1EKB

THE SERINE PROTEASE DOMAIN OF ENTEROPEPTIDASE BOUND TO INHIBITOR VAL-ASP-ASP-ASP-ASP-LYS-CHLOROMETHANE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1ekbb_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	Enteropeptidase (enterokinase light chain)	cattle (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Eukaryotic proteases	8029835	4000286	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Trypsin-like serine proteases	8042214	3000114	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Trypsin_1	e1ekbB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: Trypsin_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ENTEROPEPTIDASE	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	multicellular organismal process digestion protein digestion zymogen activation cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing metabolic process multicellular organismal process digestion protein digestion zymogen activation cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing metabolic process cellular process trypsinogen activation protein metabolic process macromolecule metabolic process	membrane cellular anatomical entity
B	ENTEROPEPTIDASE	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	multicellular organismal process digestion protein digestion zymogen activation cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing metabolic process multicellular organismal process digestion protein digestion zymogen activation cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation biosynthetic process proteolysis protein processing metabolic process cellular process trypsinogen activation protein metabolic process macromolecule metabolic process	membrane cellular anatomical entity
C	VAL-ASP-ASP-ASP-ASP-LYK PEPTIDE	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017448	SRCR-like_dom	Unknown
A	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat	Repeat
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR001190	SRCR domain	Domain
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A	IPR035914	Spermadhesin, CUB domain superfamily	Homologous Superfamily
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR036772	SRCR-like domain superfamily	Homologous Superfamily
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR000998	MAM domain	Domain
A	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site	Conserved Site
A	IPR036055	LDL receptor-like superfamily	Homologous Superfamily
A	IPR036364	SEA domain superfamily	Homologous Superfamily
A	IPR000859	CUB domain	Domain
A	IPR011163	Peptidase S1A, enteropeptidase	Family
A	IPR000082	SEA domain	Domain
A	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
B	IPR017448	SRCR-like_dom	Unknown
B	IPR002172	Low-density lipoprotein (LDL) receptor class A repeat	Repeat
B	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B	IPR001190	SRCR domain	Domain
B	IPR001314	Peptidase S1A, chymotrypsin family	Family
B	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
B	IPR035914	Spermadhesin, CUB domain superfamily	Homologous Superfamily
B	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
B	IPR036772	SRCR-like domain superfamily	Homologous Superfamily
B	IPR001254	Serine proteases, trypsin domain	Domain
B	IPR000998	MAM domain	Domain
B	IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site	Conserved Site
B	IPR036055	LDL receptor-like superfamily	Homologous Superfamily
B	IPR036364	SEA domain superfamily	Homologous Superfamily
B	IPR000859	CUB domain	Domain
B	IPR011163	Peptidase S1A, enteropeptidase	Family
B	IPR000082	SEA domain	Domain
B	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site