Annotations: 1IFA

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ifaa_	All alpha proteins	4-helical cytokines	4-helical cytokines	Interferons/interleukin-10 (IL-10)	Interferon-beta	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	4-helical cytokines	8043714	3001717	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Interferon	e1ifaA1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: Interferon	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00143	Interferon alpha/beta domain (Interferon)	Interferon alpha/beta domain	Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily,which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	INTERFERON-BETA	protein-containing complex binding binding protein binding type I interferon receptor binding signaling receptor binding cytokine receptor binding molecular function activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	regulation of transforming growth factor beta production multicellular organismal process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process transforming growth factor beta production regulation of transforming growth factor beta production multicellular organismal process regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process transforming growth factor beta production positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process positive regulation of transforming growth factor beta production positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process cellular response to nitrogen compound cellular response to stimulus cellular response to dsRNA response to stimulus cellular response to organic cyclic compound response to dsRNA response to nitrogen compound cellular response to chemical stimulus response to chemical response to organic cyclic compound cell surface receptor signaling pathway signaling response to cytokine cytokine-mediated signaling pathway cell communication response to peptide cellular response to cytokine stimulus signal transduction developmental process cellular developmental process hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation immune system process anatomical structure development leukocyte differentiation immune response adaptive immune response negative regulation of mononuclear cell migration negative regulation of locomotion regulation of cell motility negative regulation of biological process negative regulation of cellular process regulation of cell migration cell migration regulation of immune system process cell motility regulation of mononuclear cell migration negative regulation of cell migration locomotion regulation of leukocyte migration leukocyte migration negative regulation of leukocyte migration negative regulation of immune system process regulation of locomotion mononuclear cell migration negative regulation of cell motility natural killer cell activation cell activation involved in immune response immune effector process natural killer cell activation involved in immune response leukocyte activation involved in immune response lymphocyte activation involved in immune response humoral immune response regulation of immune effector process immunoglobulin production negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process negative regulation of immunoglobulin production production of molecular mediator of immune response negative regulation of metabolic process negative regulation of immune effector process negative regulation of cellular biosynthetic process negative regulation of production of molecular mediator of immune response negative regulation of gene expression regulation of immunoglobulin production negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of production of molecular mediator of immune response response to exogenous dsRNA regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress regulation of neuroinflammatory response negative regulation of defense response inflammatory response negative regulation of neuroinflammatory response neuroinflammatory response myeloid leukocyte differentiation regulation of leukocyte differentiation regulation of developmental process regulation of cell differentiation regulation of cell development regulation of osteoclast differentiation multicellular organism development osteoclast differentiation negative regulation of cell differentiation negative regulation of hemopoiesis regulation of multicellular organismal development negative regulation of leukocyte differentiation regulation of myeloid cell differentiation negative regulation of developmental process regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development myeloid cell differentiation regulation of hemopoiesis negative regulation of multicellular organismal process biological process involved in interspecies interaction between organisms response to other organism response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus response to ketone response to lipid cellular response to endogenous stimulus response to hormone response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus cellular response to hormone stimulus response to endogenous stimulus cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to corticosteroid stimulus response to corticosteroid cellular response to lipid response to dexamethasone regulation of cell adhesion molecule production negative regulation of cell adhesion molecule production cell adhesion molecule production cell population proliferation B cell proliferation leukocyte proliferation mononuclear cell proliferation lymphocyte proliferation macrophage activation involved in immune response myeloid cell activation involved in immune response myeloid leukocyte activation macrophage activation negative regulation of cell population proliferation regulation of cell population proliferation regulation of blood-brain barrier permeability system process maintenance of blood-brain barrier homeostatic process tissue homeostasis regulation of vascular permeability negative regulation of vascular permeability circulatory system process multicellular organismal-level homeostasis vascular process in circulatory system anatomical structure homeostasis regulation of biological quality blood circulation negative regulation of blood-brain barrier permeability regulation of type II interferon production type II interferon production negative regulation of type II interferon production negative regulation of cytokine production T cell activation involved in immune response T cell activation protein localization negative regulation of protein transport regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport matrix metallopeptidase secretion negative regulation of transport protein localization to extracellular region localization secretion by cell negative regulation of secretion regulation of secretion by cell cellular macromolecule localization negative regulation of secretion by cell negative regulation of protein localization regulation of matrix metallopeptidase secretion secretion regulation of transport negative regulation of matrix metallopeptidase secretion establishment of protein localization to extracellular region regulation of establishment of protein localization export from cell negative regulation of establishment of protein localization regulation of protein transport protein secretion establishment of localization regulation of secretion regulation of protein secretion negative regulation of protein secretion protein transport regulation of cellular localization macromolecule localization negative regulation of Lewy body formation regulation of cellular component organization negative regulation of cellular component organization regulation of inclusion body assembly regulation of Lewy body formation inclusion body assembly regulation of cellular component biogenesis Lewy body formation cellular component biogenesis cellular component organization cellular component assembly cellular component organization or biogenesis negative regulation of inclusion body assembly defense response to symbiont defense response to virus response to virus positive regulation of autophagy catabolic process autophagy regulation of catabolic process regulation of autophagy cellular catabolic process positive regulation of catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process process utilizing autophagic mechanism cellular response to virus cellular homeostasis neuron cellular homeostasis positive regulation of phosphorylation regulation of peptidyl-serine phosphorylation regulation of signal transduction positive regulation of phosphate metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification regulation of receptor signaling pathway via JAK-STAT protein modification process phosphorus metabolic process positive regulation of protein phosphorylation positive regulation of peptidyl-serine phosphorylation of STAT protein protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process serine phosphorylation of STAT protein macromolecule modification regulation of phosphorus metabolic process regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation of STAT protein peptidyl-serine modification positive regulation of protein modification process peptidyl-serine phosphorylation protein metabolic process regulation of signaling positive regulation of peptidyl-serine phosphorylation regulation of cell communication regulation of phosphorylation cell surface receptor signaling pathway via JAK-STAT interferon-mediated signaling pathway cellular response to type I interferon innate immune response type I interferon-mediated signaling pathway response to type I interferon	extracellular region cellular anatomical entity extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000471	Interferon alpha/beta/delta	Family
A	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.