1H0A

Epsin ENTH bound to Ins(1,4,5)P3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1h0aa_	All alpha proteins	alpha-alpha superhelix	ENTH/VHS domain	ENTH domain	Epsin 1	RAT (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ENTH/VHS domain-like	8038653	3000164	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ENTH	e1h0aA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: ENTH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.90	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01417	ENTH domain (ENTH)	ENTH domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	EPSIN	clathrin binding protein binding binding phospholipid binding lipid binding transmembrane transporter binding cargo adaptor activity clathrin adaptor activity protein-macromolecule adaptor activity molecular adaptor activity molecular sequestering activity	multicellular organismal process regulation of sprouting angiogenesis regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development multicellular organism development tube morphogenesis anatomical structure development regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development developmental process multicellular organismal process regulation of sprouting angiogenesis regulation of developmental process negative regulation of biological process angiogenesis regulation of vasculature development multicellular organism development tube morphogenesis anatomical structure development regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development developmental process regulation of multicellular organismal development regulation of biological process blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process biological regulation negative regulation of angiogenesis sprouting angiogenesis vasculature development circulatory system development anatomical structure morphogenesis negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process negative regulation of sprouting angiogenesis multi-multicellular organism process reproductive process female pregnancy multi-organism reproductive process localization import into cell transport cellular process endocytosis establishment of localization vesicle-mediated transport positive regulation of clathrin coat assembly regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of biological process regulation of clathrin coat assembly regulation of cellular component biogenesis clathrin coat assembly cellular component organization cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development animal organ development embryonic organ development membrane organization membrane fission cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication Notch signaling pathway signal transduction	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane clathrin-coated pit endomembrane system axon neuron projection cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane clathrin-coated pit endomembrane system axon neuron projection axon terminus plasma membrane bounded cell projection presynapse cell projection distal axon terminal bouton neuron projection terminus intracellular anatomical structure cytoplasm cytosol presynaptic membrane membrane-bounded organelle protein-containing complex vesicle coat intracellular vesicle membrane protein complex membrane coat intracellular organelle bounding membrane of organelle vesicle membrane cytoplasmic vesicle clathrin-coated vesicle clathrin vesicle coat coated vesicle vesicle clathrin-coated vesicle membrane coated membrane intracellular membrane-bounded organelle clathrin coat coated vesicle membrane cytoplasmic vesicle membrane organelle organelle membrane endosome Schaffer collateral - CA1 synapse nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008942	ENTH/VHS	Homologous Superfamily
A	IPR013809	ENTH domain	Domain
A	IPR003903	Ubiquitin interacting motif	Conserved Site

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Monotopic/peripheral	All alpha monotopic/peripheral	ENTH/VHS domain	ENTH domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.