Human DNA polymerase eta-DNA-araC-ended primer-dAMPNPP ternary complex with Mg2+
Chang, C., Gao, Y.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
DNA polymerase eta | 435 | Homo sapiens | Mutation(s): 0  Gene Names: POLH, RAD30, RAD30A, XPV EC: 2.7.7.7 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9Y253 (Homo sapiens) Explore Q9Y253  Go to UniProtKB:  Q9Y253 | |||||
PHAROS:  Q9Y253 GTEx:  ENSG00000170734  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q9Y253 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
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Molecule | Chains | Length | Organism | Image | |
DNA (5'-D(*CP*AP*TP*TP*GP*TP*GP*AP*CP*GP*CP*T)-3') | B [auth T] | 12 | synthetic construct | ||
Sequence AnnotationsExpand | |||||
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Find similar nucleic acids by: Sequence | 3D Structure
Entity ID: 3 | |||||
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Molecule | Chains | Length | Organism | Image | |
DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*C)-3') | C [auth P] | 8 | synthetic construct | ||
Sequence AnnotationsExpand | |||||
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Ligands 3 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
DZ4 Query on DZ4 | F [auth A] | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine C10 H17 N6 O11 P3 WKIPJDSLGCBQCU-RRKCRQDMSA-N | |||
GOL Query on GOL | G [auth A], H [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N | |||
MG Query on MG | D [auth A], E [auth A] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |
Length ( Å ) | Angle ( ˚ ) |
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a = 98.759 | α = 90 |
b = 98.759 | β = 90 |
c = 81.97 | γ = 120 |
Software Name | Purpose |
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PHENIX | refinement |
XSCALE | data scaling |
PDB_EXTRACT | data extraction |
XDS | data reduction |
MOLREP | phasing |
Funding Organization | Location | Grant Number |
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Cancer Prevention and Research Institute of Texas (CPRIT) | United States | RR190046 |
Welch Foundation | United States | C-2033-20200401 |
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | T32 GM008280 |