4CLJ

Structure of L1196M Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile).

Changes made to a PDB entry after its initial release are considered to be either “major” or “minor”. The latest minor version of each major version is available as a file download. More information about the PDB versioning is available.

Version Number	Version Date	Version Type/Reason	Version Change	Revised CIF Category
1.0	2014-05-28	Initial release
1.1	2014-06-04		Database references
1.2	2014-09-17		Atomic model, Derived calculations, Non-polymer description
1.3	2019-05-08		Data collection, Experimental preparation, Other	database_PDB_rev, database_PDB_rev_record, exptl_crystal_grow, pdbx_database_proc, pdbx_database_status
1.4	2023-12-20		Data collection, Database references, Derived calculations, Other, Refinement description	chem_comp_atom, chem_comp_bond, database_2, pdbx_database_status, pdbx_initial_refinement_model, software, struct_site	Download

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.