Annotations: 1IG8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ig8a1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	Hexokinase	Hexokinase	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Hexokinase	8023103	4000524	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Actin-like ATPases	8035484	3000092	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Actin-like ATPases	8035483	3000092	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hexokinase_1	e1ig8A1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Hexokinase_1	ECOD (1.6)
A	Hexokinase_2	e1ig8A2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Hexokinase_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.1250	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
A	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	3.40.367.20	Alpha Beta	3-Layer(aba) Sandwich	Hexokinase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03727	Hexokinase (Hexokinase_2)	Hexokinase	Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and Pfam:PF00349. Some members of the family have two copies of each of these domains.	Domain
A	PF00349	Hexokinase (Hexokinase_1)	Hexokinase	Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and Pfam:PF03727. Some members of the family have two copies of each of these domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	hexokinase PII	carbohydrate kinase activity kinase activity hexokinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups glucokinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding carbohydrate kinase activity kinase activity hexokinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups glucokinase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding fructokinase activity mannokinase activity D-glucose binding monosaccharide binding carbohydrate binding	cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process metabolic process primary metabolic process fructose metabolic process cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process metabolic process primary metabolic process fructose metabolic process import into cell hexose transmembrane transport transport import across plasma membrane carbohydrate import across plasma membrane carbohydrate transport establishment of localization fructose transmembrane transport hexose import across plasma membrane transmembrane transport localization fructose import across plasma membrane cellular process monosaccharide transmembrane transport carbohydrate transmembrane transport cellular component organization regulation of cellular component size biological regulation cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size organophosphate metabolic process cellular metabolic process phosphate-containing compound metabolic process carbohydrate derivative metabolic process glucose 6-phosphate metabolic process phosphorus metabolic process carbohydrate phosphorylation phosphorylation regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of transcription by glucose regulation of metabolic process glucose metabolic process cellular response to stimulus response to stimulus negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction regulation of programmed cell death negative regulation of cell communication cell communication negative regulation of apoptotic signaling pathway negative regulation of cellular process signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of signal transduction apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process glycolytic process pyridine-containing compound metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy purine-containing compound metabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process mannose metabolic process D-glucose import D-glucose transmembrane transport	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane membrane organelle envelope mitochondrial envelope organelle membrane cytosol membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane membrane organelle envelope mitochondrial envelope organelle membrane cytosol nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A	IPR022673	Hexokinase, C-terminal	Domain
A	IPR019807	Hexokinase, binding site	Binding Site
A	IPR001312	Hexokinase	Family
A	IPR022672	Hexokinase, N-terminal	Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	hexokinase (type II) M-CSA #651	Yeast Hexokinase PII is one of the two isoenzymes present in Saccharomyces cerevisiae which are able to catalyse the phosphorylation of glucose to glucose-6-phosphate. This is the first step in glycolysis, so is of vital importance as it creates an intermediate which can be passed into many other pathways such as glycogen synthesis and the pentose phosphate pathway. 80% sequence identity is observed between the isoenzymes, and both show significant structural identity to the mammalian form of the enzyme, allowing them to be placed together in the same homologous family.	Defined by 3 residues: SER:A-158ARG:A-173ASP:A-211 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 2.7.1.1 (PDB Primary Data) Search M-CSA Motif + EC 2.7.1.1

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.