1CH8

STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI COMPLEXED WITH A STRINGENT EFFECTOR, PPG2':3'P

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ch8a_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Nitrogenase iron protein-like	Adenylosuccinate synthetase, PurA	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Simibi-like P-loop NTPases	8017950	3002018	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Adenylsucc_synt	e1ch8A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Adenylsucc_synt	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.440.10	Alpha Beta	3-Layer(aba) Sandwich	Adenylosuccinate Synthetase	Chain A, domain 1	CATH (4.3.0)
A	1.10.300.10	Mainly Alpha	Orthogonal Bundle	Adenylosuccinate Synthetase, subunit A	domain 2	CATH (4.3.0)
A	3.90.170.10	Alpha Beta	Alpha-Beta Complex	Adenylosuccinate Synthetase	Chain A, domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00709	Adenylosuccinate synthetase (Adenylsucc_synt)	Adenylosuccinate synthetase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN (ADENYLOSUCCINATE SYNTHETASE)	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding guanosine tetraphosphate binding guanyl nucleotide binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding guanosine tetraphosphate binding guanyl nucleotide binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding adenylosuccinate synthase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity GTP binding purine ribonucleoside triphosphate binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleoside phosphate metabolic process nucleotide biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleoside phosphate metabolic process nucleotide biosynthetic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process biosynthetic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process purine-containing compound biosynthetic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process metabolic process small molecule metabolic process phosphorus metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process 'de novo' AMP biosynthetic process purine ribonucleoside monophosphate biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process AMP metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process purine nucleoside monophosphate metabolic process ribose phosphate biosynthetic process nucleoside monophosphate metabolic process carbohydrate derivative biosynthetic process nucleoside monophosphate biosynthetic process AMP biosynthetic process purine ribonucleotide metabolic process ribonucleoside monophosphate biosynthetic process nucleobase-containing small molecule interconversion IMP metabolic process glycosyl compound metabolic process nucleoside biosynthetic process purine ribonucleoside metabolic process glycosyl compound biosynthetic process small molecule biosynthetic process purine ribonucleoside biosynthetic process ribonucleoside biosynthetic process nucleoside metabolic process nucleobase-containing small molecule biosynthetic process adenosine metabolic process purine nucleoside biosynthetic process adenosine biosynthetic process purine nucleoside metabolic process ribonucleoside metabolic process	cellular anatomical structure membrane intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001114	Adenylosuccinate synthetase	Family
A	IPR033128	Adenylosuccinate synthase, active site	Active Site
A	IPR042110	Adenylosuccinate synthetase, domain 2	Homologous Superfamily
A	IPR018220	Adenylosuccinate synthase, GTP-binding site	Binding Site
A	IPR042111	Adenylosuccinate synthetase, domain 3	Homologous Superfamily
A	IPR042109	Adenylosuccinate synthetase, domain 1	Homologous Superfamily
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.