1KPI

Crystal Structure of mycolic acid cyclopropane synthase CmaA2 complexed with SAH and DDDMAB

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1kpia_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	Mycolic acid cyclopropane synthase	CmaA2	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Mycolic acid cyclopropane synthase	8025961	4003320	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8038340	3000118	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CMAS	e1kpiA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: CMAS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2	cyclopropane-fatty-acyl-phospholipid synthase activity transferase activity, transferring one-carbon groups transferase activity methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity catalytic activity	oxoacid metabolic process cellular biosynthetic process cell wall organization or biogenesis lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process cellular component biogenesis mycolic acid biosynthetic process Actinobacterium-type cell wall biogenesis small molecule metabolic process cellular component organization or biogenesis peptidoglycan-based cell wall biogenesis fatty acid metabolic process oxoacid metabolic process cellular biosynthetic process cell wall organization or biogenesis lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process cellular component biogenesis mycolic acid biosynthetic process Actinobacterium-type cell wall biogenesis small molecule metabolic process cellular component organization or biogenesis peptidoglycan-based cell wall biogenesis fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process mycolic acid metabolic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process macromolecule biosynthetic process cell wall biogenesis biosynthetic process cell wall macromolecule biosynthetic process cellular lipid metabolic process cellular process metabolic process macromolecule metabolic process monocarboxylic acid metabolic process lipid metabolic process response to decreased oxygen levels response to stimulus response to hypoxia response to stress response to oxygen levels response to abiotic stimulus methylation S-adenosylmethionine metabolic process sulfur compound metabolic process mycolate cell wall layer assembly cellular component organization cellular component assembly symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host process response to host immune response symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus modulation of process of another organism	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A	IPR047672	Cyclopropane mycolic acid synthase, actinobacteria	Family
A	IPR050723	Cyclopropane Fatty Acid Synthase/Methyltransferase	Family
A	IPR003333	Cyclopropane mycolic acid synthase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.