1KL9

Crystal structure of the N-terminal segment of Human eukaryotic initiation factor 2alpha

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1kl9a1	All alpha proteins	SAM domain-like	eIF2alpha middle domain-like	eIF2alpha middle domain-like	Eukaryotic initiation factor 2alpha, eIF2alpha, domain 2	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1kl9a2	All beta proteins	OB-fold	Nucleic acid-binding proteins	Cold shock DNA-binding domain-like	Eukaryotic initiation factor 2alpha, eIF2alpha, N-terminal domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nucleic acid-binding proteins	8042151	3000135	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	eIF2alpha middle domain-like	8042150	3001761	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	S1_1	e1kl9A1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: S1_1	ECOD (1.6)
A	EIF_2_alpha_N	e1kl9A2	A: alpha arrays	X: HhH/H2TH	H: eIF2alpha middle domain (From Topology)	T: eIF2alpha middle domain	F: EIF_2_alpha_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.50.140	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)	Nucleic acid-binding proteins	CATH (4.3.0)
A	1.10.150.190	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07541	Eukaryotic translation initiation factor 2 alpha subunit (EIF_2_alpha)	Eukaryotic translation initiation factor 2 alpha subunit	-	Family
A	PF00575	S1 RNA binding domain (S1)	S1 RNA binding domain	The S1 domain occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein which binds nucleic acids. The S1 domain has an OB-fold structure.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1	translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding nucleic acid binding translation initiation factor activity translation factor activity, RNA binding RNA binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding	cellular response to stimulus cellular response to metal ion response to manganese-induced endoplasmic reticulum stress response to stimulus cellular response to manganese ion cellular response to chemical stress cellular response to chemical stimulus cellular response to stress response to metal ion response to stress response to chemical cellular process response to manganese ion response to endoplasmic reticulum stress cellular response to stimulus cellular response to metal ion response to manganese-induced endoplasmic reticulum stress response to stimulus cellular response to manganese ion cellular response to chemical stress cellular response to chemical stimulus cellular response to stress response to metal ion response to stress response to chemical cellular process response to manganese ion response to endoplasmic reticulum stress cellular biosynthetic process cellular metabolic process primary metabolic process translation gene expression macromolecule biosynthetic process biosynthetic process translational initiation metabolic process protein metabolic process macromolecule metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of translational initiation in response to stress regulation of biosynthetic process regulation of biological process regulation of translational initiation regulation of protein metabolic process negative regulation of metabolic process biological regulation negative regulation of translational initiation regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process cellular response to heat response to heat response to abiotic stimulus response to temperature stimulus regulation of translation in response to stress regulation of translational initiation in response to stress regulation of translation in response to endoplasmic reticulum stress positive regulation of epithelial cell apoptotic process positive regulation of programmed cell death regulation of epithelial cell apoptotic process regulation of type B pancreatic cell apoptotic process regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process epithelial cell apoptotic process positive regulation of type B pancreatic cell apoptotic process type B pancreatic cell apoptotic process apoptotic process programmed cell death positive regulation of cellular process response to oxidative stress cellular response to oxidative stress cellular response to topologically incorrect protein signaling PERK-mediated unfolded protein response endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein intracellular signal transduction integrated stress response signaling cell communication response to topologically incorrect protein intracellular signaling cassette ER-nucleus signaling pathway signal transduction response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation cellular response to abiotic stimulus cellular response to UV response to acid chemical response to kainic acid response to oxygen-containing compound response to nitrogen compound response to amino acid response to organic cyclic compound cellular component biogenesis cellular component organization organelle organization cellular component assembly stress granule assembly organelle assembly non-membrane-bounded organelle assembly cellular component organization or biogenesis response to nutrient levels cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels response to amino acid starvation response to starvation cellular catabolic process mitophagy catabolic process macroautophagy autophagy autophagy of mitochondrion process utilizing autophagic mechanism HRI-mediated signaling	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytoplasmic ribonucleoprotein granule ribonucleoprotein granule intracellular non-membrane-bounded organelle supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol protein-containing complex eukaryotic translation initiation factor 2 complex ribonucleoprotein complex translation initiation ternary complex glial cell projection cell projection glial limiting end-foot plasma membrane bounded cell projection astrocyte end-foot astrocyte projection synapse cell junction translation preinitiation complex eukaryotic 48S preinitiation complex nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR044126	IF2a, S1-like domain	Domain
A	IPR024054	Translation initiation factor 2, alpha subunit, middle domain superfamily	Homologous Superfamily
A	IPR024055	Translation initiation factor 2, alpha subunit, C-terminal	Homologous Superfamily
A	IPR003029	S1 domain	Domain
A	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
A	IPR011488	Translation initiation factor 2, alpha subunit	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P05198	osteosarcoma status epilepticus Alzheimer disease Cognition Disorders ovarian cancer lung cancer psoriasis gastric cancer hepatocellular carcinoma malignant pancreatic neoplasm plasma cell myeloma schizophrenia breast cancer exocrine pancreatic carcinoma gastric carcinoma osteosarcoma status epilepticus Alzheimer disease Cognition Disorders ovarian cancer lung cancer psoriasis gastric cancer hepatocellular carcinoma malignant pancreatic neoplasm plasma cell myeloma schizophrenia breast cancer exocrine pancreatic carcinoma gastric carcinoma IgA glomerulonephritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.