1JG5

CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1jg5a_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1jg5b_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d1jg5c_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1jg5d_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
E	d1jg5e_	Alpha and beta proteins (a+b)	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	GTP cyclohydrolase I feedback regulatory protein, GFRP	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	GTP cyclohydrolase I feedback regulatory protein, GFRP	8024620	4003468	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8036999	3000919	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8036999	3000919	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8036999	3000919	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8036999	3000919	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GTP cyclohydrolase I feedback regulatory protein, GFRP	8036999	3000919	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GFRP	e1jg5A1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
B	GFRP	e1jg5B1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
C	GFRP	e1jg5C1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
D	GFRP	e1jg5D1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)
E	GFRP	e1jg5E1	A: a+b two layers	X: Glucose permease domain IIB-like	H: GTP cyclohydrolase I feedback regulatory protein, GFRP (From Topology)	T: GTP cyclohydrolase I feedback regulatory protein, GFRP	F: GFRP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1410.10	Alpha Beta	2-Layer Sandwich	Gtp Cyclohydrolase I Feedback Regulatory Protein	Chain: K	CATH (4.3.0)
B	3.30.1410.10	Alpha Beta	2-Layer Sandwich	Gtp Cyclohydrolase I Feedback Regulatory Protein	Chain: K	CATH (4.3.0)
C	3.30.1410.10	Alpha Beta	2-Layer Sandwich	Gtp Cyclohydrolase I Feedback Regulatory Protein	Chain: K	CATH (4.3.0)
D	3.30.1410.10	Alpha Beta	2-Layer Sandwich	Gtp Cyclohydrolase I Feedback Regulatory Protein	Chain: K	CATH (4.3.0)
E	3.30.1410.10	Alpha Beta	2-Layer Sandwich	Gtp Cyclohydrolase I Feedback Regulatory Protein	Chain: K	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF06399	GTP cyclohydrolase I feedback regulatory protein (GFRP) (GFRP)	GTP cyclohydrolase I feedback regulatory protein (GFRP)	Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I f ...	Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis in via feedback inhibition of GTP cyclohydrolase I. This mechanism is mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein (GFRP) [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN	GTP-dependent protein binding protein binding binding protein-containing complex binding enzyme regulator activity molecular function inhibitor activity molecular function regulator activity enzyme inhibitor activity GTP cyclohydrolase binding enzyme binding amino acid binding identical protein binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of biosynthetic process regulation of biological process regulation of cellular process negative regulation of metabolic process biological regulation negative regulation of biological process biosynthetic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of biosynthetic process regulation of biological process regulation of cellular process negative regulation of metabolic process biological regulation negative regulation of biological process biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process metabolic process regulation of metabolic process regulation of nitric oxide biosynthetic process reactive nitrogen species metabolic process nitric oxide metabolic process nitric oxide biosynthetic process regulation of nitric oxide metabolic process	membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle nuclear membrane membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle nuclear membrane membrane nucleus endomembrane system organelle envelope nuclear envelope organelle membrane cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR036717	GFRP superfamily	Homologous Superfamily
A, B, C, D, E	IPR009112	GTP cyclohydrolase I, feedback regulatory protein	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.