1D1J

CRYSTAL STRUCTURE OF HUMAN PROFILIN II

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1d1ja_	Alpha and beta proteins (a+b)	Profilin-like	Profilin (actin-binding protein)	Profilin (actin-binding protein)	Profilin (actin-binding protein)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1d1jc_	Alpha and beta proteins (a+b)	Profilin-like	Profilin (actin-binding protein)	Profilin (actin-binding protein)	Profilin (actin-binding protein)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1d1jd_	Alpha and beta proteins (a+b)	Profilin-like	Profilin (actin-binding protein)	Profilin (actin-binding protein)	Profilin (actin-binding protein)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1d1jb_	Alpha and beta proteins (a+b)	Profilin-like	Profilin (actin-binding protein)	Profilin (actin-binding protein)	Profilin (actin-binding protein)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Profilin (actin-binding protein)	8023720	4001840	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Profilin (actin-binding protein)	8036100	3000452	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Profilin (actin-binding protein)	8036100	3000452	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Profilin (actin-binding protein)	8036100	3000452	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Profilin (actin-binding protein)	8036100	3000452	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Profilin	e1d1jA1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Profilin	ECOD (1.6)
C	Profilin	e1d1jC1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Profilin	ECOD (1.6)
D	Profilin	e1d1jD1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Profilin	ECOD (1.6)
B	Profilin	e1d1jB1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Profilin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)
C	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)
D	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)
B	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00235	Profilin (Profilin)	Profilin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	PROFILIN II	binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding cytoskeletal protein binding actin binding protein binding pyrophosphatase activity binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding cytoskeletal protein binding actin binding protein binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity actin monomer binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication regulation of protein stability biological regulation regulation of biological quality protein stabilization trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cellular process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process regulation of cellular component size negative regulation of biological process cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly negative regulation of cellular process negative regulation of protein polymerization regulation of actin filament polymerization negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin filament polymerization negative regulation of cellular component organization protein-containing complex organization negative regulation of cytoskeleton organization actin filament organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis regulation of organelle organization negative regulation of protein-containing complex assembly negative regulation of organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization regulation of anatomical structure size cell junction organization modification of postsynaptic actin cytoskeleton synapse organization modification of postsynaptic structure modification of synaptic structure positive regulation of organelle organization positive regulation of cellular component organization regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization actin filament bundle assembly multicellular organismal process negative regulation of locomotion regulation of cell motility tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration regulation of cell migration regulation of multicellular organismal process cell migration epithelial cell migration cell motility regulation of epithelial cell migration locomotion negative regulation of cell migration epithelium migration regulation of locomotion negative regulation of cell motility negative regulation of multicellular organismal process positive regulation of protein-containing complex assembly positive regulation of protein polymerization positive regulation of actin filament polymerization regulation of localization cellular localization regulated exocytosis transport synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport vesicle-mediated transport in synapse regulation of regulated secretory pathway localization regulation of secretion by cell secretion by cell signal release establishment of localization in cell neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport regulation of synaptic vesicle exocytosis export from cell neurotransmitter transport regulation of vesicle-mediated transport establishment of localization regulation of secretion signal release from synapse exocytosis regulation of neurotransmitter secretion regulation of exocytosis ruffle organization cell projection organization plasma membrane bounded cell projection assembly negative regulation of ruffle assembly ruffle assembly negative regulation of plasma membrane bounded cell projection assembly negative regulation of cell projection organization plasma membrane bounded cell projection organization regulation of cell projection organization regulation of cell projection assembly regulation of plasma membrane bounded cell projection assembly regulation of ruffle assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of ATP-dependent activity positive regulation of stress fiber assembly stress fiber assembly actomyosin structure organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle presynapse synapse cell junction intracellular anatomical structure extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle presynapse synapse cell junction intracellular anatomical structure cytoplasm glutamatergic synapse intracellular organelle cytoskeleton membraneless organelle intracellular membraneless organelle Schaffer collateral - CA1 synapse postsynapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR005455	Profilin, eukaryotic type	Family
A, B, C, D	IPR027310	Profilin conserved site	Conserved Site
A, B, C, D	IPR005454	Profilin1/2/3, vertebrate	Family
A, B, C, D	IPR036140	Profilin superfamily	Homologous Superfamily
A, B, C, D	IPR048278	Profilin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P35080	breast cancer invasive ductal breast carcinoma myocardial infarction pancreatic intraductal papillary-mucinous carcinoma sinusitis glioblastoma lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis interstitial cystitis lung carcinoma osteosarcoma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.