth 10],
MZB [auth 2A],
MZC [auth 2a],
NAA [auth 1A],
NAB [auth 15],
NAC [auth 2A],
NAD [auth 2a],
NBA [auth 1A],
NBB [auth 1a],
NBC [auth 2A],
NBD [auth 2a],
NCA [auth 1A],
NCB [auth 1a],
NCC [auth 2A],
NCD [auth 2a],
ND [auth 1A],
NDA [auth 1A],
NDB [auth 1a],
NDC [auth 2A],
NDD [auth 2a],
NE [auth 1A],
NEA [auth 1A],
NEB [auth 1a],
NEC [auth 2A],
NED [auth 2l],
NF [auth 1A],
NFA [auth 1A],
NFB [auth 1a],
NFC [auth 2A],
NFD [auth 2y],
NG [auth 1A],
NGA [auth 1A],
NGB [auth 1a],
NGC [auth 2A],
NH [auth 1A],
NHA [auth 1A],
NHB [auth 1a],
NHC [auth 2A],
NI [auth 1A],
NIA [auth 1A],
NIB [auth 1a],
NIC [auth 2A],
NJ [auth 1A],
NJA [auth 1A],
NJB [auth 1e],
NJC [auth 2A],
NK [auth 1A],
NKA [auth 1A],
NKB [auth 1x],
NKC [auth 2A],
NL [auth 1A],
NLA [auth 1A],
NLB [auth 2A],
NLC [auth 2A],
NM [auth 1A],
NMA [auth 1A],
NMB [auth 2A],
NMC [auth 2A],
NN [auth 1A],
NNA [auth 1A],
NNB [auth 2A],
NNC [auth 2A],
NO [auth 1A],
NOA [auth 1A],
NOB [auth 2A],
NOC [auth 2A],
NP [auth 1A],
NPA [auth 1A],
NPB [auth 2A],
NPC [auth 2A],
NQ [auth 1A],
NQA [auth 1A],
NQB [auth 2A],
NQC [auth 2A],
NR [auth 1A],
NRA [auth 1A],
NRB [auth 2A],
NRC [auth 2A],
NS [auth 1A],
NSA [auth 1A],
NSB [auth 2A],
NSC [auth 2B],
NT [auth 1A],
NTA [auth 1B],
NTB [auth 2A],
NTC [auth 2F],
NU [auth 1A],
NUA [auth 1D],
NUB [auth 2A],
NUC [auth 20],
NV [auth 1A],
NVA [auth 1F],
NVB [auth 2A],
NVC [auth 2a],
NW [auth 1A],
NWA [auth 1N],
NWB [auth 2A],
NWC [auth 2a],
NX [auth 1A],
NXA [auth 1T],
NXB [auth 2A],
NXC [auth 2a],
NY [auth 1A],
NYA [auth 1W],
NYB [auth 2A],
NYC [auth 2a],
NZ [auth 1A],
NZA [auth 10],
NZB [auth 2A],
NZC [auth 2a],
OAA [auth 1A],
OAB [auth 15],
OAC [auth 2A],
OAD [auth 2a],
OBA [auth 1A],
OBB [auth 1a],
OBC [auth 2A],
OBD [auth 2a],
OCA [auth 1A],
OCB [auth 1a],
OCC [auth 2A],
OCD [auth 2a],
OD [auth 1A],
ODA [auth 1A],
ODB [auth 1a],
ODC [auth 2A],
ODD [auth 2a],
OE [auth 1A],
OEA [auth 1A],
OEB [auth 1a],
OEC [auth 2A],
OED [auth 2m],
OF [auth 1A],
OFA [auth 1A],
OFB [auth 1a],
OFC [auth 2A],
OFD [auth 2y],
OG [auth 1A],
OGA [auth 1A],
OGB [auth 1a],
OGC [auth 2A],
OH [auth 1A],
OHA [auth 1A],
OHB [auth 1a],
OHC [auth 2A],
OI [auth 1A],
OIA [auth 1A],
OIB [auth 1a],
OIC [auth 2A],
OJ [auth 1A],
OJA [auth 1A],
OJB [auth 1f],
OJC [auth 2A],
OK [auth 1A],
OKA [auth 1A],
OKB [auth 1x],
OKC [auth 2A],
OL [auth 1A],
OLA [auth 1A],
OLB [auth 2A],
OLC [auth 2A],
OM [auth 1A],
OMA [auth 1A],
OMB [auth 2A],
OMC [auth 2A],
ON [auth 1A],
ONA [auth 1A],
ONB [auth 2A],
ONC [auth 2A],
OO [auth 1A],
OOA [auth 1A],
OOB [auth 2A],
OOC [auth 2A],
OP [auth 1A],
OPA [auth 1A],
OPB [auth 2A],
OPC [auth 2A],
OQ [auth 1A],
OQA [auth 1A],
OQB [auth 2A],
OQC [auth 2A],
OR [auth 1A],
ORA [auth 1A],
ORB [auth 2A],
ORC [auth 2A],
