Annotations: 1HE2

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1he2a_	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	Biliverdin IX beta reductase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SDR-like	8057151	3000038	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	NAD_binding_10	e1he2A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: NAD_binding_10	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13460	NAD(P)H-binding (NAD_binding_10)	NAD(P)H-binding	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	BILIVERDIN IX BETA REDUCTASE	oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor biliverdin reductase [NAD(P)+] activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity FMN reductase (NADH) activity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-NH group of donors biliverdin reductase (NADP+) activity transferase activity, transferring nitrogenous groups catalytic activity, acting on a protein peptidyl-cysteine S-nitrosylase activity transferase activity biliberdin reductase (NAD+) activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor biliverdin reductase [NAD(P)+] activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity FMN reductase (NADH) activity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-NH group of donors biliverdin reductase (NADP+) activity transferase activity, transferring nitrogenous groups catalytic activity, acting on a protein peptidyl-cysteine S-nitrosylase activity transferase activity biliberdin reductase (NAD+) activity FMN reductase (NADPH) activity riboflavin reductase (NADPH) activity FMN reductase (NAD(P)H) activity	pigment catabolic process pigment metabolic process heme metabolic process catabolic process tetrapyrrole metabolic process heme catabolic process porphyrin-containing compound catabolic process metabolic process cellular process porphyrin-containing compound metabolic process tetrapyrrole catabolic process developmental process cellular developmental process myeloid cell differentiation pigment catabolic process pigment metabolic process heme metabolic process catabolic process tetrapyrrole metabolic process heme catabolic process porphyrin-containing compound catabolic process metabolic process cellular process porphyrin-containing compound metabolic process tetrapyrrole catabolic process developmental process cellular developmental process myeloid cell differentiation hemopoiesis cell differentiation anatomical structure development megakaryocyte differentiation cell development cellular response to stimulus cellular response to nitrogen compound regulation of cellular process response to stimulus negative regulation of signaling signaling response to peptide hormone negative regulation of biological process regulation of signal transduction insulin receptor signaling pathway regulation of cellular response to insulin stimulus negative regulation of cell communication cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus response to hormone negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus regulation of signaling regulation of biological process cell surface receptor signaling pathway negative regulation of response to stimulus response to endogenous stimulus regulation of insulin receptor signaling pathway biological regulation response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound negative regulation of signal transduction cellular response to oxygen-containing compound cellular response to chemical stimulus negative regulation of cellular response to insulin stimulus regulation of response to stimulus negative regulation of insulin receptor signaling pathway response to chemical response to insulin regulation of cell communication cellular response to insulin stimulus	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane intracellular organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016040	NAD(P)-binding domain	Domain
A	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A	IPR051606	Polyketide Oxidoreductase-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P30043	esophageal squamous cell carcinoma tuberculosis diabetes mellitus gastric cancer large cell medulloblastoma malignant mesothelioma medulloblastoma ovarian cancer Sjogren syndrome drug-induced liver injury gastric neoplasm lung cancer Malignant neoplasm of stomach osteosarcoma pancreatic ductal adenocarcinoma esophageal squamous cell carcinoma tuberculosis diabetes mellitus gastric cancer large cell medulloblastoma malignant mesothelioma medulloblastoma ovarian cancer Sjogren syndrome drug-induced liver injury gastric neoplasm lung cancer Malignant neoplasm of stomach osteosarcoma pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma hereditary diffuse gastric adenocarcinoma lung carcinoma MALT lymphoma otitis media primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.