Annotations: 1GUP

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1gupc1	Alpha and beta proteins (a+b)	HIT-like	HIT-like	Hexose-1-phosphate uridylyltransferase	Galactose-1-phosphate uridylyltransferase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1gupd1	Alpha and beta proteins (a+b)	HIT-like	HIT-like	Hexose-1-phosphate uridylyltransferase	Galactose-1-phosphate uridylyltransferase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1gupa1	Alpha and beta proteins (a+b)	HIT-like	HIT-like	Hexose-1-phosphate uridylyltransferase	Galactose-1-phosphate uridylyltransferase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1gupb1	Alpha and beta proteins (a+b)	HIT-like	HIT-like	Hexose-1-phosphate uridylyltransferase	Galactose-1-phosphate uridylyltransferase	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	HIT-like	8034403	3000223	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	HIT-like	8034400	3000223	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HIT-like	8034403	3000223	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HIT-like	8034400	3000223	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	HIT-like	8034403	3000223	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	HIT-like	8034400	3000223	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HIT-like	8034403	3000223	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HIT-like	8034400	3000223	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	GalP_UDP_transf	e1gupC1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: GalP_UDP_transf	ECOD (1.6)
C	GalP_UDP_tr_C	e1gupC2	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: GalP_UDP_tr_C	ECOD (1.6)
D	GalP_UDP_transf	e1gupD1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: GalP_UDP_transf	ECOD (1.6)
D	GalP_UDP_tr_C	e1gupD2	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: GalP_UDP_tr_C	ECOD (1.6)
A	GalP_UDP_transf	e1gupA1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: GalP_UDP_transf	ECOD (1.6)
A	GalP_UDP_tr_C	e1gupA2	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: GalP_UDP_tr_C	ECOD (1.6)
B	GalP_UDP_transf	e1gupB1	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: GalP_UDP_transf	ECOD (1.6)
B	GalP_UDP_tr_C	e1gupB2	A: a+b three layers	X: HIT-like	H: HIT-related (From Topology)	T: HIT-related	F: GalP_UDP_tr_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
D	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
A	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)
B	3.30.428.10	Alpha Beta	2-Layer Sandwich	HIT family, subunit A	HIT-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01087	Galactose-1-phosphate uridyl transferase, N-terminal domain (GalP_UDP_transf)	Galactose-1-phosphate uridyl transferase, N-terminal domain	SCOP reports fold duplication with C-terminal domain. Both involved in Zn and Fe binding.	Domain
A, B, C, D	PF02744	Galactose-1-phosphate uridyl transferase, C-terminal domain (GalP_UDP_tr_C)	Galactose-1-phosphate uridyl transferase, C-terminal domain	SCOP reports fold duplication with N-terminal domain. Both involved in Zn and Fe binding.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE	cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding UDP-glucose:hexose-1-phosphate uridylyltransferase activity uridylyltransferase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding UDP-glucose:hexose-1-phosphate uridylyltransferase activity uridylyltransferase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups zinc ion binding galactokinase activity carbohydrate kinase activity kinase activity phosphotransferase activity, alcohol group as acceptor	monosaccharide metabolic process carbohydrate metabolic process catabolic process hexose catabolic process carbohydrate catabolic process galactose catabolic process hexose metabolic process primary metabolic process galactose metabolic process galactose catabolic process via UDP-galactose small molecule metabolic process metabolic process monosaccharide catabolic process small molecule catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR001937	Galactose-1-phosphate uridyl transferase, class I	Family
A, B, C, D	IPR019779	Galactose-1-phosphate uridyl transferase, class I His-active site	Active Site
A, B, C, D	IPR036265	HIT-like superfamily	Homologous Superfamily
A, B, C, D	IPR005849	Galactose-1-phosphate uridyl transferase, N-terminal	Domain
A, B, C, D	IPR005850	Galactose-1-phosphate uridyl transferase, C-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.