1BKF

FK506 BINDING PROTEIN FKBP MUTANT R42K/H87V COMPLEX WITH IMMUNOSUPPRESSANT FK506

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1bkfa_	Alpha and beta proteins (a+b)	FKBP-like	FKBP-like	FKBP immunophilin/proline isomerase	FK-506 binding protein (FKBP12), an immunophilin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Rotamase-like	8035974	3000622	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FKBP_C	e1bkfA1	A: a+b two layers	X: FKBP-like	H: FKBP-like	T: FKBP-like	F: FKBP_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.50.40	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00254	FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)	FKBP-type peptidyl-prolyl cis-trans isomerase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	FK506 BINDING PROTEIN	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding FK506 binding amide binding organic cyclic compound binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding FK506 binding amide binding organic cyclic compound binding macrolide binding activin receptor binding receptor serine/threonine kinase binding transmembrane receptor protein serine/threonine kinase binding transmembrane transporter binding SMAD binding I-SMAD binding channel regulator activity molecular function regulator activity transporter regulator activity molecular function inhibitor activity signaling receptor inhibitor activity signaling receptor regulator activity	protein refolding cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process cellular response to stimulus protein refolding cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling activin receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process negative regulation of cell communication negative regulation of activin receptor signaling pathway negative regulation of cellular process enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction transforming growth factor beta receptor superfamily signaling pathway regulation of activin receptor signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway cellular component organization cellular component organization or biogenesis supramolecular fiber organization amyloid fibril formation regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization intracellular calcium ion homeostasis calcium ion transport localization monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization regulation of cation channel activity inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of molecular function regulation of transmembrane transport chemical homeostasis cellular localization inorganic ion homeostasis transport homeostatic process monoatomic ion transmembrane transport regulation of transmembrane transporter activity calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport maintenance of location in cell regulation of transporter activity regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion regulation of monoatomic ion transmembrane transporter activity calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion regulation of ryanodine-sensitive calcium-release channel activity cellular homeostasis regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport macromolecule modification peptidyl-amino acid modification peptidyl-proline modification protein modification process protein peptidyl-prolyl isomerization amyloid precursor protein catabolic process regulation of protein metabolic process regulation of amyloid precursor protein catabolic process regulation of macromolecule metabolic process regulation of primary metabolic process amyloid precursor protein metabolic process regulation of metabolic process immune response immune system process regulation of immune response regulation of immune system process developmental process heart development multicellular organismal process cardiac chamber morphogenesis heart trabecula formation animal organ development heart morphogenesis circulatory system development anatomical structure morphogenesis multicellular organism development anatomical structure development anatomical structure formation involved in morphogenesis cardiac chamber development animal organ morphogenesis heart trabecula morphogenesis trabecula formation trabecula morphogenesis system development T cell activation cell activation lymphocyte activation leukocyte activation negative regulation of transforming growth factor beta receptor signaling pathway cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor protein localization regulation of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein maturation by protein folding 'de novo' protein folding system process regulation of system process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum multicellular organismal movement regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion regulation of skeletal muscle contraction by calcium ion signaling release of sequestered calcium ion into cytosol by endoplasmic reticulum skeletal muscle contraction muscle contraction regulation of striated muscle contraction regulation of muscle contraction calcium-mediated signaling striated muscle contraction musculoskeletal movement regulation of skeletal muscle contraction regulation of multicellular organismal process nervous system process neuromuscular process muscle system process regulation of muscle system process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ventricular cardiac muscle tissue morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development muscle tissue development muscle organ development cardiac muscle tissue development tissue development muscle tissue morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis regulation of protein binding positive regulation of molecular function positive regulation of protein binding regulation of binding positive regulation of binding	membrane-bounded organelle intracellular anatomical structure organelle subcompartment cellular anatomical entity intracellular membrane-bounded organelle endomembrane system sarcoplasm intracellular organelle endoplasmic reticulum subcompartment terminal cisterna organelle endoplasmic reticulum sarcoplasmic reticulum cytoplasm membrane-bounded organelle intracellular anatomical structure organelle subcompartment cellular anatomical entity intracellular membrane-bounded organelle endomembrane system sarcoplasm intracellular organelle endoplasmic reticulum subcompartment terminal cisterna organelle endoplasmic reticulum sarcoplasmic reticulum cytoplasm membrane Z disc sarcomere I band intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle bounding membrane of organelle nuclear outer membrane-endoplasmic reticulum membrane network sarcoplasmic reticulum membrane organelle membrane endoplasmic reticulum membrane cytoplasmic side of membrane side of membrane cytosol protein-containing complex membrane protein complex ryanodine receptor complex transporter complex cell periphery endoplasmic reticulum protein-containing complex plasma membrane protein complex voltage-gated calcium channel complex plasma membrane cation channel complex transmembrane transporter complex calcium channel complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
A	IPR050689	FKBP-type Peptidyl-prolyl cis-trans Isomerase	Family
A	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P62942	esophageal squamous cell carcinoma Liver Cirrhosis, Experimental medulloblastoma Pick disease renal cell carcinoma astrocytic tumor breast carcinoma lymphangioma malignant mesothelioma osteosarcoma atopic eczema tuberculosis cystic fibrosis glioblastoma kidney angiomyolipoma esophageal squamous cell carcinoma Liver Cirrhosis, Experimental medulloblastoma Pick disease renal cell carcinoma astrocytic tumor breast carcinoma lymphangioma malignant mesothelioma osteosarcoma atopic eczema tuberculosis cystic fibrosis glioblastoma kidney angiomyolipoma lung lymphangioleiomyomatosis mantle cell lymphoma psoriasis bipolar disorder tuberous sclerosis disappearing bone disease malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.