Annotations: 1AOS

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1aosa_	All alpha proteins	L-aspartase-like	L-aspartase-like	L-aspartase/fumarase	Argininosuccinate lyase/delta-crystallin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1aosb_	All alpha proteins	L-aspartase-like	L-aspartase-like	L-aspartase/fumarase	Argininosuccinate lyase/delta-crystallin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	L-aspartase-like	8037834	3001572	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	L-aspartase-like	8037834	3001572	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lyase_1_N	e1aosA3	A: alpha arrays	X: L-aspartase N-terminal domain-like (From Topology)	H: L-aspartase N-terminal domain-like (From Topology)	T: L-aspartase N-terminal domain-like	F: Lyase_1_N	ECOD (1.6)
A	ASL_C2	e1aosA2	A: alpha arrays	X: L-aspartase C-terminal domain-like (From Homology)	H: L-aspartase C-terminal domain-like	T: L-aspartase C-terminal domain-like	F: ASL_C2	ECOD (1.6)
A	Lyase_1_C	e1aosA4	A: alpha arrays	X: L-aspartase middle domain-like	H: L-aspartase middle domain-like (From Topology)	T: L-aspartase middle domain-like	F: Lyase_1_C	ECOD (1.6)
B	Lyase_1_N	e1aosB3	A: alpha arrays	X: L-aspartase N-terminal domain-like (From Topology)	H: L-aspartase N-terminal domain-like (From Topology)	T: L-aspartase N-terminal domain-like	F: Lyase_1_N	ECOD (1.6)
B	ASL_C2	e1aosB2	A: alpha arrays	X: L-aspartase C-terminal domain-like (From Homology)	H: L-aspartase C-terminal domain-like	T: L-aspartase C-terminal domain-like	F: ASL_C2	ECOD (1.6)
B	Lyase_1_C	e1aosB4	A: alpha arrays	X: L-aspartase middle domain-like	H: L-aspartase middle domain-like (From Topology)	T: L-aspartase middle domain-like	F: Lyase_1_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF14698	Argininosuccinate lyase C-terminal (ASL_C2)	Argininosuccinate lyase C-terminal	This domain is found at the C-terminus of argininosuccinate lyase [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ARGININOSUCCINATE LYASE	amidine-lyase activity argininosuccinate lyase activity lyase activity catalytic activity carbon-nitrogen lyase activity identical protein binding protein binding binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process L-arginine biosynthetic process oxoacid metabolic process glutamine family amino acid biosynthetic process cellular biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process glutamine family amino acid metabolic process arginine metabolic process small molecule metabolic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process L-amino acid biosynthetic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process proteinogenic amino acid biosynthetic process cellular process alpha-amino acid biosynthetic process behavior multicellular organismal process locomotory behavior response to nutrient levels response to stimulus homeostatic process glutamate metabolic process intracellular nitrogen homeostasis intracellular chemical homeostasis glutamine metabolic process dicarboxylic acid metabolic process nitrogen utilization cellular homeostasis chemical homeostasis ammonia assimilation cycle ornithine metabolic process arginine biosynthetic process via ornithine non-proteinogenic amino acid metabolic process developmental process multicellular organism development anatomical structure development post-embryonic development nitrogen cycle metabolic process urea cycle amide biosynthetic process amide metabolic process urea metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000362	Fumarate lyase family	Family
A, B	IPR022761	Fumarate lyase, N-terminal	Domain
A, B	IPR024083	Fumarase/histidase, N-terminal	Homologous Superfamily
A, B	IPR008948	L-Aspartase-like	Homologous Superfamily
A, B	IPR029419	Argininosuccinate lyase, C-terminal	Domain
A, B	IPR009049	Argininosuccinate lyase	Family
A, B	IPR020557	Fumarate lyase, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P04424	argininosuccinic aciduria intellectual disability Hyperammonemia inborn errors of metabolism urea cycle disorder

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.