Download MendeleyKRAS4b WT 1-185 bound to GDP-Mg2+
Betts, L., Rossman, K.L.To be published.
8ECR
KRAS4b WT 1-185 bound to GDP-Mg2+
- PDB DOI: https://doi.org/10.2210/pdb8ECR/pdb
- Classification: HYDROLASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2022-09-02 Released: 2023-09-06
- Funding Organization(s): National Institutes of Health/National Cancer Institute (NIH/NCI)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.42 Å
- R-Value Free: 0.169
- R-Value Work: 0.147
- R-Value Observed: 0.165
This is version 2.1 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| GTPase KRas | 185 | Homo sapiens | Mutation(s): 1 Gene Names: KRAS, KRAS2, RASK2 EC: 3.6.5.2 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P01116 (Homo sapiens) Explore P01116 Go to UniProtKB: P01116 | |||||
PHAROS: P01116 GTEx: ENSG00000133703 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P01116 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GDP (Subject of Investigation/LOI) Query on GDP | D [auth A], G [auth B] | GUANOSINE-5'-DIPHOSPHATE C10 H15 N5 O11 P2 QGWNDRXFNXRZMB-UUOKFMHZSA-N |  | ||
| GOL Query on GOL | E [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| MG (Subject of Investigation/LOI) Query on MG | C [auth A], F [auth B] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.42 Å
- R-Value Free: 0.169
- R-Value Work: 0.147
- R-Value Observed: 0.165
- Space Group: P 3
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 84.313 | α = 90 |
| b = 84.313 | β = 90 |
| c = 41.733 | γ = 120 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| XDS | data scaling |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2023-09-06 Deposition Author(s): Betts, L., Rossman, K.L.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Cancer Institute (NIH/NCI) | United States | 5R01CA223495 |
Revision History (Full details and data files)
- Version 1.0: 2023-09-06
Type: Initial release - Version 2.0: 2023-09-20
Changes: Advisory, Author supporting evidence, Database references, Polymer sequence, Source and taxonomy, Structure summary - Version 2.1: 2023-09-27
Changes: Database references
