1IVO

Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1ivob1	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	L domain-like	L domain	EGF receptor extracellular domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1ivob4	Small proteins	Knottins (small inhibitors, toxins, lectins)	Growth factor receptor domain	Growth factor receptor domain	EGF receptor Cys-rich domains, C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1ivob3	Small proteins	Knottins (small inhibitors, toxins, lectins)	Growth factor receptor domain	Growth factor receptor domain	EGF receptor Cys-rich domains, N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1ivob5	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1ivoa1	Alpha and beta proteins (a/b)	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	L domain-like	L domain	EGF receptor extracellular domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1ivoa4	Small proteins	Knottins (small inhibitors, toxins, lectins)	Growth factor receptor domain	Growth factor receptor domain	EGF receptor Cys-rich domains, C-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1ivoa3	Small proteins	Knottins (small inhibitors, toxins, lectins)	Growth factor receptor domain	Growth factor receptor domain	EGF receptor Cys-rich domains, N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1ivoa5	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1ivoc_	Small proteins	Knottins (small inhibitors, toxins, lectins)	EGF/Laminin	EGF-type module	Epidermal growth factor, EGF	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1ivod_	Small proteins	Knottins (small inhibitors, toxins, lectins)	EGF/Laminin	EGF-type module	Epidermal growth factor, EGF	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	L domain-like	8038760	3001010	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Growth factor receptor domain-like	8038763	3000398	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	L domain-like	8038760	3001010	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Growth factor receptor domain-like	8038763	3000398	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	EGF/Laminin-like	8033508	3000412	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	EGF/Laminin-like	8033508	3000412	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Recep_L_domain	e1ivoB1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: Recep_L_domain	ECOD (1.6)
B	GF_recep_IV,Recep_L_domain	e1ivoB3	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: GF_recep_IV,Recep_L_domain	ECOD (1.6)
B	Furin-like	e1ivoB2	A: few secondary structure elements	X: EGF-like	H: Growth factor receptor domain (From Topology)	T: Growth factor receptor domain	F: Furin-like	ECOD (1.6)
A	Recep_L_domain	e1ivoA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: Recep_L_domain	ECOD (1.6)
A	GF_recep_IV,Recep_L_domain	e1ivoA4	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: GF_recep_IV,Recep_L_domain	ECOD (1.6)
A	Furin-like	e1ivoA3	A: few secondary structure elements	X: EGF-like	H: Growth factor receptor domain (From Topology)	T: Growth factor receptor domain	F: Furin-like	ECOD (1.6)
C	EGF	e1ivoC1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: EGF	ECOD (1.6)
D	EGF	e1ivoD1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: EGF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.80.20.20	Alpha Beta	Alpha-Beta Horseshoe	24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'	Chain A	CATH (4.3.0)
B	2.10.220.10	Mainly Beta	Ribbon	Hormone Receptor, Insulin-like Growth Factor Receptor 1	Chain A domain 2	CATH (4.3.0)
A	3.80.20.20	Alpha Beta	Alpha-Beta Horseshoe	24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'	Chain A	CATH (4.3.0)
A	2.10.220.10	Mainly Beta	Ribbon	Hormone Receptor, Insulin-like Growth Factor Receptor 1	Chain A domain 2	CATH (4.3.0)
C	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)
D	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00757	Furin-like cysteine rich region (Furin-like)	Furin-like cysteine rich region	-	Domain
A, B	PF01030	Receptor L domain (Recep_L_domain)	Receptor L domain	-	Repeat
A, B	PF14843	Growth factor receptor domain IV (GF_recep_IV)	Growth factor receptor domain IV	This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030) [1].	Domain
C, D	PF00008	EGF-like domain (EGF)	EGF-like domain	There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is t ...	There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Epidermal Growth Factor Receptor	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding protein phosphatase binding phosphatase binding enzyme binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding protein phosphatase binding phosphatase binding enzyme binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cell adhesion molecule binding cadherin binding calmodulin binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding growth factor binding epidermal growth factor binding hormone binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity protein tyrosine kinase activator activity enzyme regulator activity transmembrane receptor protein tyrosine kinase activator activity molecular function activator activity protein kinase regulator activity signaling receptor activator activity kinase activator activity enzyme activator activity molecular function regulator activity signaling receptor regulator activity protein kinase activator activity kinase regulator activity kinase binding protein kinase binding protein serine/threonine