Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyMHC antigen-recognition domain 8029054 4001031 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyMHC antigen-recognition domain 8041433 3000521 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyMHC antigen-recognition domain 8041433 3000521 SCOP2B (2022-06-29)
CSCOP2 FamilyGLA-domain 8029058 4003544 SCOP2 (2022-06-29)
CSCOP2 SuperfamilyGLA-domain 8041437 3001028 SCOP2 (2022-06-29)
DSCOP2B SuperfamilyGLA-domain 8041437 3001028 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMHC_Ie1lqvA1 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_IECOD (1.6)
BMHC_Ie1lqvB1 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_IECOD (1.6)
CGlae1lqvC1 A: few secondary structure elementsX: GLA-domain (From Topology)H: GLA-domain (From Topology)T: GLA-domainF: GlaECOD (1.6)
DGlae1lqvD1 A: few secondary structure elementsX: GLA-domain (From Topology)H: GLA-domain (From Topology)T: GLA-domainF: GlaECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A, B
PROCR (protein C receptor endothelial, EPCR) G-ALPHA1-ALPHA2-LIKE Homo sapiens (human) EPCR*01 G-DOMAIN G-ALPHA1-LIKE, G-DOMAIN G-ALPHA2-LIKE RPI MH1LIKE-ALPHA-LIKE[2D] IMGT (202445-0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
C, D
PF00594Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (Gla)Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domainThis domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Endothelial protein C receptor
C, D
Vitamin-K dependent protein C

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B
PharosQ9UNN8
C, D
PharosP04070

Membrane Protein Annotation: OPM OPM Database Homepage

ChainsExternal LinkTypeClassSuperfamilyFamily
A, B, C, D
OPMGLA-domain

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
C, D
CGU Parent Component: GLU

RESIDAA0032

PSI-MOD :  L-gamma-carboxyglutamic acid MOD:00041