1MJQ

METHIONINE REPRESSOR MUTANT (Q44K) PLUS COREPRESSOR (S-ADENOSYL METHIONINE) COMPLEXED TO AN ALTERED MET CONSENSUS OPERATOR SEQUENCE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth A]	d1mjqa_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Met repressor, MetJ (MetR)	Met repressor, MetJ (MetR)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F [auth B]	d1mjqb_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Met repressor, MetJ (MetR)	Met repressor, MetJ (MetR)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G [auth C]	d1mjqc_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Met repressor, MetJ (MetR)	Met repressor, MetJ (MetR)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
H [auth D]	d1mjqd_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Met repressor, MetJ (MetR)	Met repressor, MetJ (MetR)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
I [auth G]	d1mjqg_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Met repressor, MetJ (MetR)	Met repressor, MetJ (MetR)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
J [auth H]	d1mjqh_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Met repressor, MetJ (MetR)	Met repressor, MetJ (MetR)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
K [auth I]	d1mjqi_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Met repressor, MetJ (MetR)	Met repressor, MetJ (MetR)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
L [auth J]	d1mjqj_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Met repressor, MetJ (MetR)	Met repressor, MetJ (MetR)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth A]	SCOP2B Superfamily	Ribbon-helix-helix	8037436	3000295	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	Ribbon-helix-helix	8037436	3000295	SCOP2B (2022-06-29)
G [auth C]	SCOP2B Superfamily	Ribbon-helix-helix	8037436	3000295	SCOP2B (2022-06-29)
H [auth D]	SCOP2B Superfamily	Ribbon-helix-helix	8037436	3000295	SCOP2B (2022-06-29)
I [auth G]	SCOP2B Superfamily	Ribbon-helix-helix	8037436	3000295	SCOP2B (2022-06-29)
J [auth H]	SCOP2B Superfamily	Ribbon-helix-helix	8037436	3000295	SCOP2B (2022-06-29)
K [auth I]	SCOP2B Superfamily	Ribbon-helix-helix	8037436	3000295	SCOP2B (2022-06-29)
L [auth J]	SCOP2B Superfamily	Ribbon-helix-helix	8037436	3000295	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth A]	MetJ	e1mjqA1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: MetJ	ECOD (1.6)
F [auth B]	MetJ	e1mjqB1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: MetJ	ECOD (1.6)
G [auth C]	MetJ	e1mjqC1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: MetJ	ECOD (1.6)
H [auth D]	MetJ	e1mjqD1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: MetJ	ECOD (1.6)
I [auth G]	MetJ	e1mjqG1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: MetJ	ECOD (1.6)
J [auth H]	MetJ	e1mjqH1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: MetJ	ECOD (1.6)
K [auth I]	MetJ	e1mjqI1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: MetJ	ECOD (1.6)
L [auth J]	MetJ	e1mjqJ1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: MetJ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth A]	1.10.140.10	Mainly Alpha	Orthogonal Bundle	MET Apo-Repressor, subunit A	MET Apo-Repressor, subunit A	CATH (4.3.0)
F [auth B]	1.10.140.10	Mainly Alpha	Orthogonal Bundle	MET Apo-Repressor, subunit A	MET Apo-Repressor, subunit A	CATH (4.3.0)
G [auth C]	1.10.140.10	Mainly Alpha	Orthogonal Bundle	MET Apo-Repressor, subunit A	MET Apo-Repressor, subunit A	CATH (4.3.0)
H [auth D]	1.10.140.10	Mainly Alpha	Orthogonal Bundle	MET Apo-Repressor, subunit A	MET Apo-Repressor, subunit A	CATH (4.3.0)
I [auth G]	1.10.140.10	Mainly Alpha	Orthogonal Bundle	MET Apo-Repressor, subunit A	MET Apo-Repressor, subunit A	CATH (4.3.0)
J [auth H]	1.10.140.10	Mainly Alpha	Orthogonal Bundle	MET Apo-Repressor, subunit A	MET Apo-Repressor, subunit A	CATH (4.3.0)
K [auth I]	1.10.140.10	Mainly Alpha	Orthogonal Bundle	MET Apo-Repressor, subunit A	MET Apo-Repressor, subunit A	CATH (4.3.0)
L [auth J]	1.10.140.10	Mainly Alpha	Orthogonal Bundle	MET Apo-Repressor, subunit A	MET Apo-Repressor, subunit A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth A], F [auth B], G [auth C], H [auth D], I [auth G], E [auth A], F [auth B], G [auth C], H [auth D], I [auth G], J [auth H], K [auth I], L [auth J]	PF01340	Met Apo-repressor, MetJ (MetJ)	Met Apo-repressor, MetJ	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E [auth A], F [auth B], G [auth C], H [auth D], I [auth G], E [auth A], F [auth B], G [auth C], H [auth D], I [auth G], J [auth H], K [auth I], L [auth J]	METHIONINE REPRESSOR	DNA binding binding organic cyclic compound binding nucleic acid binding transcription regulator activity DNA-binding transcription factor activity	regulation of cellular process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process oxoacid metabolic process sulfur amino acid metabolic process aspartate family amino acid biosynthetic process organonitrogen compound biosynthetic process aspartate family amino acid metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process small molecule metabolic process sulfur compound metabolic process methionine biosynthetic process organonitrogen compound metabolic process small molecule biosynthetic process carboxylic acid metabolic process L-amino acid biosynthetic process methionine metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process sulfur compound biosynthetic process proteinogenic amino acid biosynthetic process sulfur amino acid biosynthetic process alpha-amino acid biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
A [auth E], B [auth F], C [auth K], D [auth L]	MUTATED MET CONSENSUS OPERATOR DUPLEX	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], F [auth B], G [auth C], H [auth D], I [auth G], E [auth A], F [auth B], G [auth C], H [auth D], I [auth G], J [auth H], K [auth I], L [auth J]	IPR023453	Methionine repressor MetJ domain superfamily	Homologous Superfamily
E [auth A], F [auth B], G [auth C], H [auth D], I [auth G], E [auth A], F [auth B], G [auth C], H [auth D], I [auth G], J [auth H], K [auth I], L [auth J]	IPR010985	Ribbon-helix-helix	Homologous Superfamily
E [auth A], F [auth B], G [auth C], H [auth D], I [auth G], E [auth A], F [auth B], G [auth C], H [auth D], I [auth G], J [auth H], K [auth I], L [auth J]	IPR002084	Methionine repressor MetJ	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.