1GXY

crystal structure of the eucaryotic mono-ADP-ribosyltransferase ART2.2; CRYSTAL FORM A (P21)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1gxya_	Alpha and beta proteins (a+b)	ADP-ribosylation	ADP-ribosylation	Ecto-ART	Eukaryotic mono-ADP-ribosyltransferase ART2.2	RAT (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1gxyb_	Alpha and beta proteins (a+b)	ADP-ribosylation	ADP-ribosylation	Ecto-ART	Eukaryotic mono-ADP-ribosyltransferase ART2.2	RAT (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ecto-ART	8029922	4003346	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ADP-ribosylation	8042301	3001208	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ADP-ribosylation	8042301	3001208	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ART	e1gxyA1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: ART	ECOD (1.6)
B	ART	e1gxyB1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: ART	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.176.10	Alpha Beta	Alpha-Beta Complex	Toxin ADP-ribosyltransferase	Chain A, domain 1	CATH (4.3.0)
B	3.90.176.10	Alpha Beta	Alpha-Beta Complex	Toxin ADP-ribosyltransferase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01129	NAD:arginine ADP-ribosyltransferase (ART)	NAD:arginine ADP-ribosyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	T-CELL ECTO-ADP-RIBOSYLTRANSFERASE 2	pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity NAD+-protein ADP-ribosyltransferase activity transferase activity catalytic activity NAD+-protein poly-ADP-ribosyltransferase activity hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleosidase activity hydrolase activity, hydrolyzing N-glycosyl compounds NAD+ nucleotidase, cyclic ADP-ribose generating nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity NAD+-protein ADP-ribosyltransferase activity transferase activity catalytic activity NAD+-protein poly-ADP-ribosyltransferase activity hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleosidase activity hydrolase activity, hydrolyzing N-glycosyl compounds NAD+ nucleotidase, cyclic ADP-ribose generating nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups NAD+-protein-arginine ADP-ribosyltransferase activity	pyridine nucleotide catabolic process catabolic process organophosphate catabolic process nucleoside phosphate catabolic process NAD metabolic process nucleobase-containing compound metabolic process NAD catabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process pyridine nucleotide catabolic process catabolic process organophosphate catabolic process nucleoside phosphate catabolic process NAD metabolic process nucleobase-containing compound metabolic process NAD catabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleotide catabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process purine nucleotide catabolic process cellular metabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process purine-containing compound metabolic process organophosphate metabolic process metabolic process cellular process pyridine-containing compound catabolic process	membrane cellular anatomical entity side of membrane cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000768	NAD:arginine ADP-ribosyltransferase, ART	Family
A, B	IPR050999	Arg-specific ADP-ribosyltransferase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.