1EDQ

CRYSTAL STRUCTURE OF CHITINASE A FROM S. MARCESCENS AT 1.55 ANGSTROMS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1edqa1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	E-set domains of sugar-utilizing enzymes	Chitinase A, N-terminal domain N	(Serratia marcescens ) [TaxId: 615 ],	SCOPe (2.08)
A	d1edqa2	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	Type II chitinase	Chitinase A, catalytic domain	(Serratia marcescens ) [TaxId: 615 ],	SCOPe (2.08)
A	d1edqa3	Alpha and beta proteins (a+b)	FKBP-like	Chitinase insertion domain	Chitinase insertion domain	Chitinase A	(Serratia marcescens ) [TaxId: 615 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Chitinase insertion domain	8022497	4001072	SCOP2 (2022-06-29)
A	SCOP2 Family	Type II chitinase	8031010	4003194	SCOP2 (2022-06-29)
A	SCOP2 Family	E-set domains of sugar-utilizing enzymes	8054944	4007565	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Chitinase insertion domain	8034877	3000666	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	(Trans)glycosidases	8043388	3000313	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	E set domains	8054945	3000070	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ChitinaseA_N	e1edqA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: ChitinaseA_N	ECOD (1.6)
A	ChiA	e1edqA2	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: ChiA	ECOD (1.6)
A	Glyco_hydro_18	e1edqA3	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_18	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00704	Glycosyl hydrolases family 18 (Glyco_hydro_18)	Glycosyl hydrolases family 18	-	Domain
A	PF08329	Chitinase A, N-terminal domain (ChitinaseA_N)	Chitinase A, N-terminal domain	This domain is found in a number of bacterial chitinases and similar viral proteins. It is organised into a fibronectin III module domain-like fold, comprising only beta strands. Its function is not known, but it may be involved in interaction with t ...	This domain is found in a number of bacterial chitinases and similar viral proteins. It is organised into a fibronectin III module domain-like fold, comprising only beta strands. Its function is not known, but it may be involved in interaction with the enzyme substrate, chitin [1,2]. It is separated by a hinge region from the catalytic domain (Pfam:PF00704); this hinge region is probably mobile, allowing the N-terminal domain to have different relative positions in solution [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CHITINASE A	chitin binding binding carbohydrate derivative binding chitinase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity	carbohydrate derivative catabolic process catabolic process carbohydrate derivative metabolic process chitin metabolic process aminoglycan catabolic process macromolecule catabolic process glucosamine-containing compound catabolic process amino sugar catabolic process aminoglycan metabolic process amino sugar metabolic process metabolic process macromolecule metabolic process chitin catabolic process glucosamine-containing compound metabolic process carbohydrate derivative catabolic process catabolic process carbohydrate derivative metabolic process chitin metabolic process aminoglycan catabolic process macromolecule catabolic process glucosamine-containing compound catabolic process amino sugar catabolic process aminoglycan metabolic process amino sugar metabolic process metabolic process macromolecule metabolic process chitin catabolic process glucosamine-containing compound metabolic process carbohydrate metabolic process polysaccharide metabolic process polysaccharide catabolic process carbohydrate catabolic process primary metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR029070	Chitinase insertion domain superfamily	Homologous Superfamily
A	IPR022409	PKD/Chitinase domain	Domain
A	IPR001579	Glycosyl hydrolase family 18, active site	Active Site
A	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A	IPR050314	Glycosyl Hydrolase Family 18	Family
A	IPR001223	Glycoside hydrolase family 18, catalytic domain	Domain
A	IPR013540	Chitinase A N-terminal	Domain
A	IPR011583	Chitinase II/V-like, catalytic domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR014756	Immunoglobulin E-set	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.