kinase activity MAP kinase kinase kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane receptor protein kinase activity ATPase binding identical protein binding virus receptor activity exogenous protein binding epidermal growth factor receptor activity chromatin binding integrin binding signaling receptor binding DNA binding double-stranded DNA binding nucleic acid binding	developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis salivary gland morphogenesis anatomical structure development animal organ morphogenesis exocrine system development system development regulation of biological process developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis salivary gland morphogenesis anatomical structure development animal organ morphogenesis exocrine system development system development regulation of biological process regulation of cellular process cellular metabolic process reactive oxygen species metabolic process biological regulation positive regulation of biological process regulation of superoxide metabolic process regulation of cellular metabolic process positive regulation of cellular metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process positive regulation of metabolic process superoxide anion generation metabolic process cellular process positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of metabolic process regulation of reactive oxygen species metabolic process positive regulation of cellular process regulation of tube diameter system process regulation of tube size regulation of system process positive regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process regulation of multicellular organismal process blood vessel diameter maintenance regulation of biological quality vasoconstriction blood circulation regulation of anatomical structure size tongue development sensory organ development positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of protein localization localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation macromolecule metabolic process cerebral cortex cell migration head development forebrain development brain development nervous system development pallium development cerebral cortex development telencephalon cell migration central nervous system development forebrain cell migration cell migration telencephalon development cell motility cellular response to stimulus response to stimulus signaling negative regulation of signaling negative regulation of ERBB signaling pathway negative regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cell communication regulation of epidermal growth factor receptor signaling pathway negative regulation of cellular process epidermal growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling regulation of ERBB signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus negative regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway regulation of cell communication regulation of cellular response to stress positive regulation of response to stimulus nucleobase-containing compound metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress regulation of nucleobase-containing compound metabolic process DNA repair positive regulation of nucleobase-containing compound metabolic process DNA metabolic process nucleic acid metabolic process regulation of DNA repair positive regulation of DNA metabolic process DNA damage response regulation of DNA metabolic process positive regulation of macromolecule biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of miRNA metabolic process miRNA metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of miRNA transcription response to nutrient levels response to cobalamin response to chemical response to nutrient response to oxygen-containing compound response to nitrogen compound response to vitamin response to organic cyclic compound cellular developmental process astrocyte differentiation cell development astrocyte activation glial cell development neurogenesis astrocyte development gliogenesis cell differentiation defense response cell activation glial cell differentiation glial cell activation inflammatory response neuroinflammatory response ossification cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation digestive system development tube development digestive tract development tube morphogenesis digestive tract morphogenesis positive regulation of cell communication establishment of protein localization nitrogen compound transport positive regulation of establishment of protein localization regulation of peptide hormone secretion positive regulation of prolactin secretion regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion establishment of localization regulation of secretion regulation of protein secretion regulation of hormone secretion regulation of peptide secretion transport positive regulation of secretion by cell hormone secretion protein localization to extracellular region positive regulation of protein transport peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of peptide secretion secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization prolactin secretion cell-cell signaling export from cell regulation of protein transport positive regulation of protein secretion peptide transport positive regulation of transport protein transport peptide hormone secretion hormone transport positive regulation of signaling cellular response to chemical stimulus cellular response to xenobiotic stimulus