Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
A [auth P]d1cf2p1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Methanothermus fervidus ) [TaxId: 2180 ], SCOPe (2.08)
A [auth P]d1cf2p2 Alpha and beta proteins (a+b) FwdE/GAPDH domain-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain GAPDH-like Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Methanothermus fervidus ) [TaxId: 2180 ], SCOPe (2.08)
B [auth R]d1cf2r1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Methanothermus fervidus ) [TaxId: 2180 ], SCOPe (2.08)
B [auth R]d1cf2r2 Alpha and beta proteins (a+b) FwdE/GAPDH domain-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain GAPDH-like Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Methanothermus fervidus ) [TaxId: 2180 ], SCOPe (2.08)
C [auth O]d1cf2o1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Methanothermus fervidus ) [TaxId: 2180 ], SCOPe (2.08)
C [auth O]d1cf2o2 Alpha and beta proteins (a+b) FwdE/GAPDH domain-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain GAPDH-like Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Methanothermus fervidus ) [TaxId: 2180 ], SCOPe (2.08)
D [auth Q]d1cf2q1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Methanothermus fervidus ) [TaxId: 2180 ], SCOPe (2.08)
D [auth Q]d1cf2q2 Alpha and beta proteins (a+b) FwdE/GAPDH domain-like Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain GAPDH-like Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Methanothermus fervidus ) [TaxId: 2180 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth P]SCOP2B SuperfamilyGAPDH-like 8056122 3000043 SCOP2B (2022-06-29)
B [auth R]SCOP2B SuperfamilyGAPDH-like 8056122 3000043 SCOP2B (2022-06-29)
C [auth O]SCOP2 FamilyGlyceraldehyde-3-phosphate dehydrogenase (GAPDH)-like 8056121 4000077 SCOP2 (2022-06-29)
C [auth O]SCOP2 SuperfamilyGAPDH-like 8056122 3000043 SCOP2 (2022-06-29)
D [auth Q]SCOP2B SuperfamilyGAPDH-like 8056122 3000043 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth P]Gp_dh_C_1e1cf2P1 A: a+b two layersX: FwdE/GAPDH domain-likeH: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainF: Gp_dh_C_1ECOD (1.6)
A [auth P]DapB_Ne1cf2P2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: DapB_NECOD (1.6)
B [auth R]Gp_dh_C_1e1cf2R1 A: a+b two layersX: FwdE/GAPDH domain-likeH: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainF: Gp_dh_C_1ECOD (1.6)
B [auth R]DapB_Ne1cf2R2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: DapB_NECOD (1.6)
C [auth O]Gp_dh_C_1e1cf2O1 A: a+b two layersX: FwdE/GAPDH domain-likeH: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainF: Gp_dh_C_1ECOD (1.6)
C [auth O]DapB_Ne1cf2O2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: DapB_NECOD (1.6)
D [auth Q]Gp_dh_C_1e1cf2Q1 A: a+b two layersX: FwdE/GAPDH domain-likeH: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain (From Topology)T: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domainF: Gp_dh_C_1ECOD (1.6)
D [auth Q]DapB_Ne1cf2Q2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: DapB_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth P],
B [auth R],
C [auth O],
D [auth Q]
PF02800Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain (Gp_dh_C)Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domainGAPDH is a tetrameric NAD-binding enzyme involved in glycolysis and glyconeogenesis. C-terminal domain is a mixed alpha/antiparallel beta fold.Domain
A [auth P],
B [auth R],
C [auth O],
D [auth Q]
PF01113Dihydrodipicolinate reductase, N-terminus (DapB_N)Dihydrodipicolinate reductase, N-terminusDihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate. This reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for b ...Dihydrodipicolinate reductase (DapB) reduces the alpha,beta-unsaturated cyclic imine, dihydro-dipicolinate. This reaction is the second committed step in the biosynthesis of L-lysine and its precursor meso-diaminopimelate, which are critical for both protein and cell wall biosynthesis. The N-terminal domain of DapB binds the dinucleotide NADPH.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth P],
B [auth R],
C [auth O],
D [auth Q]
PROTEIN (GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE)

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)  M-CSA #619

Archaebacterial glyceraldehyde-3-phosphate dehydrogenase is able to catalyse the conversion of glycerate-1-3-bisphophate to glyceraldehyde-3-phosphate using NADPH or NADH as the cofactor. It displays homology with the family of GAPDH dehydrogenases including both bacterial and human forms, but is unique in its resistance to extremes of temperature.

Defined by 2 residues: CYS:A-140 [auth P-140]HIS:A-219 [auth P-219]
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Explore in 3DM-CSA Motif Definition