1CGK

CHALCONE SYNTHASE FROM ALFALFA COMPLEXED WITH NARINGENIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1cgka2	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Chalcone synthase-like	Chalcone synthase, C-terminal domain	(Medicago sativa ) [TaxId: 3879 ],	SCOPe (2.08)
A	d1cgka1	Alpha and beta proteins (a/b)	Thiolase-like	Thiolase-like	Chalcone synthase-like	Chalcone synthase, N-terminal domain	(Medicago sativa ) [TaxId: 3879 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Thiolase-like	8033515	3000122	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Thiolase-like	8033512	3000122	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ACP_syn_III_C	e1cgkA2	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: ACP_syn_III_C	ECOD (1.6)
A	Chal_sti_synt_N	e1cgkA1	A: a/b three-layered sandwiches	X: Thiolase-like (From Topology)	H: Thiolase-like (From Topology)	T: Thiolase-like	F: Chal_sti_synt_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.47.10	Alpha Beta	3-Layer(aba) Sandwich	Peroxisomal Thiolase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00195	Chalcone and stilbene synthases, N-terminal domain (Chal_sti_synt_N)	Chalcone and stilbene synthases, N-terminal domain	The C-terminal domain of Chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in this N-terminal domain.	Domain
A	PF02797	Chalcone and stilbene synthases, C-terminal domain (Chal_sti_synt_C)	Chalcone and stilbene synthases, C-terminal domain	This domain of chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in the N-terminal domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN (CHALCONE SYNTHASE)	acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity naringenin-chalcone synthase activity	flavonoid metabolic process flavonoid biosynthetic process biosynthetic process metabolic process polyketide biosynthetic process secondary metabolite biosynthetic process polyketide metabolic process secondary metabolic process phenylpropanoid metabolic process olefinic compound biosynthetic process small molecule biosynthetic process cellular biosynthetic process chalcone metabolic process cellular metabolic process flavonoid metabolic process flavonoid biosynthetic process biosynthetic process metabolic process polyketide biosynthetic process secondary metabolite biosynthetic process polyketide metabolic process secondary metabolic process phenylpropanoid metabolic process olefinic compound biosynthetic process small molecule biosynthetic process cellular biosynthetic process chalcone metabolic process cellular metabolic process phenylpropanoid biosynthetic process chalcone biosynthetic process cellular ketone metabolic process olefinic compound metabolic process small molecule metabolic process cellular process ketone biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001099	Chalcone/stilbene synthase, N-terminal	Domain
A	IPR016039	Thiolase-like	Homologous Superfamily
A	IPR012328	Chalcone/stilbene synthase, C-terminal	Domain
A	IPR011141	Polyketide synthase, type III	Family
A	IPR018088	Chalcone/stilbene synthase, active site	Active Site

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	naringenin-chalcone synthase M-CSA #355	Chalcone synthase (CHS) is pivotal for the biosynthesis of flavonoid antimicrobial phytoalexins and anthocyanin pigments in plants. It produces chalcone by condensing one p-coumaroyl- and three malonyl-coenzyme A thioesters into a polyketide reaction intermediate that cyclises without the involvement of specific catalytic residues.	Defined by 4 residues: CYS:A-164PHE:A-215HIS:A-303ASN:A-336 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 2.3.1.74 (PDB Primary Data) Search M-CSA Motif + EC 2.3.1.74

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.