response to xenobiotic stimulus ERBB2 signaling pathway ERBB2-EGFR signaling pathway ovulation cycle rhythmic process reproductive process multicellular organismal reproductive process regulation of growth regulation of cellular component organization growth positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular component organization or biogenesis circadian rhythm hydrogen peroxide metabolic process positive regulation of signal transduction intracellular signal transduction positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade modulation of chemical synaptic transmission synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic synaptic signaling trans-synaptic signaling positive regulation of synaptic transmission positive regulation of synaptic transmission, glutamatergic chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death epithelium development epidermis development molting cycle process hair cycle tissue development skin development skin epidermis development hair follicle development molting cycle hair cycle process morphogenesis of an epithelial fold tissue morphogenesis morphogenesis of an epithelium animal organ regeneration liver development regeneration hepaticobiliary system development liver regeneration regulation of catalytic activity regulation of cyclin-dependent protein kinase activity regulation of transferase activity positive regulation of protein serine/threonine kinase activity positive regulation of cyclin-dependent protein serine/threonine kinase activity regulation of cyclin-dependent protein serine/threonine kinase activity cell cycle regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity positive regulation of cyclin-dependent protein kinase activity positive regulation of molecular function positive regulation of protein kinase activity regulation of cell cycle positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity positive regulation of cell cycle placenta development chordate embryonic development embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development regulation of MAP kinase activity positive regulation of MAP kinase activity epithelial cell proliferation response to mechanical stimulus response to external stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction regulation of body fluid levels secretion by tissue regulation of mucus secretion mucus secretion body fluid secretion positive regulation of mucus secretion response to lipid cellular response to organic cyclic compound cellular response to oxygen-containing compound cellular response to lipid response to estradiol cellular response to estradiol stimulus membrane organization establishment of protein localization to membrane protein insertion into membrane regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway eyelid development in camera-type eye eye development visual system development camera-type eye development sensory system development cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to epidermal growth factor stimulus response to epidermal growth factor response to growth factor positive regulation of nervous system development regulation of developmental process regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process regulation of glial cell proliferation positive regulation of cell differentiation positive regulation of neurogenesis regulation of multicellular organismal development positive regulation of cell development glial cell proliferation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction protein autophosphorylation peptidyl-tyrosine modification peptidyl-tyrosine autophosphorylation peptidyl-tyrosine phosphorylation midgut development regulation of JNK cascade JNK cascade response to metal ion response to calcium ion regulation of peptidyl-tyrosine phosphorylation positive regulation of DNA replication DNA replication regulation of DNA replication response to ketone response to hormone response to steroid hormone cellular response to ketone cellular response to steroid hormone stimulus cellular response to hormone stimulus cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to dexamethasone regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition response to light stimulus response to radiation response to UV response to UV-A cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical response to amino acid homeostatic process regulation of bone remodeling tissue homeostasis regulation of tissue remodeling regulation of bone resorption bone resorption multicellular organismal-level homeostasis tissue remodeling bone remodeling anatomical structure homeostasis positive regulation of bone resorption negative regulation of catabolic process catabolic process negative regulation of metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process negative regulation of protein catabolic process regulation of protein catabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process cellular response to metal ion cellular response to cadmium ion response to cadmium ion transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II response to phenylpropanoid response to hydroxyisoflavone translation negative regulation of cell differentiation negative regulation of cardiocyte differentiation heart development negative regulation of developmental process cardiocyte differentiation circulatory system development regulation of cardiocyte differentiation negative regulation of multicellular