OS [auth 1A],
OSA [auth 1A],
OSB [auth 2A],
OSC [auth 2B],
OT [auth 1A],
OTA [auth 1B],
OTB [auth 2A],
OTC [auth 2G],
OU [auth 1A],
OUA [auth 1D],
OUB [auth 2A],
OUC [auth 21],
OV [auth 1A],
OVA [auth 1F],
OVB [auth 2A],
OVC [auth 2a],
OW [auth 1A],
OWA [auth 1O],
OWB [auth 2A],
OWC [auth 2a],
OX [auth 1A],
OXA [auth 1T],
OXB [auth 2A],
OXC [auth 2a],
OY [auth 1A],
OYA [auth 1W],
OYB [auth 2A],
OYC [auth 2a],
OZ [auth 1A],
OZA [auth 10],
OZB [auth 2A],
OZC [auth 2a],
PAA [auth 1A],
PAB [auth 15],
PAC [auth 2A],
PAD [auth 2a],
PBA [auth 1A],
PBB [auth 1a],
PBC [auth 2A],
PBD [auth 2a],
PCA [auth 1A],
PCB [auth 1a],
PCC [auth 2A],
PCD [auth 2a],
PD [auth 1A],
PDA [auth 1A],
PDB [auth 1a],
PDC [auth 2A],
PDD [auth 2a],
PE [auth 1A],
PEA [auth 1A],
PEB [auth 1a],
PEC [auth 2A],
PF [auth 1A],
PFA [auth 1A],
PFB [auth 1a],
PFC [auth 2A],
PFD [auth 2y],
PG [auth 1A],
PGA [auth 1A],
PGB [auth 1a],
PGC [auth 2A],
PH [auth 1A],
PHA [auth 1A],
PHB [auth 1a],
PHC [auth 2A],
PI [auth 1A],
PIA [auth 1A],
PIB [auth 1a],
PIC [auth 2A],
PJ [auth 1A],
PJA [auth 1A],
PJB [auth 1f],
PJC [auth 2A],
PK [auth 1A],
PKA [auth 1A],
PKB [auth 1x],
PKC [auth 2A],
PL [auth 1A],
PLA [auth 1A],
PLB [auth 2A],
PLC [auth 2A],
PM [auth 1A],
PMA [auth 1A],
PMB [auth 2A],
PMC [auth 2A],
PN [auth 1A],
PNA [auth 1A],
PNB [auth 2A],
PNC [auth 2A],
PO [auth 1A],
POA [auth 1A],
POB [auth 2A],
POC [auth 2A],
PP [auth 1A],
PPA [auth 1A],
PPB [auth 2A],
PPC [auth 2A],
PQ [auth 1A],
PQA [auth 1A],
PQB [auth 2A],
PQC [auth 2A],
PR [auth 1A],
PRA [auth 1A],
PRB [auth 2A],
PRC [auth 2A],
PS [auth 1A],
PSA [auth 1A],
PSB [auth 2A],
PSC [auth 2B],
PT [auth 1A],
PTA [auth 1B],
PTB [auth 2A],
PTC [auth 2N],
PU [auth 1A],
PUA [auth 1D],
PUB [auth 2A],
PUC [auth 21],
PV [auth 1A],
PVA [auth 1F],
PVB [auth 2A],
PVC [auth 2a],
PW [auth 1A],
PWA [auth 1O],
PWB [auth 2A],
PWC [auth 2a],
PX [auth 1A],
PXA [auth 1T],
PXB [auth 2A],
PXC [auth 2a],
PY [auth 1A],
PYA [auth 1W],
PYB [auth 2A],
PYC [auth 2a],
PZ [auth 1A],
PZA [auth 11],
PZB [auth 2A],
PZC [auth 2a],
QAA [auth 1A],
QAC [auth 2A],
QAD [auth 2a],
QBA [auth 1A],
QBB [auth 1a],
QBC [auth 2A],
QBD [auth 2a],
QCA [auth 1A],
QCB [auth 1a],
QCC [auth 2A],
QCD [auth 2a],
QD [auth 1A],
QDA [auth 1A],
QDB [auth 1a],
QDC [auth 2A],
QDD [auth 2a],
QE [auth 1A],
QEA [auth 1A],
QEB [auth 1a],
QEC [auth 2A],
QED [auth 2q],
QF [auth 1A],
QFA [auth 1A],
QFB [auth 1a],
QFC [auth 2A],
QFD [auth 2y],
QG [auth 1A],
QGA [auth 1A],
QGB [auth 1a],
QGC [auth 2A],
QH [auth 1A],
QHA [auth 1A],
QHB [auth 1a],
QHC [auth 2A],
QI [auth 1A],
QIA [auth 1A],
QIB [auth 1a],
QIC [auth 2A],
QJ [auth 1A],
QJA [auth 1A],
QJB [auth 1h],
QJC [auth 2A],
QK [auth 1A],
QKA [auth 1A],
QKB [auth 1x],
QKC [auth 2A],
QL [auth 1A],
