Download MendeleyHuman eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol
Bhatt, G.B., Naineni, S.K., Nagar, B.N.To be published.
9AVR
Human eIF4A-1 in complex with AMP-PNP, RNA, and the inhibitor silvestrol
- PDB DOI: https://doi.org/10.2210/pdb9AVR/pdb
- NAKB: 9AVR
- Classification: RNA BINDING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2024-03-04 Released: 2024-10-23
- Funding Organization(s): Canadian Institutes of Health Research (CIHR)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.91 Å
- R-Value Free: 0.197
- R-Value Work: 0.147
- R-Value Observed: 0.152
Starting Model: in silico
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Eukaryotic initiation factor 4A-I | 406 | Homo sapiens | Mutation(s): 0 Gene Names: EIF4A1, DDX2A, EIF4A EC: 3.6.4.13 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P60842 (Homo sapiens) Explore P60842 Go to UniProtKB: P60842 | |||||
PHAROS: P60842 GTEx: ENSG00000161960 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P60842 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar nucleic acids by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Length | Organism | Image | |
| RNA oligonucleotide (AG)5 | 10 | Homo sapiens |  | ||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 4 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| A1AG8 (Subject of Investigation/LOI) Query on A1AG8 | G [auth B] | silvestrol C34 H38 O13 GVKXFVCXBFGBCD-QKDMMWSPSA-N |  | ||
| ANP (Subject of Investigation/LOI) Query on ANP | C [auth A] | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER C10 H17 N6 O12 P3 PVKSNHVPLWYQGJ-KQYNXXCUSA-N |  | ||
| IOD Query on IOD | E [auth A], F [auth A] | IODIDE ION I XMBWDFGMSWQBCA-UHFFFAOYSA-M |  | ||
| MG Query on MG | D [auth A] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.91 Å
- R-Value Free: 0.197
- R-Value Work: 0.147
- R-Value Observed: 0.152
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 58.48 | α = 90 |
| b = 84.295 | β = 90 |
| c = 88.412 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data scaling |
| PHASER | phasing |
| HKL-2000 | data reduction |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-10-23 Deposition Author(s): Bhatt, G.B., Naineni, S.K., Cencic, R.C., Jiramongkolsiri, E.J., Huang, S.H., Pelletier, J.P., Nagar, B.N.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Canadian Institutes of Health Research (CIHR) | Canada | -- |
Revision History (Full details and data files)
- Version 1.0: 2024-10-23
Type: Initial release
