1CR5

N-TERMINAL DOMAIN OF SEC18P

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1cr5a1	All beta proteins	Double psi beta-barrel	ADC-like	Cdc48 N-terminal domain-like	N-terminal domain of NSF-N, NSF-Nn	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
A	d1cr5a2	Alpha and beta proteins (a+b)	Cdc48 domain 2-like	Cdc48 domain 2-like	Cdc48 domain 2-like	C-terminal domain of NSF-N, NSF-Nc	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d1cr5b1	All beta proteins	Double psi beta-barrel	ADC-like	Cdc48 N-terminal domain-like	N-terminal domain of NSF-N, NSF-Nn	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d1cr5b2	Alpha and beta proteins (a+b)	Cdc48 domain 2-like	Cdc48 domain 2-like	Cdc48 domain 2-like	C-terminal domain of NSF-N, NSF-Nc	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d1cr5c1	All beta proteins	Double psi beta-barrel	ADC-like	Cdc48 N-terminal domain-like	N-terminal domain of NSF-N, NSF-Nn	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d1cr5c2	Alpha and beta proteins (a+b)	Cdc48 domain 2-like	Cdc48 domain 2-like	Cdc48 domain 2-like	C-terminal domain of NSF-N, NSF-Nc	baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Cdc48 domain 2-like	8022522	4001091	SCOP2 (2022-06-29)
A	SCOP2 Family	Cdc48 N-terminal domain-like	8030153	4002365	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Cdc48 domain 2-like	8034902	3000725	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ADC-like	8042532	3001132	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Cdc48 domain 2-like	8034902	3000725	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ADC-like	8042532	3001132	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ADC-like	8042532	3001132	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cdc48 domain 2-like	8034902	3000725	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CDC48_N	e1cr5A1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: CDC48_N	ECOD (1.6)
A	CDC48_2	e1cr5A2	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: CDC48_2	ECOD (1.6)
B	CDC48_N	e1cr5B1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: CDC48_N	ECOD (1.6)
B	CDC48_2	e1cr5B2	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: CDC48_2	ECOD (1.6)
C	CDC48_N	e1cr5C1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: CDC48_N	ECOD (1.6)
C	CDC48_2	e1cr5C2	A: a+b two layers	X: Cdc48 domain 2-like (From Topology)	H: Cdc48 domain 2-like (From Topology)	T: Cdc48 domain 2-like	F: CDC48_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
A	3.10.330.10	Alpha Beta	Roll	Vcp-like ATPase	Chain A, domain 2	CATH (4.3.0)
B	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
B	3.10.330.10	Alpha Beta	Roll	Vcp-like ATPase	Chain A, domain 2	CATH (4.3.0)
C	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
C	3.10.330.10	Alpha Beta	Roll	Vcp-like ATPase	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF02933	Cell division protein 48 (CDC48), domain 2 (CDC48_2)	Cell division protein 48 (CDC48), domain 2	This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at t ...	This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the C-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate 185-residue recognition domain [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	SEC18P (RESIDUES 22 - 210)	ion binding binding anion binding phosphatidic acid binding phospholipid binding lipid binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding ion binding binding anion binding phosphatidic acid binding phospholipid binding lipid binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding protein binding SNARE binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane localization within membrane protein localization to membrane establishment of localization vesicle-mediated transport to the plasma membrane protein transport macromolecule localization cellular process Golgi vesicle transport autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy cellular metabolic process autophagy autophagosome organization cellular component biogenesis cellular component organization cellular catabolic process organelle organization cellular component assembly metabolic process cellular component organization or biogenesis process utilizing autophagic mechanism organelle fusion vacuole fusion vacuole fusion, non-autophagic establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport cellular component disassembly protein-containing complex organization SNARE complex disassembly protein-containing complex disassembly membrane organization membrane fusion organelle membrane fusion vesicle organization vesicle fusion with Golgi apparatus vesicle fusion Golgi organization endomembrane system organization inter-Golgi cisterna vesicle-mediated transport	membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle Golgi stack cytoplasm cell projection mating projection membrane-bounded organelle intracellular anatomical structure Golgi apparatus subcompartment Golgi apparatus organelle subcompartment cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle Golgi stack cytoplasm cell projection mating projection cell tip mating projection tip cell pole plasma membrane bounded cell projection site of polarized growth cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR004201	CDC48, domain 2	Domain
A, B, C	IPR009010	Aspartate decarboxylase-like domain superfamily	Homologous Superfamily
A, B, C	IPR003593	AAA+ ATPase domain	Domain
A, B, C	IPR003959	ATPase, AAA-type, core	Domain
A, B, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B, C	IPR029067	CDC48 domain 2-like superfamily	Homologous Superfamily
A, B, C	IPR041569	AAA ATPase, AAA+ lid domain	Domain
A, B, C	IPR039812	Vesicle-fusing ATPase	Family
A, B, C	IPR003960	ATPase, AAA-type, conserved site	Conserved Site
A, B, C	IPR003338	CDC48, N-terminal subdomain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.