1EEM

GLUTATHIONE TRANSFERASE FROM HOMO SAPIENS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1eema1	All alpha proteins	GST C-terminal domain-like	GST C-terminal domain-like	Glutathione S-transferase (GST), C-terminal domain	Class omega GST	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1eema2	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Glutathione S-transferase (GST), N-terminal domain	Class omega GST	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Glutathione S-transferase (GST), C-terminal domain	8025171	4000976	SCOP2 (2022-06-29)
A	SCOP2 Family	Glutathione S-transferase (GST), N-terminal domain	8031999	4000472	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GST C-terminal domain-like	8037550	3000305	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioredoxin-like	8044377	3000031	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GST_C_3	e1eemA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: GST_C_3	ECOD (1.6)
A	GST_N	e1eemA2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: GST_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
A	1.20.1050.10	Mainly Alpha	Up-down Bundle	Glutathione S-transferase Yfyf (Class Pi)	Chain A, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13409	Glutathione S-transferase, N-terminal domain (GST_N_2)	Glutathione S-transferase, N-terminal domain	This family is closely related to Pfam:PF02798.	Domain
A	PF14497	Glutathione S-transferase, C-terminal domain (GST_C_3)	Glutathione S-transferase, C-terminal domain	This domain is closely related to Pfam:PF00043.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	GLUTATHIONE-S-TRANSFERASE	oxidoreductase activity catalytic activity oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor methylarsonate reductase activity oxidoreductase activity, acting on phosphorus or arsenic in donors glutathione transferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups oxidoreductase activity, acting on a sulfur group of donors disulfide oxidoreductase activity antioxidant activity glutathione disulfide oxidoreductase activity glutathione dehydrogenase (ascorbate) activity oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor	regulation of calcium ion transmembrane transporter activity regulation of localization regulation of calcium ion transport positive regulation of cation transmembrane transport positive regulation of calcium ion transport regulation of cellular process intracellular calcium ion homeostasis negative regulation of biological process calcium ion transport localization positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation homeostasis monoatomic cation transport regulation of calcium ion transmembrane transporter activity regulation of localization regulation of calcium ion transport positive regulation of cation transmembrane transport positive regulation of calcium ion transport regulation of cellular process intracellular calcium ion homeostasis negative regulation of biological process calcium ion transport localization positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of biological process regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization positive regulation of cation channel activity regulation of cation channel activity inorganic cation transmembrane transport maintenance of location transmembrane transport regulation of molecular function release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis cellular localization inorganic ion homeostasis transport homeostatic process monoatomic ion transmembrane transport positive regulation of biological process regulation of transmembrane transporter activity calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport regulation of transporter activity maintenance of location in cell monoatomic cation transmembrane transport regulation of calcium ion transmembrane transport positive regulation of molecular function positive regulation of calcium ion transmembrane transporter activity intracellular monoatomic cation homeostasis positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport monoatomic ion homeostasis negative regulation of cellular process monoatomic ion transport intracellular chemical homeostasis positive regulation of release of sequestered calcium ion into cytosol regulation of metal ion transport regulation of sequestering of calcium ion positive regulation of cellular process positive regulation of ryanodine-sensitive calcium-release channel activity regulation of monoatomic ion transmembrane transporter activity calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion biological regulation cellular homeostasis regulation of ryanodine-sensitive calcium-release channel activity positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity cellular process regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport negative regulation of ion transmembrane transporter activity negative regulation of calcium ion transmembrane transporter activity negative regulation of ryanodine-sensitive calcium-release channel activity negative regulation of transport negative regulation of cation transmembrane transport negative regulation of calcium ion transmembrane transport negative regulation of cation channel activity negative regulation of monoatomic ion transport negative regulation of transmembrane transport positive regulation of sequestering of calcium ion negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol negative regulation of transporter activity negative regulation of molecular function negative regulation of calcium ion transport cellular response to stimulus multicellular organismal process system process response to stimulus regulation of system process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum intracellular signal transduction cell communication multicellular organismal movement regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion positive regulation of striated muscle contraction intracellular signaling cassette signal transduction regulation of skeletal muscle contraction by calcium ion signaling release of sequestered calcium ion into cytosol by endoplasmic reticulum positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion skeletal muscle contraction muscle contraction regulation of striated muscle contraction regulation of muscle contraction calcium-mediated signaling positive regulation of muscle contraction positive regulation of multicellular organismal process signaling striated muscle contraction musculoskeletal movement regulation of skeletal muscle contraction regulation of multicellular organismal process nervous system process neuromuscular process muscle system process regulation of muscle system process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum catabolic process cellular response to xenobiotic stimulus xenobiotic catabolic process xenobiotic metabolic process response to xenobiotic stimulus cellular response to chemical stimulus response to chemical metabolic process cellular response to arsenic-containing substance response to arsenic-containing substance regulation of heart contraction cardiac muscle contraction circulatory system process regulation of cardiac muscle contraction regulation of blood circulation heart process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion blood circulation regulation of cardiac muscle contraction by calcium ion signaling heart contraction monosaccharide metabolic process carbohydrate metabolic process oxoacid metabolic process carboxylic acid metabolic process primary metabolic process organic acid metabolic process L-ascorbic acid metabolic process vitamin metabolic process lactone metabolic process small molecule metabolic process water-soluble vitamin metabolic process glutathione metabolic process modified amino acid metabolic process sulfur compound metabolic process amide metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004046	Glutathione S-transferase, C-terminal	Domain
A	IPR010987	Glutathione S-transferase, C-terminal-like	Domain
A	IPR045073	Glutathione S-transferase Omega/Tau-like	Family
A	IPR004045	Glutathione S-transferase, N-terminal	Domain
A	IPR050983	Glutathione S-transferase Omega/HSP26	Family
A	IPR036282	Glutathione S-transferase, C-terminal domain superfamily	Homologous Superfamily
A	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
A	IPR005442	Glutathione S-transferase, omega-class	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P78417	esophageal squamous cell carcinoma plasma cell myeloma prostate cancer cancer leukemia ovarian cancer precancerous condition Prostatic Neoplasms tuberculosis astrocytic tumor lung cancer lymphoplasmacytic lymphoma neurodegenerative disease pancreatic ductal adenocarcinoma benign neoplasm esophageal squamous cell carcinoma plasma cell myeloma prostate cancer cancer leukemia ovarian cancer precancerous condition Prostatic Neoplasms tuberculosis astrocytic tumor lung cancer lymphoplasmacytic lymphoma neurodegenerative disease pancreatic ductal adenocarcinoma benign neoplasm cystic fibrosis large cell medulloblastoma lung disease medulloblastoma skin disease drug-induced liver injury

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.