Download MendeleyCrystal Structure of modified HIV reverse transcriptase p51 domain (FPC1) with picric acid and xanthene bound
Pedersen, L.C., London, R.E.To be published.
8TCM
Crystal Structure of modified HIV reverse transcriptase p51 domain (FPC1) with picric acid and Xanthene-1,3,6,8-tetrol bound
- PDB DOI: https://doi.org/10.2210/pdb8TCM/pdb
- Classification: DNA BINDING PROTEIN
- Organism(s): HIV whole-genome vector AA1305#18
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2023-07-02 Released: 2024-07-17
- Funding Organization(s): National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.82 Å
- R-Value Free: 0.223
- R-Value Work: 0.194
- R-Value Observed: 0.195
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| p51 subunit | A [auth B] | 343 | HIV whole-genome vector AA1305#18 | Mutation(s): 0 |  |
UniProt | |||||
Find proteins for P04585 (Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)) Explore P04585 Go to UniProtKB: P04585 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P04585 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ZQT (Subject of Investigation/LOI) Query on ZQT | E [auth B], F [auth B] | 9H-xanthene-1,3,6,8-tetrol C13 H10 O5 WRWDLBILCDUPOS-UHFFFAOYSA-N |  | ||
| TNF (Subject of Investigation/LOI) Query on TNF | B, C [auth B], D [auth B] | PICRIC ACID C6 H3 N3 O7 OXNIZHLAWKMVMX-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.82 Å
- R-Value Free: 0.223
- R-Value Work: 0.194
- R-Value Observed: 0.195
- Space Group: I 2 2 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 77.309 | α = 90 |
| b = 99.406 | β = 90 |
| c = 104.747 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| PHENIX | refinement |
| HKL-3000 | data reduction |
| HKL-3000 | data scaling |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-07-17 Deposition Author(s): Pedersen, L.C., London, R.E.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS) | United States | ZIA-ES050111 |
| National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS) | United States | ZIC-ES102645 |
Revision History (Full details and data files)
- Version 1.0: 2024-07-17
Type: Initial release
