1CF1

ARRESTIN FROM BOVINE ROD OUTER SEGMENTS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1cf1a1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	Arrestin/Vps26-like	Arrestin	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d1cf1c1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	Arrestin/Vps26-like	Arrestin	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d1cf1d1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	Arrestin/Vps26-like	Arrestin	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1cf1b1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	Arrestin/Vps26-like	Arrestin	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Arrestin-like	8055048	4007521	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Arrestin/Vps26-like	8055049	3002071	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Arrestin/Vps26-like	8055049	3002071	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Arrestin/Vps26-like	8055049	3002071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Arrestin/Vps26-like	8055049	3002071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Arrestin_C	e1cf1A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Arrestin_C	ECOD (1.6)
A	Arrestin_N	e1cf1A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Arrestin_N	ECOD (1.6)
C	Arrestin_C	e1cf1C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Arrestin_C	ECOD (1.6)
C	Arrestin_N	e1cf1C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Arrestin_N	ECOD (1.6)
D	Arrestin_C	e1cf1D2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Arrestin_C	ECOD (1.6)
D	Arrestin_N	e1cf1D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Arrestin_N	ECOD (1.6)
B	Arrestin_C	e1cf1B2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Arrestin_C	ECOD (1.6)
B	Arrestin_N	e1cf1B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Arrestin_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.840	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
A	2.60.40.640	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
C	2.60.40.840	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
C	2.60.40.640	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
D	2.60.40.840	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
D	2.60.40.640	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
B	2.60.40.840	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
B	2.60.40.640	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00339	Arrestin (or S-antigen), N-terminal domain (Arrestin_N)	Arrestin (or S-antigen), N-terminal domain	Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.	Domain
A, B, C, D	PF02752	Arrestin (or S-antigen), C-terminal domain (Arrestin_C)	Arrestin (or S-antigen), C-terminal domain	Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	PROTEIN (ARRESTIN)	protein binding binding signaling receptor binding G protein-coupled receptor binding identical protein binding	response to light stimulus response to stimulus response to radiation response to abiotic stimulus cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation cellular process signal transduction cell communication negative adaptation of signaling pathway import into cell response to light stimulus response to stimulus response to radiation response to abiotic stimulus cellular response to stimulus regulation of biological process regulation of cellular process signaling biological regulation cellular process signal transduction cell communication negative adaptation of signaling pathway import into cell receptor internalization negative regulation of signaling transport negative regulation of biological process desensitization of G protein-coupled receptor signaling pathway regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication vesicle-mediated transport localization negative regulation of cellular process regulation of G protein-coupled receptor signaling pathway G protein-coupled receptor internalization regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction establishment of localization regulation of response to stimulus adaptation of signaling pathway regulation of cell communication G protein-coupled receptor signaling pathway receptor-mediated endocytosis endocytosis	cellular anatomical structure membrane photoreceptor inner segment intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle non-motile cilium 9+0 non-motile cilium cilium neuron projection photoreceptor outer segment plasma membrane bounded cell projection cell projection cellular anatomical structure membrane photoreceptor inner segment intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle non-motile cilium 9+0 non-motile cilium cilium neuron projection photoreceptor outer segment plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR017864	Arrestin, conserved site	Conserved Site
A, B, C, D	IPR000698	Arrestin	Family
A, B, C, D	IPR011021	Arrestin-like, N-terminal	Domain
A, B, C, D	IPR011022	Arrestin C-terminal-like domain	Domain
A, B, C, D	IPR014753	Arrestin, N-terminal	Homologous Superfamily
A, B, C, D	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, B, C, D	IPR014752	Arrestin-like, C-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.