1EKX

THE ISOLATED, UNREGULATED CATALYTIC TRIMER OF ASPARTATE TRANSCARBAMOYLASE COMPLEXED WITH BISUBSTRATE ANALOG PALA (N-(PHOSPHONACETYL)-L-ASPARTATE)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ekxa1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	Aspartate/ornithine carbamoyltransferase	Aspartate carbamoyltransferase catalytic subunit	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1ekxb1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	Aspartate/ornithine carbamoyltransferase	Aspartate carbamoyltransferase catalytic subunit	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1ekxc1	Alpha and beta proteins (a/b)	ATC-like	Aspartate/ornithine carbamoyltransferase	Aspartate/ornithine carbamoyltransferase	Aspartate carbamoyltransferase catalytic subunit	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Aspartate/ornithine carbamoyltransferase	8020456	4000794	SCOP2 (2022-06-29)
A	SCOP2 Family	Aspartate/ornithine carbamoyltransferase	8020459	4000794	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aspartate/ornithine carbamoyltransferase	8032836	3001396	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aspartate/ornithine carbamoyltransferase	8032839	3001396	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Aspartate/ornithine carbamoyltransferase	8032836	3001396	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Aspartate/ornithine carbamoyltransferase	8032839	3001396	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Aspartate/ornithine carbamoyltransferase	8032836	3001396	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Aspartate/ornithine carbamoyltransferase	8032839	3001396	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	OTCace	e1ekxA2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace	ECOD (1.6)
A	OTCace_N	e1ekxA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace_N	ECOD (1.6)
B	OTCace	e1ekxB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace	ECOD (1.6)
B	OTCace_N	e1ekxB2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace_N	ECOD (1.6)
C	OTCace	e1ekxC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace	ECOD (1.6)
C	OTCace_N	e1ekxC2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Aspartate/ornithine carbamoyltransferase	F: OTCace_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (4.3.0)
B	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (4.3.0)
C	3.40.50.1370	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Aspartate/ornithine carbamoyltransferase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF02729	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain (OTCace_N)	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain	-	Domain
A, B, C	PF00185	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain (OTCace)	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	ASPARTATE TRANSCARBAMOYLASE	aspartate carbamoyltransferase activity carboxyl- or carbamoyltransferase activity transferase activity, transferring one-carbon groups transferase activity catalytic activity binding amino acid binding identical protein binding protein binding	pyrimidine-containing compound metabolic process nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process primary metabolic process nucleobase-containing compound metabolic process pyrimidine nucleobase metabolic process biosynthetic process nucleobase-containing small molecule metabolic process nucleobase metabolic process 'de novo' pyrimidine nucleobase biosynthetic process small molecule metabolic process metabolic process pyrimidine-containing compound biosynthetic process glutamine metabolic process pyrimidine-containing compound metabolic process nucleobase biosynthetic process pyrimidine nucleobase biosynthetic process primary metabolic process nucleobase-containing compound metabolic process pyrimidine nucleobase metabolic process biosynthetic process nucleobase-containing small molecule metabolic process nucleobase metabolic process 'de novo' pyrimidine nucleobase biosynthetic process small molecule metabolic process metabolic process pyrimidine-containing compound biosynthetic process glutamine metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process glutamine family amino acid metabolic process proteinogenic amino acid metabolic process cellular process protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis ribose phosphate metabolic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process 'de novo' UMP biosynthetic process ribonucleotide biosynthetic process UMP biosynthetic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process phosphate-containing compound metabolic process UMP metabolic process phosphorus metabolic process nucleoside monophosphate metabolic process ribose phosphate biosynthetic process pyrimidine ribonucleotide metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process pyrimidine nucleoside monophosphate metabolic process pyrimidine ribonucleoside monophosphate metabolic process nucleobase-containing compound biosynthetic process nucleotide metabolic process nucleoside monophosphate biosynthetic process pyrimidine ribonucleoside monophosphate biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process pyrimidine nucleoside monophosphate biosynthetic process ribonucleoside monophosphate biosynthetic process pyrimidine nucleotide biosynthetic process pyrimidine ribonucleotide biosynthetic process	protein-containing complex catalytic complex aspartate carbamoyltransferase complex transferase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR006132	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding	Domain
A, B, C	IPR006131	Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain	Domain
A, B, C	IPR036901	Aspartate/ornithine carbamoyltransferase superfamily	Homologous Superfamily
A, B, C	IPR006130	Aspartate/ornithine carbamoyltransferase	Family
A, B, C	IPR002082	Aspartate carbamoyltransferase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.