1I38

CRYSTAL STRUCTURE OF THE RAT ANDROGEN RECEPTOR LIGAND BINDING DOMAIN T877A MUTANT COMPLEX WITH DIHYDROTESTOSTERONE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1i38a_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Androgen receptor	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hormone_recep_1	e1i38A1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00104	Ligand-binding domain of nuclear hormone receptor (Hormone_recep)	Ligand-binding domain of nuclear hormone receptor	This all helical domain is involved in binding the hormone in these receptors.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ANDROGEN RECEPTOR	binding hormone binding androgen binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA-binding transcription factor activity, RNA polymerase II-specific binding hormone binding androgen binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein binding protein domain specific binding signaling receptor binding POU domain binding transcription factor binding basal transcription machinery binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear androgen receptor binding transcription coregulator binding transcription coactivator binding beta-catenin binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding transcription regulatory region nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding estrogen response element binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity molecular adaptor activity ATPase binding enzyme binding chromatin binding molecular condensate scaffold activity protein-macromolecule adaptor activity steroid binding lipid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding	multicellular organismal process regulation of biological process regulation of penile erection regulation of reproductive process reproductive process multicellular organismal reproductive process biological regulation positive regulation of biological process mating behavior behavior positive regulation of penile erection positive regulation of multicellular organismal process reproductive behavior regulation of multicellular organismal process multicellular organismal process regulation of biological process regulation of penile erection regulation of reproductive process reproductive process multicellular organismal reproductive process biological regulation positive regulation of biological process mating behavior behavior positive regulation of penile erection positive regulation of multicellular organismal process reproductive behavior regulation of multicellular organismal process penile erection copulation positive regulation of reproductive process developmental process epithelial cell differentiation involved in prostate gland development epithelium development reproductive system development cellular developmental process prostate gland development gland development animal organ development urogenital system development tissue development developmental process involved in reproduction epithelial cell differentiation multicellular organism development cell differentiation anatomical structure development reproductive structure development cellular process system development cellular response to stimulus regulation of cellular process intracellular receptor signaling pathway response to stimulus response to lipid signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone androgen receptor signaling pathway signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus cellular response to organic cyclic compound cellular response to chemical stimulus response to chemical cellular response to lipid nuclear receptor-mediated signaling pathway response to ketone response to oxygen-containing compound response to testosterone branching involved in mammary gland duct morphogenesis mammary gland morphogenesis mammary gland development branching morphogenesis of an epithelial tube lateral sprouting from an epithelium tube morphogenesis gland morphogenesis animal organ morphogenesis epithelial tube morphogenesis tube development lateral sprouting involved in mammary gland duct morphogenesis morphogenesis of an epithelium mammary gland duct morphogenesis tissue morphogenesis anatomical structure morphogenesis mammary gland epithelium development morphogenesis of a branching structure morphogenesis of a branching epithelium male sex differentiation sex differentiation sexual reproduction fertilization single fertilization cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of miRNA transcription positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus positive regulation of insulin-like growth factor receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway regulation of signaling regulation of response to stimulus regulation of cell communication positive regulation of signaling cellular response to gonadotropin stimulus response to gonadotropin cellular response to follicle-stimulating hormone stimulus response to follicle-stimulating hormone system process regulation of systemic arterial blood pressure circulatory system process regulation of blood pressure regulation of biological quality blood circulation response to estrogen cellular response to estrogen stimulus negative regulation of signaling negative regulation of biological process regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway protein localization regulation of localization cellular localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane localization regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process multicellular organism growth developmental growth growth muscle hypertrophy striated muscle adaptation muscle adaptation skeletal muscle adaptation striated muscle hypertrophy muscle system process skeletal muscle hypertrophy gonad development male gonad development development of primary male sexual characteristics development of primary sexual characteristics seminiferous tubule development male somatic sex determination sex determination male sex determination somatic sex determination morphogenesis of an epithelial fold regulation of developmental process positive regulation of cell population proliferation positive regulation of developmental process regulation of epithelial cell proliferation involved in prostate gland development epithelial cell proliferation cell population proliferation positive regulation of epithelial cell proliferation epithelial cell proliferation involved in prostate gland development positive regulation of epithelial cell proliferation involved in prostate gland development regulation of cell population proliferation regulation of epithelial cell proliferation regulation of growth regulation of developmental growth response to peptide hormone response to insulin response to nitrogen compound cellular response to testosterone stimulus cellular response to oxygen-containing compound cellular response to ketone anatomical structure formation involved in morphogenesis animal organ formation regulation of cellular component organization cellular component organization plasma membrane organization cellular component organization or biogenesis negative regulation of integrin biosynthetic process integrin biosynthetic process endomembrane system organization membrane organization negative regulation of cellular component organization regulation of integrin biosynthetic process positive regulation of phosphorylation positive regulation of phosphorus metabolic process phosphorylation positive regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorus metabolic process regulation of phosphorylation phosphorus metabolic process organ growth prostate gland growth positive regulation of intracellular estrogen receptor signaling pathway regulation of intracellular signal transduction regulation of intracellular estrogen receptor signaling pathway regulation of intracellular steroid hormone receptor signaling pathway positive regulation of intracellular signal transduction estrogen receptor signaling pathway positive regulation of intracellular steroid hormone receptor signaling pathway mammary gland lobule development mammary gland alveolus development response to estradiol spermatogenesis male gamete generation gamete generation multi-multicellular organism process maternal process involved in female pregnancy tertiary branching involved in mammary gland duct morphogenesis mammary gland branching involved in pregnancy female pregnancy multi-organism reproductive process positive regulation of gene expression positive regulation of cellular component organization positive regulation of integrin biosynthetic process regulation of cell differentiation positive regulation of cell differentiation embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development intracellular signaling cassette MAPK cascade positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of molecular function regulation of molecular function regulation of DNA-binding transcription factor activity prostate gland epithelium morphogenesis prostate gland morphogenesis negative regulation of cell population proliferation negative regulation of epithelial cell proliferation positive regulation of transcription by RNA polymerase II Leydig cell differentiation cellular component biogenesis organelle organization cellular component assembly organelle assembly membraneless organelle assembly cell development cell morphogenesis epithelial cell development epithelial cell morphogenesis positive regulation of MAPK cascade regulation of MAPK cascade regulation of morphogenesis of an epithelium morphogenesis of an epithelial bud regulation of anatomical structure morphogenesis regulation of morphogenesis of a branching structure morphogenesis of embryonic epithelium regulation of animal organ morphogenesis embryonic morphogenesis prostatic bud formation regulation of prostatic bud formation regulation of animal organ formation positive regulation of transcription by RNA polymerase III transcription by RNA polymerase III regulation of transcription by RNA polymerase III male mating behavior male courtship behavior courtship behavior male genitalia morphogenesis genitalia development male anatomical structure morphogenesis male genitalia development genitalia morphogenesis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen cell periphery plasma membrane membrane protein-containing complex somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection cytoplasm membraneless organelle intracellular membraneless organelle chromatin chromosome axon

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A	IPR001103	Androgen receptor	Family
A	IPR050200	Nuclear hormone receptor family NR3 subfamily	Family
A	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.