Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCobalamin (vitamin B12)-binding domain 8044100 3001260 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyCobalamin (vitamin B12)-binding domain 8044100 3001260 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCobalamin (vitamin B12)-dependent enzymes 8043856 3000609 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyCobalamin (vitamin B12)-dependent enzymes 8043856 3000609 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AB12-bindinge1cb7A1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: CheY-likeF: B12-bindingECOD (1.6)
CB12-bindinge1cb7C1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: CheY-likeF: B12-bindingECOD (1.6)
BMet_asp_mut_Ee1cb7B1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Met_asp_mut_EECOD (1.6)
DMet_asp_mut_Ee1cb7D1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Met_asp_mut_EECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF02310B12 binding domain (B12-binding)B12 binding domainThis domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, ...This domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding [2].
Domain
B, D
PF06368Methylaspartate mutase E chain (MutE) (Met_asp_mut_E)Methylaspartate mutase E chain (MutE)- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
PROTEIN (GLUTAMATE MUTASE) -
B, D
PROTEIN (GLUTAMATE MUTASE) -

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
A, B
methylaspartate mutase  M-CSA #63

This vitamin B12 dependent enzyme catalyses the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). It is involved in the subpathway that synthesises acetate and pyruvate from L-glutamate.

Defined by 4 residues: ASP:A-14HIS:A-16ARG:B-100GLU:B-171
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