1CKL

N-TERMINAL TWO DOMAINS OF HUMAN CD46 (MEMBRANE COFACTOR PROTEIN, MCP)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ckla1	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	Complement control module/SCR domain	CD46 (membrane cofactor protein, MCP)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1cklb1	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	Complement control module/SCR domain	CD46 (membrane cofactor protein, MCP)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1cklc1	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	Complement control module/SCR domain	CD46 (membrane cofactor protein, MCP)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1ckld1	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	Complement control module/SCR domain	CD46 (membrane cofactor protein, MCP)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1ckle1	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	Complement control module/SCR domain	CD46 (membrane cofactor protein, MCP)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1cklf1	Small proteins	Complement control module/SCR domain	Complement control module/SCR domain	Complement control module/SCR domain	CD46 (membrane cofactor protein, MCP)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043389	3000902	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043390	3000902	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043390	3000902	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043389	3000902	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043389	3000902	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043390	3000902	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043390	3000902	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043389	3000902	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043390	3000902	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043389	3000902	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043389	3000902	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Sushi/CCP/SCR domain	8043390	3000902	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sushi_4	e1cklA1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_4	ECOD (1.6)
A	Sushi	e1cklA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
B	Sushi_4	e1cklB1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_4	ECOD (1.6)
B	Sushi	e1cklB2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
C	Sushi_4	e1cklC1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_4	ECOD (1.6)
C	Sushi	e1cklC2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
D	Sushi_4	e1cklD1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_4	ECOD (1.6)
D	Sushi	e1cklD2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
E	Sushi_4	e1cklE1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_4	ECOD (1.6)
E	Sushi	e1cklE2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)
F	Sushi_4	e1cklF1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi_4	ECOD (1.6)
F	Sushi	e1cklF2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: Complement control module/SCR domain	F: Sushi	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
B	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
C	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
D	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
E	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)
F	2.10.70.10	Mainly Beta	Ribbon	Complement Module	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00084	Sushi repeat (SCR repeat) (Sushi)	Sushi repeat (SCR repeat)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	PROTEIN (CD46)	protein binding binding virus receptor activity exogenous protein binding molecular transducer activity signaling receptor activity cell adhesion molecule binding cadherin binding	regulation of transforming growth factor beta production multicellular organismal process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process transforming growth factor beta production regulation of transforming growth factor beta production multicellular organismal process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process transforming growth factor beta production positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process positive regulation of transforming growth factor beta production positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process cellular response to stimulus regulation of signaling cell surface receptor signaling pathway response to stimulus signaling regulation of signal transduction cell communication Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication signal transduction adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity T cell mediated immunity immune response immune system process leukocyte mediated immunity adaptive immune response immune effector process negative regulation of signaling negative regulation of response to stimulus negative regulation of biological process negative regulation of signal transduction negative regulation of cell communication extracellular negative regulation of signal transduction negative regulation of cellular process sequestering of extracellular ligand from receptor extracellular regulation of signal transduction humoral immune response positive regulation of response to stimulus complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response regulation of immune system process positive regulation of immune system process complement activation, classical pathway immunoglobulin mediated immune response B cell mediated immunity regulation of immune response activation of immune response regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of cell activation T cell activation cell differentiation anatomical structure development positive regulation of leukocyte activation T cell differentiation developmental process positive regulation of T cell activation positive regulation of cell development positive regulation of regulatory T cell differentiation regulation of leukocyte cell-cell adhesion leukocyte differentiation cellular developmental process regulation of developmental process cell development positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of hemopoiesis positive regulation of cell differentiation regulation of cell-cell adhesion regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis positive regulation of cell adhesion regulation of cell adhesion regulation of regulatory T cell differentiation cell activation regulation of T cell activation regulatory T cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus regulation of humoral immune response regulation of immune effector process regulation of humoral immune response mediated by circulating immunoglobulin negative regulation of lymphocyte mediated immunity negative regulation of complement activation, classical pathway negative regulation of B cell mediated immunity regulation of adaptive immune response negative regulation of immune response negative regulation of immune effector process negative regulation of humoral immune response negative regulation of adaptive immune response regulation of B cell mediated immunity negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte mediated immunity negative regulation of immunoglobulin mediated immune response regulation of complement activation, classical pathway regulation of complement activation negative regulation of complement activation regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of immunoglobulin mediated immune response negative regulation of humoral immune response mediated by circulating immunoglobulin regulation of lymphocyte mediated immunity negative regulation of immune system process negative regulation of leukocyte mediated immunity sexual reproduction reproductive process fertilization single fertilization interleukin-10 production regulation of interleukin-10 production positive regulation of interleukin-10 production negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process positive regulation of cell population proliferation lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation positive regulation of leukocyte proliferation leukocyte proliferation positive regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell proliferation regulation of mononuclear cell proliferation immunological memory formation process cell activation involved in immune response positive regulation of memory T cell differentiation memory T cell differentiation T cell activation involved in immune response leukocyte activation involved in immune response positive regulation of immune effector process lymphocyte activation involved in immune response T cell differentiation involved in immune response regulation of memory T cell differentiation immunological memory process	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell surface cell periphery plasma membrane membrane acrosomal vesicle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle acrosomal membrane endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle inner acrosomal membrane secretory granule secretory vesicle cytoplasm organelle membrane secretory granule membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR017341	Membrane cofactor protein CD46	Family
A, B, C, D, E A, B, C, D, E, F	IPR000436	Sushi/SCR/CCP domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR050350	Complement & Cell Adhesion Regulators	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P15529	atypical hemolytic-uremic syndrome measles atypical hemolytic-uremic syndrome with MCP/CD46 anomaly hemolytic-uremic syndrome malignant colon neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm age-related macular degeneration plasma cell myeloma colorectal cancer glioblastoma HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 2 interstitial cystitis large cell medulloblastoma malignant ependymoma atypical hemolytic-uremic syndrome measles atypical hemolytic-uremic syndrome with MCP/CD46 anomaly hemolytic-uremic syndrome malignant colon neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm age-related macular degeneration plasma cell myeloma colorectal cancer glioblastoma HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 2 interstitial cystitis large cell medulloblastoma malignant ependymoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor primitive neuroectodermal tumor atypical teratoid rhabdoid tumor dermatomyositis HELLP syndrome interstitial lung disease lung adenocarcinoma malignant mesothelioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma Pick disease progressive supranuclear palsy breast cancer Gaucher disease hemolytic anemia hereditary spastic paraplegia invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.