QLA [auth 1A],
QLB [auth 2A],
QLC [auth 2A],
QM [auth 1A],
QMA [auth 1A],
QMB [auth 2A],
QMC [auth 2A],
QN [auth 1A],
QNA [auth 1A],
QNB [auth 2A],
QNC [auth 2A],
QO [auth 1A],
QOA [auth 1A],
QOB [auth 2A],
QOC [auth 2A],
QP [auth 1A],
QPA [auth 1A],
QPB [auth 2A],
QPC [auth 2A],
QQ [auth 1A],
QQA [auth 1A],
QQB [auth 2A],
QQC [auth 2A],
QR [auth 1A],
QRA [auth 1A],
QRB [auth 2A],
QRC [auth 2A],
QS [auth 1A],
QSA [auth 1A],
QSB [auth 2A],
QSC [auth 2B],
QT [auth 1A],
QTA [auth 1B],
QTB [auth 2A],
QTC [auth 2O],
QU [auth 1A],
QUA [auth 1D],
QUB [auth 2A],
QUC [auth 23],
QV [auth 1A],
QVA [auth 1F],
QVB [auth 2A],
QVC [auth 2a],
QW [auth 1A],
QWA [auth 1O],
QWB [auth 2A],
QWC [auth 2a],
QX [auth 1A],
QXA [auth 1T],
QXB [auth 2A],
QXC [auth 2a],
QY [auth 1A],
QYA [auth 1X],
QYB [auth 2A],
QYC [auth 2a],
QZ [auth 1A],
QZA [auth 11],
QZB [auth 2A],
QZC [auth 2a],
RAA [auth 1A],
RAB [auth 16],
RAC [auth 2A],
RAD [auth 2a],
RBA [auth 1A],
RBB [auth 1a],
RBC [auth 2A],
RBD [auth 2a],
RCA [auth 1A],
RCB [auth 1a],
RCC [auth 2A],
RCD [auth 2a],
RD [auth 1A],
RDA [auth 1A],
RDB [auth 1a],
RDC [auth 2A],
RDD [auth 2a],
RE [auth 1A],
REA [auth 1A],
REB [auth 1a],
REC [auth 2A],
RED [auth 2q],
RF [auth 1A],
RFA [auth 1A],
RFB [auth 1a],
RFC [auth 2A],
RG [auth 1A],
RGA [auth 1A],
RGB [auth 1a],
RGC [auth 2A],
RH [auth 1A],
RHA [auth 1A],
RHB [auth 1a],
RHC [auth 2A],
RI [auth 1A],
RIA [auth 1A],
RIB [auth 1a],
RIC [auth 2A],
RJ [auth 1A],
RJA [auth 1A],
RJB [auth 1k],
RJC [auth 2A],
RK [auth 1A],
RKA [auth 1A],
RKB [auth 1x],
RKC [auth 2A],
RL [auth 1A],
RLA [auth 1A],
RLB [auth 2A],
RLC [auth 2A],
RM [auth 1A],
RMA [auth 1A],
RMB [auth 2A],
RMC [auth 2A],
RN [auth 1A],
RNA [auth 1A],
RNB [auth 2A],
RNC [auth 2A],
RO [auth 1A],
ROA [auth 1A],
ROB [auth 2A],
ROC [auth 2A],
RP [auth 1A],
RPA [auth 1A],
RPB [auth 2A],
RPC [auth 2A],
RQ [auth 1A],
RQA [auth 1A],
RQB [auth 2A],
RQC [auth 2A],
RR [auth 1A],
RRA [auth 1A],
RRB [auth 2A],
RRC [auth 2A],
RS [auth 1A],
RSA [auth 1A],
RSB [auth 2A],
RSC [auth 2B],
RT [auth 1A],
RTA [auth 1B],
RTB [auth 2A],
RTC [auth 2P],
RU [auth 1A],
RUA [auth 1D],
RUB [auth 2A],
RUC [auth 23],
RV [auth 1A],
RVA [auth 1F],
RVB [auth 2A],
RVC [auth 2a],
RW [auth 1A],
RWA [auth 1O],
RWB [auth 2A],
RWC [auth 2a],
RX [auth 1A],
RXA [auth 1U],
RXB [auth 2A],
RXC [auth 2a],
RY [auth 1A],
RYA [auth 1X],
RYB [auth 2A],
RYC [auth 2a],
RZ [auth 1A],
RZA [auth 11],
RZB [auth 2A],
RZC [auth 2a],
SAA [auth 1A],
SAC [auth 2A],
SAD [auth 2a],
SBA [auth 1A],
SBB [auth 1a],
SBC [auth 2A],
SBD [auth 2a],
SCA [auth 1A],
SCB [auth 1a],
SCC [auth 2A],
SCD [auth 2a],
SD [auth 1A],
SDA [auth 1A],
SDB [auth 1a],
SDC [auth 2A],
SDD [auth 2a],
SE [auth 1A],
SEA [auth 1A],
SEB [auth 1a],
SEC [auth 2A],
