1AOR

STRUCTURE OF A HYPERTHERMOPHILIC TUNGSTOPTERIN ENZYME, ALDEHYDE FERREDOXIN OXIDOREDUCTASE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1aorb1	All alpha proteins	Aldehyde ferredoxin oxidoreductase, C-terminal domains	Aldehyde ferredoxin oxidoreductase, C-terminal domains	Aldehyde ferredoxin oxidoreductase, C-terminal domains	Aldehyde ferredoxin oxidoreductase	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
B	d1aorb2	Alpha and beta proteins (a+b)	Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
A	d1aora1	All alpha proteins	Aldehyde ferredoxin oxidoreductase, C-terminal domains	Aldehyde ferredoxin oxidoreductase, C-terminal domains	Aldehyde ferredoxin oxidoreductase, C-terminal domains	Aldehyde ferredoxin oxidoreductase	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
A	d1aora2	Alpha and beta proteins (a+b)	Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Aldehyde ferredoxin oxidoreductase, N-terminal domain	8036737	3000972	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Aldehyde ferredoxin oxidoreductase, C-terminal domains	8038483	3001102	SCOP2B (2022-06-29)
A	SCOP2 Family	Aldehyde ferredoxin oxidoreductase, N-terminal domain	8024358	4002226	SCOP2 (2022-06-29)
A	SCOP2 Family	Aldehyde ferredoxin oxidoreductase, C-terminal domains	8026104	4001221	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aldehyde ferredoxin oxidoreductase, N-terminal domain	8036737	3000972	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aldehyde ferredoxin oxidoreductase, C-terminal domains	8038483	3001102	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	AFOR_C	e1aorB1	A: alpha complex topology	X: Aldehyde ferredoxin oxidoreductase-C (From Topology)	H: Aldehyde ferredoxin oxidoreductase-C (From Topology)	T: Aldehyde ferredoxin oxidoreductase-C	F: AFOR_C	ECOD (1.6)
B	AFOR_N	e1aorB2	A: a+b four layers	X: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	H: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	T: Aldehyde ferredoxin oxidoreductase, N-terminal domain	F: AFOR_N	ECOD (1.6)
A	AFOR_C	e1aorA1	A: alpha complex topology	X: Aldehyde ferredoxin oxidoreductase-C (From Topology)	H: Aldehyde ferredoxin oxidoreductase-C (From Topology)	T: Aldehyde ferredoxin oxidoreductase-C	F: AFOR_C	ECOD (1.6)
A	AFOR_N	e1aorA2	A: a+b four layers	X: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	H: Aldehyde ferredoxin oxidoreductase, N-terminal domain (From Topology)	T: Aldehyde ferredoxin oxidoreductase, N-terminal domain	F: AFOR_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.60.9.10	Alpha Beta	4-Layer Sandwich	Aldehyde Ferredoxin Oxidoreductase	A, domain 1	CATH (4.3.0)
B	1.10.569.10	Mainly Alpha	Orthogonal Bundle	Aldehyde Ferredoxin Oxidoreductase Protein, subunit A	domain 2	CATH (4.3.0)
B	1.10.599.10	Mainly Alpha	Orthogonal Bundle	Aldehyde Ferredoxin Oxidoreductase Protein, subunit A	domain 3	CATH (4.3.0)
A	3.60.9.10	Alpha Beta	4-Layer Sandwich	Aldehyde Ferredoxin Oxidoreductase	A, domain 1	CATH (4.3.0)
A	1.10.569.10	Mainly Alpha	Orthogonal Bundle	Aldehyde Ferredoxin Oxidoreductase Protein, subunit A	domain 2	CATH (4.3.0)
A	1.10.599.10	Mainly Alpha	Orthogonal Bundle	Aldehyde Ferredoxin Oxidoreductase Protein, subunit A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02730	Aldehyde ferredoxin oxidoreductase, N-terminal domain (AFOR_N)	Aldehyde ferredoxin oxidoreductase, N-terminal domain	Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This domain interacts with the tungsten cofactor [1].	Domain
A, B	PF01314	Aldehyde ferredoxin oxidoreductase, domains 2 & 3 (AFOR_C)	Aldehyde ferredoxin oxidoreductase, domains 2 & 3	Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This family is composed of two structural domains t ...	Aldehyde ferredoxin oxidoreductase (AOR) catalyses the reversible oxidation of aldehydes to their corresponding carboxylic acids with their accompanying reduction of the redox protein ferredoxin. This family is composed of two structural domains that bind the tungsten cofactor via DXXGL(C/D) motifs. In addition to maintaining specific binding interactions with the cofactor, another role for domains 2 and 3 may be to regulate substrate access to AOR [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ALDEHYDE FERREDOXIN OXIDOREDUCTASE	aldehyde ferredoxin oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding electron transfer activity cation binding ion binding metal ion binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013985	Aldehyde ferredoxin oxidoreductase, domain 3	Homologous Superfamily
A, B	IPR036503	Aldehyde ferredoxin oxidoreductase, N-terminal domain superfamily	Homologous Superfamily
A, B	IPR001203	Aldehyde ferredoxin oxidoreductase, C-terminal	Domain
A, B	IPR013983	Aldehyde ferredoxin oxidoreductase, N-terminal	Domain
A, B	IPR013984	Aldehyde ferredoxin oxidoreductase, domain 2	Homologous Superfamily
A, B	IPR051919	Tungsten-dependent aldehyde:ferredoxin oxidoreductase	Family
A, B	IPR036021	Aldehyde ferredoxin oxidoreductase-like, C-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.