1GOH

NOVEL THIOETHER BOND REVEALED BY A 1.7 ANGSTROMS CRYSTAL STRUCTURE OF GALACTOSE OXIDASE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1goha1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	E-set domains of sugar-utilizing enzymes	Galactose oxidase, C-terminal domain	(Hypomyces rosellus ) [TaxId: 5132 ],	SCOPe (2.08)
A	d1goha2	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	Galactose-binding domain	Galactose oxidase, N-terminal domain	(Hypomyces rosellus ) [TaxId: 5132 ],	SCOPe (2.08)
A	d1goha3	All beta proteins	7-bladed beta-propeller	Galactose oxidase, central domain	Galactose oxidase, central domain	Galactose oxidase, central domain	(Hypomyces rosellus ) [TaxId: 5132 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Galactose oxidase, central domain	8042844	3001660	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	E set domains	8054887	3000070	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	galactose-binding domain-like	8041133	3000087	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F5_F8_type_C_1	e1gohA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: F5_F8_type_C_1	ECOD (1.6)
A	DUF1929	e1gohA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: DUF1929	ECOD (1.6)
A	Glyoxal_oxid_N	e1gohA3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Glyoxal_oxid_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)
A	2.130.10.80	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00754	F5/8 type C domain (F5_F8_type_C)	F5/8 type C domain	This domain is also known as the discoidin (DS) domain family [1].	Domain
A	PF09118	Galactose oxidase-like, Early set domain (GO-like_E_set)	Galactose oxidase-like, Early set domain	E or 'early' set domains are associated with the catalytic domain of galactose oxidase at the C-terminal end. Galactose oxidase is an extracellular monomeric enzyme which catalyzes the stereospecific oxidation of a broad range of primary alcohol subs ...	E or 'early' set domains are associated with the catalytic domain of galactose oxidase at the C-terminal end. Galactose oxidase is an extracellular monomeric enzyme which catalyzes the stereospecific oxidation of a broad range of primary alcohol substrates, and possesses a unique mononuclear copper site essential for catalysing a two-electron transfer reaction during the oxidation of primary alcohols to corresponding aldehydes. The second redox active centre necessary for the reaction was found to be situated at a tyrosine residue. The C-terminal domain of galactose oxidase may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end, and may be involved in homodimeric/tetrameric/dodecameric interactions. Members of this family adopt a secondary structure consisting of a bundle of seven, mostly antiparallel, beta-strands surrounding a hydrophobic core. The 7 strands are arranged in 2 sheets, in a Greek-key topology [1]. This domain is found in sugar-utilising enzymes, such as galactose oxidase or chitinase [2-6].	Domain
A	PF01344	Kelch motif (Kelch_1)	Kelch motif	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	GALACTOSE OXIDASE	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor oxidoreductase activity galactose oxidase activity oxidoreductase activity, acting on CH-OH group of donors catalytic activity cation binding ion binding binding metal ion binding small molecule binding	-	cellular anatomical structure extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000421	Coagulation factor 5/8, C-terminal domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR015202	Galactose oxidase-like, Early set domain	Domain
A	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A	IPR037293	Galactose oxidase, central domain superfamily	Homologous Superfamily
A	IPR006652	Kelch repeat type 1	Repeat
A	IPR011043	Galactose oxidase/kelch, beta-propeller	Homologous Superfamily
A	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.