Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyNuclear receptor ligand-binding domain 8026316 4001384 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyNuclear receptor ligand-binding domain 8038695 3001442 SCOP2 (2022-06-29)
B [auth D]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8035649 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHormone_recepe1fm9A1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
B [auth D]Hormone_recep_1e1fm9D1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recep_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
B [auth D]1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain
B [auth D]PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
RETINOIC ACID RECEPTOR RXR-ALPHA
B [auth D]PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
C [auth B],
D [auth E]
STEROID RECEPTOR COACTIVATOR

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
IPR021780Nuclear/hormone receptor activator site AF-1Domain
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
IPR000003Retinoid X receptor/HNF4Family
IPR050274Nuclear hormone receptor family NR2 subfamilyFamily
IPR001723Nuclear hormone receptorFamily
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
B [auth D]IPR001628Zinc finger, nuclear hormone receptor-typeDomain
B [auth D]IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
B [auth D]IPR001723Nuclear hormone receptorFamily
B [auth D]IPR003077Peroxisome proliferator-activated receptor gammaFamily
B [auth D]IPR000536Nuclear hormone receptor, ligand-binding domainDomain
B [auth D]IPR003074Peroxisome proliferator-activated receptorFamily
B [auth D]IPR050234Nuclear hormone receptor family NR1 subfamilyFamily
B [auth D]IPR022590Peroxisome proliferator-activated receptor gamma, N-terminalDomain
B [auth D]IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
C [auth B],
D [auth E]
IPR010011Nuclear receptor coactivator, DUF1518Domain
C [auth B],
D [auth E]
IPR028819Nuclear receptor coactivator 1, basic helix-loop-helixDomain
C [auth B],
D [auth E]
IPR009110Nuclear receptor coactivator, interlockingHomologous Superfamily
C [auth B],
D [auth E]
IPR017426Nuclear receptor coactivatorFamily
C [auth B],
D [auth E]
IPR014935Nuclear receptor coactivator, receptor-binding domainDomain
C [auth B],
D [auth E]
IPR014920Nuclear receptor coactivator, Ncoa-type, interlockingDomain
C [auth B],
D [auth E]
IPR035965PAS domain superfamilyHomologous Superfamily
C [auth B],
D [auth E]
IPR036638Helix-loop-helix DNA-binding domain superfamilyHomologous Superfamily
C [auth B],
D [auth E]
IPR037077Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyHomologous Superfamily
C [auth B],
D [auth E]
IPR013767PAS foldDomain
C [auth B],
D [auth E]
IPR000014PAS domainDomain
C [auth B],
D [auth E]
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP19793
B [auth D]PharosP37231
C [auth B],
D [auth E]
PharosQ15788