organismal process fibroblast proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation respiratory tube development lung development respiratory system development positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction diterpenoid metabolic process cellular lipid metabolic process terpenoid metabolic process isoprenoid metabolic process lipid metabolic process cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis plasma membrane bounded cell projection organization generation of neurons neuron development vasodilation cellular response to oxidative stress cellular response to chemical stress response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress behavior learning or memory nervous system process cognition cell adhesion cell-cell adhesion positive regulation of protein kinase C activity regulation of protein kinase C activity negative regulation of cell cycle negative regulation of mitotic cell cycle	membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane intracellular vesicle membrane-bounded organelle intracellular anatomical structure nuclear membrane membrane nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane intracellular vesicle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane cytoplasm protein-containing complex receptor complex Golgi membrane Golgi apparatus endosome membrane endosome extracellular region extracellular space anchoring junction cell junction focal adhesion cell-substrate junction cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane ruffle cell leading edge leading edge membrane plasma membrane bounded cell projection cell projection ruffle membrane cell projection membrane basal part of cell basal plasma membrane cell surface membrane microdomain membrane raft organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane basolateral plasma membrane perinuclear region of cytoplasm Shc-EGFR complex plasma membrane protein complex membrane protein complex multivesicular body, internal vesicle vesicle lumen multivesicular body, internal vesicle lumen membrane-enclosed lumen intracellular organelle lumen organelle lumen late endosome multivesicular body early endosome early endosome membrane
C, D	Epidermal growth factor	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity cation binding ion binding calcium ion binding metal ion binding small molecule binding protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity cation binding ion binding calcium ion binding metal ion binding small molecule binding protein tyrosine kinase activator activity enzyme regulator activity transmembrane receptor protein tyrosine kinase activator activity protein kinase regulator activity kinase activator activity enzyme activator activity protein kinase activator activity kinase regulator activity GTPase regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity epidermal growth factor receptor binding growth factor receptor binding	regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding cellular response to stimulus cell surface receptor signaling pathway via STAT regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding cellular response to stimulus cell surface receptor signaling pathway via STAT regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling regulation of signal transduction cell communication regulation of response to stimulus regulation of receptor signaling pathway via JAK-STAT regulation of cell communication cellular process signal transduction regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT regulation of calcium ion import regulation of calcium ion transport regulation of localization transport regulation of transport regulation of monoatomic ion transport establishment of localization calcium ion transport metal ion transport localization monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport developmental process multicellular organismal process epithelium development tube development branching morphogenesis of an epithelial tube morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis multicellular organism development tube morphogenesis morphogenesis of a branching structure anatomical structure development epithelial tube morphogenesis morphogenesis of a branching epithelium cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process positive regulation of cerebellar granule cell precursor proliferation positive regulation of cell population proliferation regulation of cerebellar granule cell precursor proliferation cell proliferation in external granule layer cell proliferation in hindbrain system development regulation of neural precursor cell proliferation head development cell population proliferation animal organ development brain development nervous system development positive regulation of neural precursor cell proliferation central nervous system development regulation of cell population proliferation cerebellar granule cell precursor proliferation neural precursor cell proliferation hindbrain development secretion negative regulation of biological process negative regulation of transport regulation of secretion negative regulation of secretion positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle cellular component organization regulation of mitotic cell cycle positive regulation of cell cycle process cellular component organization or biogenesis cell cycle regulation of cell cycle cell cycle process mitotic nuclear division regulation of cell cycle process