SED [auth 2r],
SF [auth 1A],
SFA [auth 1A],
SFB [auth 1a],
SFC [auth 2A],
SG [auth 1A],
SGA [auth 1A],
SGB [auth 1a],
SGC [auth 2A],
SH [auth 1A],
SHA [auth 1A],
SHB [auth 1a],
SHC [auth 2A],
SI [auth 1A],
SIA [auth 1A],
SIB [auth 1a],
SIC [auth 2A],
SJ [auth 1A],
SJA [auth 1A],
SJB [auth 1l],
SJC [auth 2A],
SK [auth 1A],
SKA [auth 1A],
SKB [auth 1x],
SKC [auth 2A],
SL [auth 1A],
SLA [auth 1A],
SLB [auth 2A],
SLC [auth 2A],
SM [auth 1A],
SMA [auth 1A],
SMB [auth 2A],
SMC [auth 2A],
SN [auth 1A],
SNA [auth 1A],
SNB [auth 2A],
SNC [auth 2A],
SO [auth 1A],
SOA [auth 1A],
SOB [auth 2A],
SOC [auth 2A],
SP [auth 1A],
SPA [auth 1A],
SPB [auth 2A],
SPC [auth 2A],
SQ [auth 1A],
SQA [auth 1A],
SQB [auth 2A],
SQC [auth 2A],
SR [auth 1A],
SRA [auth 1A],
SRB [auth 2A],
SRC [auth 2A],
SS [auth 1A],
SSA [auth 1A],
SSB [auth 2A],
SSC [auth 2B],
ST [auth 1A],
STA [auth 1B],
STB [auth 2A],
STC [auth 2P],
SU [auth 1A],
SUA [auth 1D],
SUB [auth 2A],
SV [auth 1A],
SVA [auth 1F],
SVB [auth 2A],
SVC [auth 2a],
SW [auth 1A],
SWA [auth 1P],
SWB [auth 2A],
SWC [auth 2a],
SX [auth 1A],
SXA [auth 1U],
SXB [auth 2A],
SXC [auth 2a],
SY [auth 1A],
SYA [auth 1X],
SYB [auth 2A],
SYC [auth 2a],
SZ [auth 1A],
SZA [auth 11],
SZB [auth 2A],
SZC [auth 2a],
TAA [auth 1A],
TAB [auth 17],
TAC [auth 2A],
TAD [auth 2a],
TBA [auth 1A],
TBB [auth 1a],
TBC [auth 2A],
TBD [auth 2a],
TCA [auth 1A],
TCB [auth 1a],
TCC [auth 2A],
TCD [auth 2a],
TD [auth 1A],
TDA [auth 1A],
TDB [auth 1a],
TDC [auth 2A],
TDD [auth 2a],
TE [auth 1A],
TEA [auth 1A],
TEB [auth 1a],
TEC [auth 2A],
TED [auth 2t],
TF [auth 1A],
TFA [auth 1A],
TFB [auth 1a],
TFC [auth 2A],
TG [auth 1A],
TGA [auth 1A],
TGB [auth 1a],
TGC [auth 2A],
TH [auth 1A],
THA [auth 1A],
THB [auth 1a],
THC [auth 2A],
TI [auth 1A],
TIA [auth 1A],
TIB [auth 1a],
TIC [auth 2A],
TJ [auth 1A],
TJA [auth 1A],
TJB [auth 1l],
TJC [auth 2A],
TK [auth 1A],
TKA [auth 1A],
TKB [auth 1x],
TKC [auth 2A],
TL [auth 1A],
TLA [auth 1A],
TLB [auth 2A],
TLC [auth 2A],
TM [auth 1A],
TMA [auth 1A],
TMB [auth 2A],
TMC [auth 2A],
TN [auth 1A],
TNA [auth 1A],
TNB [auth 2A],
TNC [auth 2A],
TO [auth 1A],
TOA [auth 1A],
TOB [auth 2A],
TOC [auth 2A],
TP [auth 1A],
TPA [auth 1A],
TPB [auth 2A],
TPC [auth 2A],
TQ [auth 1A],
TQA [auth 1A],
TQB [auth 2A],
TQC [auth 2A],
TR [auth 1A],
TRA [auth 1A],
TRB [auth 2A],
TRC [auth 2A],
TS [auth 1A],
TSA [auth 1A],
TSB [auth 2A],
TSC [auth 2D],
TT [auth 1A],
TTA [auth 1B],
TTB [auth 2A],
TTC [auth 2P],
TU [auth 1A],
TUA [auth 1D],
TUB [auth 2A],
TUC [auth 25],
TV [auth 1A],
TVA [auth 1F],
TVB [auth 2A],
TVC [auth 2a],
TW [auth 1A],
TWA [auth 1P],
TWB [auth 2A],
TWC [auth 2a],
TX [auth 1A],
TXA [auth 1U],
TXB [auth 2A],
TXC [auth 2a],
TY [auth 1A],
TYA [auth 1X],
TYB [auth 2A],
