1I7M
HUMAN S-ADENOSYLMETHIONINE DECARBOXYLASE WITH COVALENTLY BOUND PYRUVOYL GROUP AND COMPLEXED WITH 4-AMIDINOINDAN-1-ONE-2'-AMIDINOHYDRAZONE
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B [auth A] | 3.60.90.10 | Alpha Beta | 4-Layer Sandwich | S-adenosylmethionine decarboxylase | S-adenosylmethionine decarboxylase | CATH (4.3.0) |
D [auth C] | 3.60.90.10 | Alpha Beta | 4-Layer Sandwich | S-adenosylmethionine decarboxylase | S-adenosylmethionine decarboxylase | CATH (4.3.0) |
A [auth B] | 3.30.360.50 | Alpha Beta | 2-Layer Sandwich | Dihydrodipicolinate Reductase | domain 2 | CATH (4.3.0) |
C [auth D] | 3.30.360.50 | Alpha Beta | 2-Layer Sandwich | Dihydrodipicolinate Reductase | domain 2 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
B [auth A], D [auth C] | PF01536 | Adenosylmethionine decarboxylase (SAM_decarbox) | Adenosylmethionine decarboxylase | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
B [auth A], D [auth C] | P17707 | : |
A [auth B], C [auth D] | P17707 | : 
Protein Modification Annotation
Modified Residue(s) | ||
---|---|---|
Chain | Residue(s) | Description |
B [auth A], D [auth C] | MSE | Parent Component: MET |
B [auth A], D [auth C] | PYR | AA0127 :  pyruvic acid (Cys) MOD:00136 , pyruvic acid (Ser) MOD:00807 , pyruvic acid MOD:01154 , pyruvic acid (Tyr) MOD:01661 | : 
A [auth B], C [auth D] | MSE | Parent Component: MET :  AA0127 |