organelle fission positive regulation of nuclear division regulation of organelle organization positive regulation of cell cycle organelle organization nuclear division mitotic cell cycle process regulation of nuclear division cell surface receptor protein tyrosine kinase signaling pathway ERBB signaling pathway epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway negative regulation of sterol transport regulation of lipid transport organic hydroxy compound transport negative regulation of lipid localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport regulation of sterol transport negative regulation of lipid transport lipid localization lipid transport negative regulation of cholesterol transport regulation of lipid localization negative regulation of cholesterol efflux macromolecule localization cholesterol transport cholesterol efflux ERBB2 signaling pathway ERBB2-EGFR signaling pathway mucopolysaccharide metabolic process glycosaminoglycan metabolic process regulation of hyaluronan biosynthetic process carbohydrate derivative metabolic process regulation of polysaccharide metabolic process regulation of primary metabolic process hyaluronan metabolic process polysaccharide metabolic process positive regulation of hyaluronan biosynthetic process glycosaminoglycan biosynthetic process regulation of carbohydrate metabolic process carbohydrate derivative biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process primary metabolic process hyaluronan biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan metabolic process aminoglycan biosynthetic process positive regulation of carbohydrate metabolic process regulation of carbohydrate biosynthetic process positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion blood vessel morphogenesis angiogenesis vasculature development circulatory system development anatomical structure formation involved in morphogenesis blood vessel development positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-threonine phosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification protein metabolic process peptidyl-threonine modification positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-threonine phosphorylation phosphorylation regulation of protein metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation peptidyl-threonine phosphorylation catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis protein catabolic process regulation of catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process modification-dependent protein catabolic process positive regulation of proteolysis ubiquitin-dependent protein catabolic process intracellular signal transduction intracellular signaling cassette MAPK cascade ERK1 and ERK2 cascade import into cell receptor internalization regulation of receptor internalization vesicle-mediated transport positive regulation of endocytosis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport positive regulation of receptor internalization positive regulation of transport endocytosis receptor-mediated endocytosis protein localization cellular localization regulation of protein localization protein localization to cell surface regulation of cellular localization cellular macromolecule localization regulation of protein localization to cell surface positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling positive regulation of epithelial tube formation regulation of developmental process tube formation positive regulation of developmental process epithelial tube formation positive regulation of morphogenesis of an epithelium regulation of morphogenesis of an epithelium regulation of multicellular organismal process regulation of epithelial tube formation regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of multicellular organismal process positive regulation of protein localization to early endosome protein localization to endosome protein localization to early endosome regulation of protein localization to endosome protein localization to organelle positive regulation of protein localization positive regulation of protein localization to endosome regulation of protein localization to early endosome positive regulation of MAPK cascade regulation of MAPK cascade epithelial cell proliferation positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation mammary gland development gland development mammary gland lobule development mammary gland alveolus development peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation	membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane membrane cellular anatomical entity intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome vesicle lumen membrane-enclosed lumen cytoplasmic vesicle lumen secretory granule lumen endomembrane system intracellular organelle lumen organelle lumen secretory granule secretory vesicle platelet alpha granule platelet alpha granule lumen cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor	Family
A, B	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR000719	Protein kinase domain	Domain
A, B	IPR032778	Growth factor receptor domain 4	Domain
A, B	IPR006212	Furin-like repeat	Repeat
A, B	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A, B	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B	IPR036941	Receptor L-domain superfamily	Homologous Superfamily
A, B	IPR049328	Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment	Domain
A, B	IPR000494	Receptor L-domain	Domain
