1JBH

Solution structure of cellular retinol binding protein type-I in the ligand-free state

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1jbha_	All beta proteins	Lipocalins	Lipocalins	Fatty acid binding protein-like	Cellular retinol-binding protein II (CRBP)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Fatty acid binding protein-like	8062818	4002547	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Lipocalins	8062819	3001332	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lipocalin_7	e1jbhA1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00061	Lipocalin / cytosolic fatty-acid binding protein family (Lipocalin)	Lipocalin / cytosolic fatty-acid binding protein family	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid ...	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CELLULAR RETINOL-BINDING PROTEIN TYPE I	vitamin binding binding retinal binding isoprenoid binding retinoid binding lipid binding small molecule binding fatty acid binding organic acid binding ion binding anion binding carboxylic acid binding monocarboxylic acid binding alcohol binding vitamin binding binding retinal binding isoprenoid binding retinoid binding lipid binding small molecule binding fatty acid binding organic acid binding ion binding anion binding carboxylic acid binding monocarboxylic acid binding alcohol binding retinol binding all-trans-retinol binding	organic anion transport carboxylic acid transport transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport macromolecule localization response to stimulus response to chemical response to benzoic acid organic anion transport carboxylic acid transport transport lipid localization lipid transport establishment of localization organic acid transport localization monocarboxylic acid transport fatty acid transport macromolecule localization response to stimulus response to chemical response to benzoic acid response to oxygen-containing compound response to organic cyclic compound diterpenoid metabolic process oxoacid metabolic process regulation of hormone levels biological regulation carboxylic acid metabolic process primary metabolic process organic acid metabolic process hormone metabolic process retinoic acid metabolic process retinoid metabolic process metabolic process cellular process small molecule metabolic process regulation of biological quality monocarboxylic acid metabolic process terpenoid metabolic process isoprenoid metabolic process lipid metabolic process chemical homeostasis homeostatic process lipid homeostasis myeloid leukocyte differentiation regulation of leukocyte differentiation multicellular organismal process regulation of granulocyte differentiation regulation of cellular process cellular developmental process regulation of developmental process cell development regulation of cell differentiation regulation of cell development multicellular organism development cell differentiation anatomical structure development regulation of immune system process regulation of multicellular organismal process developmental process regulation of biological process regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation granulocyte differentiation myeloid cell differentiation immune system process regulation of hemopoiesis leukocyte differentiation response to nutrient levels response to lipid response to nutrient response to vitamin A response to vitamin lipid biosynthetic process organic acid biosynthetic process terpenoid biosynthetic process carboxylic acid biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process isoprenoid biosynthetic process diterpenoid biosynthetic process retinoic acid biosynthetic process biosynthetic process response to retinoic acid fat-soluble vitamin metabolic process vitamin A metabolic process vitamin metabolic process organic hydroxy compound metabolic process alcohol metabolic process olefinic compound metabolic process retinol metabolic process primary alcohol metabolic process	lipid droplet intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle cytoplasm cytosol cell body membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle lipid droplet intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle cytoplasm cytosol cell body membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000463	Cytosolic fatty-acid binding	Domain
A	IPR031264	Retinol-binding protein 1	Family
A	IPR012674	Calycin	Homologous Superfamily
A	IPR031259	Intracellular lipid binding protein	Family
A	IPR000566	Lipocalin/cytosolic fatty-acid binding domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.