8QNS

Crystal structure of murine AIF bound to N-terminal domain of CHCHD4

PDB DOI: https://doi.org/10.2210/pdb8QNS/pdb

Classification: PROTEIN BINDING
Organism(s): Mus musculus
Expression System: Escherichia coli
Mutation(s): No

Deposited: 2023-09-27 Released: 2024-05-08
Deposition Author(s): Fagnani, E., Milani, M.
Funding Organization(s): European Union (EU)

Experimental Data Snapshot

Method: X-RAY DIFFRACTION
Resolution: 3.21 Å
R-Value Free: 0.284
R-Value Work: 0.233

Starting Model: experimental
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wwPDB Validation 3D Report Full Report

Ligand Structure Quality Assessment

This is version 1.0 of the entry. See complete history.

Literature

Structural characterization of the interaction between apoptosis inducing factor (AIF) and CHCHD4.

Fagnani, E., Milani, M.

To be published.

Macromolecule Content

Total Structure Weight: 247.05 kDa
Atom Count: 14,701
Modelled Residue Count: 1,832
Deposited Residue Count: 2,204
Unique protein chains: 2

Macromolecules

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(by identity cutoff) | 3D Structure

Entity ID: 1
Molecule	Chains	Sequence Length	Organism	Details	Image
Apoptosis-inducing factor 1, mitochondrial	A, B [auth D], C [auth G], D [auth J]	524	Mus musculus	Mutation(s): 0 Gene Names: Aifm1, Aif, Pdcd8 EC: 1.6.99
UniProt
Find proteins for Q9Z0X1 (Mus musculus) Explore Q9Z0X1 Go to UniProtKB: Q9Z0X1
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q9Z0X1
Sequence Annotations Expand
Reference Sequence

Find similar proteins by:

(by identity cutoff) | 3D Structure

Entity ID: 2
Molecule	Chains	Sequence Length	Organism	Details	Image
Mitochondrial intermembrane space import and assembly protein 40	E [auth M], F [auth N], G [auth O], H [auth P]	27	Mus musculus	Mutation(s): 0
UniProt
Find proteins for Q8VEA4 (Mus musculus) Explore Q8VEA4 Go to UniProtKB: Q8VEA4
Entity Groups
Sequence Clusters	30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt Group	Q8VEA4
Sequence Annotations Expand
Reference Sequence

Small Molecules

Ligands 2 Unique
ID	Chains	Name / Formula / InChI Key	2D Diagram	3D Interactions
FAD Query on FAD Download Ideal Coordinates CCD File SDF format, chain I [auth A] SDF format, chain K [auth D] SDF format, chain M [auth G] SDF format, chain O [auth J] MOL2 format, chain I [auth A] MOL2 format, chain K [auth D] MOL2 format, chain M [auth G] MOL2 format, chain O [auth J] mmCIF format, chain I [auth A] mmCIF format, chain K [auth D] mmCIF format, chain M [auth G] mmCIF format, chain O [auth J]	I [auth A], K [auth D], M [auth G], O [auth J]	FLAVIN-ADENINE DINUCLEOTIDE C₂₇ H₃₃ N₉ O₁₅ P₂ VWWQXMAJTJZDQX-UYBVJOGSSA-N		Interactions Focus chain I [auth A] Focus chain K [auth D] Focus chain M [auth G] Focus chain O [auth J] Interactions & Density Focus chain I [auth A] Focus chain K [auth D] Focus chain M [auth G] Focus chain O [auth J]
NAD (Subject of Investigation/LOI) Query on NAD Download Ideal Coordinates CCD File SDF format, chain L [auth D] SDF format, chain J [auth A] SDF format, chain N [auth G] SDF format, chain P [auth J] MOL2 format, chain L [auth D] MOL2 format, chain J [auth A] MOL2 format, chain N [auth G] MOL2 format, chain P [auth J] mmCIF format, chain L [auth D] mmCIF format, chain J [auth A] mmCIF format, chain N [auth G] mmCIF format, chain P [auth J]	J [auth A], L [auth D], N [auth G], P [auth J]	NICOTINAMIDE-ADENINE-DINUCLEOTIDE C₂₁ H₂₇ N₇ O₁₄ P₂ BAWFJGJZGIEFAR-NNYOXOHSSA-N		Interactions Focus chain J [auth A] Focus chain L [auth D] Focus chain N [auth G] Focus chain P [auth J] Interactions & Density Focus chain J [auth A] Focus chain L [auth D] Focus chain N [auth G] Focus chain P [auth J]