A, B	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B	IPR006211	Furin-like cysteine-rich domain	Domain
A, B	IPR050122	Receptor Tyrosine Kinase	Family
C, D	IPR018097	EGF-like calcium-binding, conserved site	Conserved Site
C, D	IPR049883	NOTCH1 EGF-like calcium-binding domain	Domain
C, D	IPR000033	LDLR class B repeat	Repeat
C, D	IPR001881	EGF-like calcium-binding domain	Domain
C, D	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
C, D	IPR000742	EGF-like domain	Domain
C, D	IPR050778	Cueball/EGF/LRP/Nidogen	Family
C, D	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
C, D	IPR016317	Pro-epidermal growth factor	Family
C, D	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P00533	glioblastoma non-small cell lung carcinoma inflammatory skin and bowel disease, neonatal, 2 giant cell glioblastoma osteosarcoma lung cancer cholangiocarcinoma squamous cell carcinoma autosomal recessive polycystic kidney disease dilated cardiomyopathy breast cancer cancer esophageal squamous cell carcinoma classic familial adenomatous polyposis gliosarcoma glioblastoma non-small cell lung carcinoma inflammatory skin and bowel disease, neonatal, 2 giant cell glioblastoma osteosarcoma lung cancer cholangiocarcinoma squamous cell carcinoma autosomal recessive polycystic kidney disease dilated cardiomyopathy breast cancer cancer esophageal squamous cell carcinoma classic familial adenomatous polyposis gliosarcoma breast carcinoma malignant colon neoplasm ovarian cancer papilloma urinary bladder cancer adrenal cortex carcinoma head and neck cancer squamous papilloma head and neck squamous cell carcinoma tubular adenocarcinoma dermatitis prostate cancer Mammary Neoplasms, Experimental adenocarcinoma rectal cancer cervical cancer small cell lung carcinoma colorectal cancer malignant mesothelioma bile duct cancer type 2 diabetes mellitus intrahepatic cholangiocarcinoma gallbladder cancer granular cell carcinoma bile duct carcinoma endometriosis rectal neoplasm carcinoma esophageal cancer sarcomatoid carcinoma nasopharyngeal carcinoma malignant glioma cribriform carcinoma ovarian disease benign neoplasm of esophagus pancreatic ductal adenocarcinoma papillomatosis hepatocellular carcinoma bile duct neoplasm malignant pancreatic neoplasm pituitary cancer brain disease urinary bladder disease acute kidney failure interstitial cystitis uterine disease endometrial carcinoma kidney disease maturity-onset diabetes of the young endometrium adenocarcinoma rheumatoid arthritis laryngeal squamous cell carcinoma carcinoma of esophagus lung benign neoplasm nasopharyngeal neoplasm lung disease neoplasm of esophagus gastric cancer major depressive disorder atypical teratoid rhabdoid tumor squamous cell lung carcinoma Cowden syndrome 1 head and neck carcinoma benign colon neoplasm subependymal giant cell astrocytoma cribriform carcinoma of breast ovarian neoplasm pancreatic neoplasm Pick disease bone disease malignant tumor of nasopharynx dilated cardiomyopathy 1A brain glioma urinary bladder neoplasm ductal breast carcinoma in situ prostate disease rectal carcinoma medulloblastoma endometrium carcinoma in situ adrenal carcinoma sarcoidosis myopathy esophagus carcinoma in situ alcohol abuse small cell carcinoma gastric neoplasm spina bifida colonic neoplasm neoplasm of neck colorectal carcinoma autosomal dominant polycystic kidney disease head and neck neoplasm benign mesothelioma tongue squamous cell carcinoma cutaneous lupus erythematosus pancreatic adenocarcinoma hematologic disease undifferentiated carcinoma digestive system disease pilocytic astrocytoma hereditary diffuse gastric adenocarcinoma bone osteosarcoma malignant tumor of neck prostate adenocarcinoma mammary neoplasms, animal invasive ductal breast carcinoma breast disease large cell medulloblastoma mesothelioma lung adenocarcinoma exanthem lung carcinoma gallbladder neoplasm genetic intestinal polyposis lymphatic system disease colorectal adenocarcinoma glioma astrocytic tumor oligodendroglioma
C, D	Pharos: P01133	renal hypomagnesemia 4 glioblastoma kidney disease cleft palate Metaplasia giant cell glioblastoma adenocarcinoma breast carcinoma pulmonary fibrosis dermatitis juvenile idiopathic arthritis gastric ulcer granular cell carcinoma hepatocellular carcinoma prostate cancer renal hypomagnesemia 4 glioblastoma kidney disease cleft palate Metaplasia giant cell glioblastoma adenocarcinoma breast carcinoma pulmonary fibrosis dermatitis juvenile idiopathic arthritis gastric ulcer granular cell carcinoma hepatocellular carcinoma prostate cancer breast cancer tubular adenocarcinoma gastric cancer pancreatic ductal adenocarcinoma idiopathic interstitial pneumonia pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adult hepatocellular carcinoma precancerous condition prostate disease stomach disease lung disease exocrine pancreatic carcinoma gastric carcinoma osteosarcoma hematologic disease pancreatic intraductal papillary-mucinous carcinoma inherited disease susceptibility peripheral nervous system disease intestinal disease bone disease breast disease schizophrenia liver disease cribriform carcinoma major depressive disorder malignant pancreatic neoplasm familial primary hypomagnesemia with normocalciuria and normocalcemia melanoma ovarian disease pancreatic intraductal papillary-mucinous neoplasm injury peripheral neuropathy autism ischemia reperfusion injury psoriasis cancer skin disease lung adenocarcinoma cribriform carcinoma of breast malignant mesothelioma