Diisopropylfluorophosphatase is a calcium metalloenzyme that catalyses the hydrolysis of diisopropyl fluorophosphate and related acetylcholinesterase inhibitors. The potential for this enzyme to detoxify nerve agents used in chemical warfare such as DFP, sarin and tabun. Only this enzyme and one other are expressed in sufficiently high yields.
Defined by 6 residues: GLU:A-21GLU:A-37ASN:A-120ASN:A-175ASP:A-229HIS:A-287