Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1e1aa_ All beta proteins 6-bladed beta-propeller Calcium-dependent phosphotriesterase SGL-like Diisopropylfluorophosphatase (phosphotriesterase, DFP) SQUID (Loligo vulgaris ) [TaxId: 6622 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCalcium-dependent phosphotriesterase 8038159 3000504 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ASGL_1e1e1aA1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 6-bladedF: SGL_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.120.10.30 Mainly Beta 6 Propeller Neuraminidase TolB, C-terminal domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF08450SMP-30/Gluconolactonase/LRE-like region (SGL)SMP-30/Gluconolactonase/LRE-like region- Repeat

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
diisopropyl-fluorophosphatase  M-CSA #686

Diisopropylfluorophosphatase is a calcium metalloenzyme that catalyses the hydrolysis of diisopropyl fluorophosphate and related acetylcholinesterase inhibitors. The potential for this enzyme to detoxify nerve agents used in chemical warfare such as DFP, sarin and tabun. Only this enzyme and one other are expressed in sufficiently high yields.

Defined by 6 residues: GLU:A-21GLU:A-37ASN:A-120ASN:A-175ASP:A-229HIS:A-287
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