TYC [auth 2a],
TZ [auth 1A],
TZA [auth 11],
TZB [auth 2A],
TZC [auth 2a],
UAA [auth 1A],
UAB [auth 17],
UAC [auth 2A],
UAD [auth 2a],
UBA [auth 1A],
UBB [auth 1a],
UBC [auth 2A],
UBD [auth 2a],
UCA [auth 1A],
UCB [auth 1a],
UCC [auth 2A],
UCD [auth 2a],
UD [auth 1A],
UDA [auth 1A],
UDB [auth 1a],
UDC [auth 2A],
UDD [auth 2a],
UE [auth 1A],
UEA [auth 1A],
UEB [auth 1a],
UEC [auth 2A],
UED [auth 2v],
UF [auth 1A],
UFA [auth 1A],
UFB [auth 1a],
UFC [auth 2A],
UG [auth 1A],
UGA [auth 1A],
UGB [auth 1a],
UGC [auth 2A],
UH [auth 1A],
UHA [auth 1A],
UHB [auth 1a],
UHC [auth 2A],
UI [auth 1A],
UIA [auth 1A],
UIB [auth 1a],
UIC [auth 2A],
UJ [auth 1A],
UJA [auth 1A],
UJB [auth 1m],
UJC [auth 2A],
UK [auth 1A],
UKA [auth 1A],
UKB [auth 1x],
UKC [auth 2A],
UL [auth 1A],
ULA [auth 1A],
ULB [auth 2A],
ULC [auth 2A],
UM [auth 1A],
UMA [auth 1A],
UMB [auth 2A],
UMC [auth 2A],
UN [auth 1A],
UNA [auth 1A],
UNB [auth 2A],
UNC [auth 2A],
UO [auth 1A],
UOA [auth 1A],
UOB [auth 2A],
UOC [auth 2A],
UP [auth 1A],
UPA [auth 1A],
UPB [auth 2A],
UPC [auth 2A],
UQ [auth 1A],
UQA [auth 1A],
UQB [auth 2A],
UQC [auth 2A],
UR [auth 1A],
URA [auth 1A],
URB [auth 2A],
URC [auth 2A],
US [auth 1A],
USA [auth 1A],
USB [auth 2A],
USC [auth 2D],
UT [auth 1A],
UTA [auth 1B],
UTB [auth 2A],
UTC [auth 2Q],
UU [auth 1A],
UUA [auth 1D],
UUB [auth 2A],
UUC [auth 25],
UV [auth 1A],
UVA [auth 1F],
UVB [auth 2A],
UVC [auth 2a],
UW [auth 1A],
UWA [auth 1P],
UWB [auth 2A],
UWC [auth 2a],
UX [auth 1A],
UXA [auth 1U],
UXB [auth 2A],
UXC [auth 2a],
UY [auth 1A],
UYA [auth 1X],
UYB [auth 2A],
UYC [auth 2a],
UZ [auth 1A],
UZA [auth 11],
UZB [auth 2A],
UZC [auth 2a],
VAA [auth 1A],
VAB [auth 17],
VAC [auth 2A],
VAD [auth 2a],
VBA [auth 1A],
VBB [auth 1a],
VBC [auth 2A],
VBD [auth 2a],
VCA [auth 1A],
VCB [auth 1a],
VCC [auth 2A],
VCD [auth 2a],
VD [auth 1A],
VDA [auth 1A],
VDB [auth 1a],
VDC [auth 2A],
VDD [auth 2a],
VE [auth 1A],
VEA [auth 1A],
VEB [auth 1a],
VEC [auth 2A],
VED [auth 2v],
VF [auth 1A],
VFA [auth 1A],
VFB [auth 1a],
VFC [auth 2A],
VG [auth 1A],
VGA [auth 1A],
VGB [auth 1a],
VGC [auth 2A],
VH [auth 1A],
VHA [auth 1A],
VHB [auth 1a],
VHC [auth 2A],
VI [auth 1A],
VIA [auth 1A],
VIB [auth 1a],
VIC [auth 2A],
VJ [auth 1A],
VJA [auth 1A],
VJB [auth 1n],
VJC [auth 2A],
VK [auth 1A],
VKA [auth 1A],
VKB [auth 1x],
VKC [auth 2A],
VL [auth 1A],
VLA [auth 1A],
VLB [auth 2A],
VLC [auth 2A],
VM [auth 1A],
VMA [auth 1A],
VMB [auth 2A],
VMC [auth 2A],
VN [auth 1A],
VNA [auth 1A],
VNB [auth 2A],
VNC [auth 2A],
VO [auth 1A],
VOA [auth 1A],
VOB [auth 2A],
VOC [auth 2A],
VP [auth 1A],
VPA [auth 1A],
VPB [auth 2A],
VPC [auth 2A],
VQ [auth 1A],
VQA [auth 1A],
VQB [auth 2A],
VQC [auth 2A],
VR [auth 1A],
VRA [auth 1A],
VRB [auth 2A],
VRC [auth 2A],
