1G0H

CRYSTAL STRUCTURE OF MJ0109 GENE PRODUCT INOSITOL MONOPHOSPHATASE-FRUCTOSE 1,6 BISPHOSPHATASE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1g0ha_	Multi-domain proteins (alpha and beta)	Carbohydrate phosphatase	Carbohydrate phosphatase	Inositol monophosphatase/fructose-1,6-bisphosphatase-like	Archaeal inositol monophosphatase/fructose-1,6-bisphosphatase	(Methanocaldococcus jannaschii ) [TaxId: 2190 ],	SCOPe (2.08)
B	d1g0hb_	Multi-domain proteins (alpha and beta)	Carbohydrate phosphatase	Carbohydrate phosphatase	Inositol monophosphatase/fructose-1,6-bisphosphatase-like	Archaeal inositol monophosphatase/fructose-1,6-bisphosphatase	(Methanocaldococcus jannaschii ) [TaxId: 2190 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Inositol monophosphatase/fructose-1, 6-bisphosphatase-like	8020125	4002766	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Carbohydrate phosphatase-like	8032505	3001721	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Carbohydrate phosphatase-like	8032505	3001721	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Inositol_P_N	e1g0hA1	A: a+b two layers	X: a+b domain in carbohydrate phosphatases (From Topology)	H: a+b domain in carbohydrate phosphatases (From Topology)	T: a+b domain in carbohydrate phosphatases	F: Inositol_P_N	ECOD (1.6)
A	Inositol_P_C	e1g0hA2	A: a/b three-layered sandwiches	X: Rossmann-like domain in carbohydrate phosphatases (From Homology)	H: Rossmann-like domain in carbohydrate phosphatases	T: Rossmann-like domain in carbohydrate phosphatases	F: Inositol_P_C	ECOD (1.6)
B	Inositol_P_N	e1g0hB1	A: a+b two layers	X: a+b domain in carbohydrate phosphatases (From Topology)	H: a+b domain in carbohydrate phosphatases (From Topology)	T: a+b domain in carbohydrate phosphatases	F: Inositol_P_N	ECOD (1.6)
B	Inositol_P_C	e1g0hB2	A: a/b three-layered sandwiches	X: Rossmann-like domain in carbohydrate phosphatases (From Homology)	H: Rossmann-like domain in carbohydrate phosphatases	T: Rossmann-like domain in carbohydrate phosphatases	F: Inositol_P_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.540.10	Alpha Beta	2-Layer Sandwich	Fructose-1,6-Bisphosphatase	Chain A, domain 1	CATH (4.3.0)
A	3.40.190.80	Alpha Beta	3-Layer(aba) Sandwich	D-Maltodextrin-Binding Protein	domain 2	CATH (4.3.0)
B	3.30.540.10	Alpha Beta	2-Layer Sandwich	Fructose-1,6-Bisphosphatase	Chain A, domain 1	CATH (4.3.0)
B	3.40.190.80	Alpha Beta	3-Layer(aba) Sandwich	D-Maltodextrin-Binding Protein	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00459	Inositol monophosphatase family (Inositol_P)	Inositol monophosphatase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	INOSITOL MONOPHOSPHATASE	phosphoric ester hydrolase activity inositol monophosphate phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds inositol monophosphate 4-phosphatase activity phosphatase activity hydrolase activity catalytic activity inositol monophosphate 3-phosphatase activity inositol monophosphate 1-phosphatase activity fructose 1,6-bisphosphate 1-phosphatase activity carbohydrate phosphatase activity sugar-phosphatase activity cation binding phosphoric ester hydrolase activity inositol monophosphate phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds inositol monophosphate 4-phosphatase activity phosphatase activity hydrolase activity catalytic activity inositol monophosphate 3-phosphatase activity inositol monophosphate 1-phosphatase activity fructose 1,6-bisphosphate 1-phosphatase activity carbohydrate phosphatase activity sugar-phosphatase activity cation binding ion binding binding metal ion binding small molecule binding	polyol metabolic process inositol metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular process signal transduction polyol metabolic process inositol metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular process signal transduction cell communication phosphatidylinositol metabolic process glycerophospholipid biosynthetic process cellular biosynthetic process cellular metabolic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process phosphate-containing compound metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR020550	Inositol monophosphatase, conserved site	Conserved Site
A, B	IPR020583	Inositol monophosphatase, metal-binding site	Binding Site
A, B	IPR000760	Inositol monophosphatase-like	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.