Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyConcanavalin A-like lectins/glucanases 8037151 3000120 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyConcanavalin A-like lectins/glucanases 8037151 3000120 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AGlyco_hydro_7e1celA1 A: beta sandwichesX: jelly-rollH: Concanavalin A-likeT: Concanavalin A-like lectins/glucanasesF: Glyco_hydro_7ECOD (1.6)
BGlyco_hydro_7e1celB1 A: beta sandwichesX: jelly-rollH: Concanavalin A-likeT: Concanavalin A-like lectins/glucanasesF: Glyco_hydro_7ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.70.100.10 Mainly Beta Distorted Sandwich 1,4-Beta-D-Glucan Cellobiohydrolase I Chain ACATH (4.3.0)
B2.70.100.10 Mainly Beta Distorted Sandwich 1,4-Beta-D-Glucan Cellobiohydrolase I Chain ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00840Glycosyl hydrolase family 7 (Glyco_hydro_7)Glycosyl hydrolase family 7- Domain

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A, B
PCA Parent Component: GLN

RESIDAA0031

PSI-MOD :  2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
cellulose 1,4-beta-cellobiosidase (non-reducing end)  M-CSA #444

Cellobiohydrolase enzymes depolymerise cellulose into its fundamental repeating unit of two glucose molecules (cellobiose). These enzymes are key components of fungal cellulase multienzyme systems; together with randomly-acting endo-1,4-beta-glucanases (which cut internal beta-1,4-glucosidic bonds) they hydrolyse cellulose via a processive mechanism, forming cellobiose as a major product. Cellobiose is then converted by beta-glucosidases to glucose; the latter product may further be fermented to ethanol or other liquid fuels and chemicals.

These enzymes suffer from inhibition by this product, which lingers in the enzymes’ active sites and thus delays their catalytic cycles. Cellobiose accumulates over the course of the reaction unless removed by an enzyme such as beta-glucosidase, which cleaves cellobiose yielding two glucose molecules.

This entry represents the Glycoside hydrolase, family 7 (GH7).

Defined by 4 residues: GLU:A-212ASP:A-214GLU:A-217HIS:A-228
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