VS [auth 1A],
VSA [auth 1A],
VSB [auth 2A],
VSC [auth 2D],
VT [auth 1A],
VTA [auth 1B],
VTB [auth 2A],
VTC [auth 2Q],
VU [auth 1A],
VUA [auth 1D],
VUB [auth 2A],
VUC [auth 25],
VV [auth 1A],
VVA [auth 1F],
VVB [auth 2A],
VVC [auth 2a],
VW [auth 1A],
VWA [auth 1P],
VWB [auth 2A],
VWC [auth 2a],
VX [auth 1A],
VXA [auth 1U],
VXB [auth 2A],
VXC [auth 2a],
VYA [auth 1X],
VYB [auth 2A],
VYC [auth 2a],
VZ [auth 1A],
VZA [auth 12],
VZB [auth 2A],
VZC [auth 2a],
WAA [auth 1A],
WAB [auth 17],
WAC [auth 2A],
WAD [auth 2a],
WBA [auth 1A],
WBB [auth 1a],
WBC [auth 2A],
WBD [auth 2a],
WCA [auth 1A],
WCB [auth 1a],
WCC [auth 2A],
WCD [auth 2a],
WD [auth 1A],
WDA [auth 1A],
WDB [auth 1a],
WDC [auth 2A],
WDD [auth 2a],
WE [auth 1A],
WEA [auth 1A],
WEB [auth 1a],
WEC [auth 2A],
WED [auth 2w],
WF [auth 1A],
WFA [auth 1A],
WFB [auth 1a],
WFC [auth 2A],
WG [auth 1A],
WGA [auth 1A],
WGB [auth 1a],
WGC [auth 2A],
WH [auth 1A],
WHA [auth 1A],
WHB [auth 1a],
WHC [auth 2A],
WI [auth 1A],
WIA [auth 1A],
WIB [auth 1a],
WIC [auth 2A],
WJ [auth 1A],
WJA [auth 1A],
WJB [auth 1n],
WJC [auth 2A],
WK [auth 1A],
WKA [auth 1A],
WKB [auth 1x],
WKC [auth 2A],
WL [auth 1A],
WLA [auth 1A],
WLB [auth 2A],
WLC [auth 2A],
WM [auth 1A],
WMA [auth 1A],
WMB [auth 2A],
WMC [auth 2A],
WN [auth 1A],
WNA [auth 1A],
WNB [auth 2A],
WNC [auth 2A],
WO [auth 1A],
WOA [auth 1A],
WOB [auth 2A],
WOC [auth 2A],
WP [auth 1A],
WPA [auth 1A],
WPB [auth 2A],
WPC [auth 2A],
WQ [auth 1A],
WQA [auth 1A],
WQB [auth 2A],
WQC [auth 2A],
WR [auth 1A],
WRA [auth 1A],
WRB [auth 2A],
WRC [auth 2A],
WS [auth 1A],
WSA [auth 1A],
WSB [auth 2A],
WSC [auth 2D],
WT [auth 1A],
WTA [auth 1B],
WTB [auth 2A],
WTC [auth 2R],
WU [auth 1A],
WUA [auth 1D],
WUB [auth 2A],
WUC [auth 25],
WV [auth 1A],
WVA [auth 1F],
WVB [auth 2A],
WVC [auth 2a],
WW [auth 1A],
WWA [auth 1P],
WWB [auth 2A],
WWC [auth 2a],
WX [auth 1A],
WXA [auth 1U],
WXB [auth 2A],
WXC [auth 2a],
WY [auth 1A],
WYA [auth 1X],
WYB [auth 2A],
WYC [auth 2a],
WZ [auth 1A],
WZA [auth 12],
WZB [auth 2A],
WZC [auth 2a],
XAA [auth 1A],
XAB [auth 17],
XAC [auth 2A],
XAD [auth 2a],
XBA [auth 1A],
XBB [auth 1a],
XBC [auth 2A],
XBD [auth 2a],
XCA [auth 1A],
XCB [auth 1a],
XCC [auth 2A],
XCD [auth 2a],
XD [auth 1A],
XDA [auth 1A],
XDB [auth 1a],
XDC [auth 2A],
XDD [auth 2a],
XE [auth 1A],
XEA [auth 1A],
XEB [auth 1a],
XEC [auth 2A],
XED [auth 2w],
XF [auth 1A],
XFA [auth 1A],
XFB [auth 1a],
XFC [auth 2A],
XG [auth 1A],
XGA [auth 1A],
XGB [auth 1a],
XGC [auth 2A],
XH [auth 1A],
XHA [auth 1A],
XHB [auth 1a],
XHC [auth 2A],
XI [auth 1A],
XIA [auth 1A],
XIB [auth 1a],
XIC [auth 2A],
XJ [auth 1A],
XJA [auth 1A],
XJC [auth 2A],
XK [auth 1A],
XKA [auth 1A],
XKB [auth 1x],
XKC [auth 2A],
XL [auth 1A],
XLA [auth 1A],
XLB [auth 2A],
