1LQV
Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C.
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
- Membrane Protein Annotation: OPM
- Protein Modification Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1lqva_ | Alpha and beta proteins (a+b) | MHC antigen-recognition domain | MHC antigen-recognition domain | MHC antigen-recognition domain | Endothelial protein C receptor | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d1lqvb_ | Alpha and beta proteins (a+b) | MHC antigen-recognition domain | MHC antigen-recognition domain | MHC antigen-recognition domain | Endothelial protein C receptor | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
C | d1lqvc_ | Small proteins | GLA-domain | GLA-domain | GLA-domain | Coagulation factor XIV (Protein C) | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
D | d1lqvd_ | Small proteins | GLA-domain | GLA-domain | GLA-domain | Coagulation factor XIV (Protein C) | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2 Family | MHC antigen-recognition domain | 8029054 | 4001031 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | MHC antigen-recognition domain | 8041433 | 3000521 | SCOP2 (2022-06-29) |
B | SCOP2B Superfamily | MHC antigen-recognition domain | 8041433 | 3000521 | SCOP2B (2022-06-29) |
C | SCOP2 Family | GLA-domain | 8029058 | 4003544 | SCOP2 (2022-06-29) |
C | SCOP2 Superfamily | GLA-domain | 8041437 | 3001028 | SCOP2 (2022-06-29) |
D | SCOP2B Superfamily | GLA-domain | 8041437 | 3001028 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | MHC_I | e1lqvA1 | A: a+b two layers | X: MHC antigen-recognition domain (From Topology) | H: MHC antigen-recognition domain (From Topology) | T: MHC antigen-recognition domain | F: MHC_I | ECOD (1.6) |
B | MHC_I | e1lqvB1 | A: a+b two layers | X: MHC antigen-recognition domain (From Topology) | H: MHC antigen-recognition domain (From Topology) | T: MHC antigen-recognition domain | F: MHC_I | ECOD (1.6) |
C | Gla | e1lqvC1 | A: few secondary structure elements | X: GLA-domain (From Topology) | H: GLA-domain (From Topology) | T: GLA-domain | F: Gla | ECOD (1.6) |
D | Gla | e1lqvD1 | A: few secondary structure elements | X: GLA-domain (From Topology) | H: GLA-domain (From Topology) | T: GLA-domain | F: Gla | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.30.500.10 | Alpha Beta | 2-Layer Sandwich | Murine Class I Major Histocompatibility Complex, H2-DB | Chain A, domain 1 | CATH (4.3.0) |
B | 3.30.500.10 | Alpha Beta | 2-Layer Sandwich | Murine Class I Major Histocompatibility Complex, H2-DB | Chain A, domain 1 | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
PROCR (protein C receptor endothelial, EPCR) | G-ALPHA1-ALPHA2-LIKE | Homo sapiens (human) | EPCR*01 | G-DOMAIN G-ALPHA1-LIKE, G-DOMAIN G-ALPHA2-LIKE | RPI | MH1LIKE-ALPHA-LIKE[2D] | IMGT (202443-0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00594 | Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (Gla) | Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain | This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla). | Domain |