1KAC

KNOB DOMAIN FROM ADENOVIRUS SEROTYPE 12 IN COMPLEX WITH DOMAIN 1 OF ITS CELLULAR RECEPTOR CAR

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1kaca_	All beta proteins	Virus attachment protein globular domain	Virus attachment protein globular domain	Adenovirus fiber protein 'knob' domain	Adenovirus fiber protein 'knob' domain	(Human adenovirus 12 ) [TaxId: 28282 ],	SCOPe (2.08)
B	d1kacb_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Coxsackie virus and adenovirus receptor (Car), domain 1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Adenovirus fiber protein knob domain	8028834	4002523	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Virus attachment protein globular domain	8041213	3001376	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054475	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Adeno_knob	e1kacA1	A: beta sandwiches	X: Domain in virus attachment proteins (From Topology)	H: Domain in virus attachment proteins (From Topology)	T: Domain in virus attachment proteins	F: Adeno_knob	ECOD (1.6)
B	I-set_7	e1kacB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_7	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.90.10	Mainly Beta	Sandwich	Adenovirus Type 5 Fiber Protein (Receptor Binding Domain)	Adenovirus pIV-related, attachment domain	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00541	Adenoviral fibre protein (knob domain) (Adeno_knob)	Adenoviral fibre protein (knob domain)	Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal kn ...	Specific attachment of adenovirus is achieved through interactions between host-cell receptors and the adenovirus fibre protein and is mediated by the globular carboxy-terminal domain of the adenovirus fibre protein, termed the carboxy-terminal knob domain.	Domain
B	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN (FIBER KNOB PROTEIN)	-	virion attachment to host cell biological process involved in interspecies interaction between organisms receptor-mediated virion attachment to host cell adhesion of symbiont to host cell viral process viral life cycle adhesion of symbiont to host adhesion receptor-mediated virion attachment to host cell biological process involved in interaction with host biological process involved in symbiotic interaction cell adhesion cellular process symbiont entry into host cell symbiont entry into host	viral capsid virion component host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical structure host cell part host intracellular region host cell nucleus host intracellular organelle
B	PROTEIN (COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR)	cell adhesion molecule binding protein binding binding cell adhesion mediator activity cell adhesive protein binding involved in AV node cell-bundle of His cell communication cell-cell adhesion mediator activity protein binding involved in heterotypic cell-cell adhesion identical protein binding virus receptor activity exogenous protein binding signaling receptor binding PDZ domain binding protein domain specific binding protein-containing complex binding cell adhesion molecule binding protein binding binding cell adhesion mediator activity cell adhesive protein binding involved in AV node cell-bundle of His cell communication cell-cell adhesion mediator activity protein binding involved in heterotypic cell-cell adhesion identical protein binding virus receptor activity exogenous protein binding signaling receptor binding PDZ domain binding protein domain specific binding protein-containing complex binding integrin binding beta-catenin binding connexin binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development heart process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development heart process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation cell communication circulatory system process regulation of blood circulation AV node cell to bundle of His cell communication cardiac conduction cellular process regulation of multicellular organismal process cell communication involved in cardiac conduction heart contraction blood circulation gamma-delta T cell activation T cell activation immune system process cell activation lymphocyte activation leukocyte activation cell chemotaxis cellular response to stimulus chemotaxis response to stimulus neutrophil chemotaxis response to external stimulus neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion regulation of AV node cell action potential AV node cell action potential regulation of cellular process signaling cell-cell signaling involved in cardiac conduction regulation of cardiac muscle cell action potential regulation of biological quality regulation of action potential AV node cell to bundle of His cell signaling cell-cell signaling action potential regulation of cell communication cardiac muscle cell action potential regulation of membrane potential heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization homotypic cell-cell adhesion heterotypic cell-cell adhesion AV node cell-bundle of His cell adhesion involved in cell communication cardiac muscle cell-cardiac muscle cell adhesion biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus sexual reproduction reproductive process multicellular organismal reproductive process germ cell migration gamete generation localization transepithelial transport transport establishment of localization cardiac muscle cell development cellular developmental process cell development muscle cell differentiation striated muscle tissue development muscle structure development striated muscle cell development muscle cell development cell differentiation cardiac cell development muscle tissue development cardiac muscle tissue development cardiac muscle cell differentiation tissue development cardiocyte differentiation striated muscle cell differentiation mitochondrion organization multicellular organismal-level homeostasis epithelial structure maintenance homeostatic process anatomical structure homeostasis tissue homeostasis cell junction organization cell-cell junction organization	cell-cell junction cellular anatomical structure anchoring junction cell junction cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane intracellular anatomical structure cytoplasm cell projection cell-cell junction cellular anatomical structure anchoring junction cell junction cell periphery basal part of cell membrane plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane intracellular anatomical structure cytoplasm cell projection neuron projection plasma membrane bounded cell projection adherens junction neuromuscular junction synapse cell body intercalated disc cell-cell contact zone extracellular region extracellular space actin-based cell projection filopodium acrosomal vesicle membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle vesicle membrane microdomain membrane raft growth cone axon distal axon site of polarized growth apicolateral plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex apical junction complex bicellular tight junction tight junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009013	Attachment protein shaft domain superfamily	Homologous Superfamily
A	IPR000978	Adenoviral fibre protein, knob	Domain
A	IPR008982	Adenovirus pIV-like, attachment domain	Homologous Superfamily
A	IPR000931	Adenovirus fibre protein	Family
A	IPR000939	Adenoviral fibre protein, repeat/shaft region	Repeat
B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B	IPR013106	Immunoglobulin V-set domain	Domain
B	IPR003599	Immunoglobulin domain subtype	Domain
B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR052307	Epithelial Junction Adhesion Regulator	Family
B	IPR003598	Immunoglobulin subtype 2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P78310	Liver Cirrhosis, Experimental pancreatic intraductal papillary-mucinous neoplasm psoriasis astrocytic tumor chronic kidney disease ductal breast carcinoma in situ glioblastoma large cell medulloblastoma malignant ependymoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome atypical teratoid rhabdoid tumor cutaneous lupus erythematosus facioscapulohumeral muscular dystrophy Liver Cirrhosis, Experimental pancreatic intraductal papillary-mucinous neoplasm psoriasis astrocytic tumor chronic kidney disease ductal breast carcinoma in situ glioblastoma large cell medulloblastoma malignant ependymoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome atypical teratoid rhabdoid tumor cutaneous lupus erythematosus facioscapulohumeral muscular dystrophy interstitial cystitis medulloblastoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor spina bifida breast cancer diabetes mellitus gastric carcinoma interstitial lung disease lung cancer non-small cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.