XLC [auth 2A],
XM [auth 1A],
XMA [auth 1A],
XMB [auth 2A],
XMC [auth 2A],
XN [auth 1A],
XNA [auth 1A],
XNB [auth 2A],
XNC [auth 2A],
XO [auth 1A],
XOA [auth 1A],
XOB [auth 2A],
XOC [auth 2A],
XP [auth 1A],
XPA [auth 1A],
XPB [auth 2A],
XPC [auth 2A],
XQ [auth 1A],
XQA [auth 1A],
XQB [auth 2A],
XQC [auth 2A],
XR [auth 1A],
XRA [auth 1A],
XRB [auth 2A],
XRC [auth 2A],
XS [auth 1A],
XSA [auth 1A],
XSB [auth 2A],
XSC [auth 2D],
XT [auth 1A],
XTA [auth 1B],
XTB [auth 2A],
XTC [auth 2R],
XU [auth 1A],
XUA [auth 1D],
XUB [auth 2A],
XV [auth 1A],
XVA [auth 1F],
XVB [auth 2A],
XVC [auth 2a],
XW [auth 1A],
XWA [auth 1Q],
XWB [auth 2A],
XWC [auth 2a],
XX [auth 1A],
XXA [auth 1U],
XXB [auth 2A],
XXC [auth 2a],
XY [auth 1A],
XYA [auth 1Y],
XYB [auth 2A],
XYC [auth 2a],
XZ [auth 1A],
XZA [auth 13],
XZB [auth 2A],
XZC [auth 2a],
YAA [auth 1A],
YAB [auth 17],
YAC [auth 2A],
YAD [auth 2a],
YBA [auth 1A],
YBB [auth 1a],
YBC [auth 2A],
YBD [auth 2a],
YCA [auth 1A],
YCB [auth 1a],
YCC [auth 2A],
YCD [auth 2a],
YD [auth 1A],
YDA [auth 1A],
YDB [auth 1a],
YDC [auth 2A],
YDD [auth 2a],
YE [auth 1A],
YEA [auth 1A],
YEB [auth 1a],
YEC [auth 2A],
YED [auth 2w],
YF [auth 1A],
YFA [auth 1A],
YFB [auth 1a],
YFC [auth 2A],
YG [auth 1A],
YGA [auth 1A],
YGB [auth 1a],
YGC [auth 2A],
YH [auth 1A],
YHA [auth 1A],
YHB [auth 1a],
YHC [auth 2A],
YI [auth 1A],
YIA [auth 1A],
YIB [auth 1a],
YIC [auth 2A],
YJ [auth 1A],
YJA [auth 1A],
YJB [auth 1p],
YJC [auth 2A],
YK [auth 1A],
YKA [auth 1A],
YKB [auth 1x],
YKC [auth 2A],
YL [auth 1A],
YLA [auth 1A],
YLB [auth 2A],
YLC [auth 2A],
YM [auth 1A],
YMA [auth 1A],
YMB [auth 2A],
YMC [auth 2A],
YN [auth 1A],
YNA [auth 1A],
YNB [auth 2A],
YNC [auth 2A],
YO [auth 1A],
YOA [auth 1A],
YOB [auth 2A],
YOC [auth 2A],
YP [auth 1A],
YPA [auth 1A],
YPB [auth 2A],
YPC [auth 2A],
YQ [auth 1A],
YQA [auth 1A],
YQB [auth 2A],
YQC [auth 2A],
YR [auth 1A],
YRA [auth 1A],
YRB [auth 2A],
YRC [auth 2A],
YS [auth 1A],
YSA [auth 1A],
YSB [auth 2A],
YSC [auth 2E],
YT [auth 1A],
YTA [auth 1B],
YTB [auth 2A],
YTC [auth 2T],
YU [auth 1A],
YUA [auth 1D],
YUB [auth 2A],
YUC [auth 26],
YV [auth 1A],
YVA [auth 1F],
YVB [auth 2A],
YVC [auth 2a],
YW [auth 1A],
YWA [auth 1Q],
YWB [auth 2A],
YWC [auth 2a],
YX [auth 1A],
YXA [auth 1U],
YXB [auth 2A],
YXC [auth 2a],
YY [auth 1A],
YYA [auth 1Y],
YYB [auth 2A],
YYC [auth 2a],
YZ [auth 1A],
YZA [auth 13],
YZB [auth 2A],
YZC [auth 2a],
ZAA [auth 1A],
ZAB [auth 17],
ZAC [auth 2A],
ZAD [auth 2a],
ZBA [auth 1A],
ZBB [auth 1a],
ZBC [auth 2A],
ZBD [auth 2a],
ZCA [auth 1A],
ZCB [auth 1a],
ZCC [auth 2A],
ZCD [auth 2a],
ZD [auth 1A],
ZDA [auth 1A],
ZDB [auth 1a],
ZDC [auth 2A],
ZDD [auth 2a],
ZE [auth 1A],
ZEA [auth 1A],
ZEB [auth 1a],
ZEC [auth 2A],
ZED [auth 2w],
ZF [auth 1A],
ZFA [auth 1A],
ZFB [auth 1a],
ZFC [auth 2A],
ZG [auth 1A],
ZGA [auth 1A],
ZGB [auth 1a],
ZGC [auth 2A],
ZH [auth 1A],
ZHA [auth 1A],
ZHB [auth 1a],
ZHC [auth 2A],
ZI [auth 1A],
ZIA [auth 1A],
ZIB [auth 1a],
ZIC [auth 2A],
ZJ [auth 1A],
ZJA [auth 1A],
ZJB [auth 1t],
ZJC [auth 2A],
ZK [auth 1A],
ZKA [auth 1A],
ZKB [auth 1x],
ZKC [auth 2A],
ZL [auth 1A],
ZLA [auth 1A],
ZLB [auth 2A],
ZLC [auth 2A],
ZM [auth 1A],
ZMA [auth 1A],
ZMB [auth 2A],
ZMC [auth 2A],
ZN [auth 1A],
ZNA [auth 1A],
ZNB [auth 2A],
ZNC [auth 2A],
ZO [auth 1A],
ZOA [auth 1A],
ZOB [auth 2A],
ZOC [auth 2A],
ZP [auth 1A],
ZPA [auth 1A],
ZPB [auth 2A],
ZPC [auth 2A],
ZQ [auth 1A],
ZQA [auth 1A],
ZQB [auth 2A],
ZQC [auth 2A],
ZR [auth 1A],
ZRA [auth 1A],
ZRB [auth 2A],
ZS [auth 1A],
ZSA [auth 1A],
ZSB [auth 2A],
ZSC [auth 2E],
ZT [auth 1A],
ZTA [auth 1B],
ZTB [auth 2A],
ZTC [auth 2T],
ZU [auth 1A],
ZUA [auth 1E],
ZUB [auth 2A],
ZV [auth 1A],
ZVA [auth 1F],
ZVB [auth 2A],
ZVC [auth 2a],
ZW [auth 1A],
ZWA [auth 1Q],
ZWB [auth 2A],
ZWC [auth 2a],
ZX [auth 1A],
ZXA [auth 1U],
ZXB [auth 2A],
ZXC [auth 2a],
ZY [auth 1A],
ZYA [auth 1Y],
ZYB [auth 2A],
ZYC [auth 2a],
ZZ [auth 1A],
ZZA [auth 13],
ZZB [auth 2A],
ZZC [auth 2a]
MAGNESIUM ION
Mg
JLVVSXFLKOJNIY-UHFFFAOYSA-N
Modified Residues  1 Unique
IDChains TypeFormula2D DiagramParent
0TD
Query on 0TD		QA [auth 1l],
UC [auth 2l]		L-PEPTIDE LINKINGC5 H9 N O4 SASP
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.60 Å
  • R-Value Free: 0.298 
  • R-Value Work: 0.241 
  • R-Value Observed: 0.244 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 208.8α = 90
b = 444.65β = 90
c = 619.33γ = 90
Software Package:
Software NamePurpose
PHENIXrefinement
XDSdata reduction
XSCALEdata scaling
PHASERphasing
Cootmodel building
PDB_EXTRACTdata extraction

Structure Validation

View Full Validation Report



Ligand Structure Quality Assessment 


View more in-depth experimental data
Entry History & Funding Information

Deposition Data

Funding OrganizationLocationGrant Number
Other governmentUnited StatesUniversity of Illinois Startup Funds
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)United StatesR21-AI137584
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesR01-GM132302
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)United StatesR35-GM127134
Other privateUnited StatesLEO Foundation grant LF18006
Other privateUnited StatesBlavatnik Biomedical Accelerator at Harvard University

Revision History  (Full details and data files)

  • Version 1.0: 2021-10-13
    Type: Initial release
  • Version 1.1: 2022-04-27
    Changes: Database references
  • Version 1.2: 2023-10-18
    Changes: Data collection, Refinement description
  • Version 1.3: 2023-11-15
    Changes: Data collection